1. Gene
  2. PDXP - pyridoxal phosphatase Gene

PDXP - pyridoxal phosphatase Gene

中文名称:吡哆醛磷酸酶

种属: Homo sapiens

同用名: CIN; PLP; dJ37E16.5

基因 ID: 57026 | 基因类型: protein coding

关于 PDXP

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:37,658,723-37,666,932 (from NCBI)

This gene has 2 transcripts (splice variants), 194 orthologues and 3 paralogues. Broad expression in brain (RPKM 43.8), small intestine (RPKM 14.2) and 21 other tissues.

功能概要

Pyridoxal 5-prime-phosphate (PLP) 是维生素 B6 的活性形式,可作为维持生化稳态的辅酶。从 PLP 到 4-吡哆酸的优选降解途径涉及 PDXP 对 PLP 的去磷酸化 (Jang 等人,2003 [PubMed 14522954]) 。[OMIM 提供,2008 年 3 月]

Pyridoxal 5-prime-phosphate (PLP) is the active form of vitamin B6 that acts as a coenzyme in maintaining biochemical homeostasis. The preferred degradation route from PLP to 4-pyridoxic acid involves the dephosphorylation of PLP by PDXP (Jang et al., 2003 [PubMed 14522954]).[supplied by OMIM, Mar 2008]

PDXP 基因产物(1)

mRNA Protein Name
NM_020315.5 NP_064711.1 chronophin
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables heat shock protein binding IDA
IDA: 通过直接分析推断
19000834 GOA
enables phosphoprotein phosphatase activity IDA
IDA: 通过直接分析推断
15580268 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17500066 GOA
enables pyridoxal phosphatase activity IDA
IDA: 通过直接分析推断
8132548 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within actin rod assembly IDA
IDA: 通过直接分析推断
19000834 GOA
acts upstream of or within actin rod assembly IMP
IMP: 通过突变表型推断
19000834 GOA
acts upstream of or within cellular response to ATP IDA
IDA: 通过直接分析推断
19000834 GOA
involved in dephosphorylation IDA
IDA: 通过直接分析推断
8132548 GOA
involved in positive regulation of actin filament depolymerization IMP
IMP: 通过突变表型推断
15580268 GOA
involved in protein dephosphorylation IDA
IDA: 通过直接分析推断
15580268 GOA
involved in pyridoxal phosphate catabolic process IDA
IDA: 通过直接分析推断
8132548 GOA
involved in regulation of cytokinesis IMP
IMP: 通过突变表型推断
15580268 GOA
involved in regulation of mitotic nuclear division IMP
IMP: 通过突变表型推断
15580268 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
colocalizes with actin cytoskeleton IDA
IDA: 通过直接分析推断
15580268 GOA
colocalizes with cleavage furrow IDA
IDA: 通过直接分析推断
15580268 GOA
colocalizes with contractile ring IDA
IDA: 通过直接分析推断
15580268 GOA
located in cytosol IDA
IDA: 通过直接分析推断
15580268 GOA
colocalizes with lamellipodium IDA
IDA: 通过直接分析推断
15580268 GOA
colocalizes with midbody IDA
IDA: 通过直接分析推断
15580268 GOA
colocalizes with plasma membrane IDA
IDA: 通过直接分析推断
15580268 GOA
colocalizes with ruffle membrane IDA
IDA: 通过直接分析推断
15580268 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PDXP 蛋白结构

Hydrolase_6

Hydrolase_6: Haloacid dehalogenase-like hydrolase (22 - 127)

Hydrolase_like

Hydrolase_like: HAD-hyrolase-like (211 - 290)

  • 0
  • 100
  • 200
  • 296 a.a.
蛋白主名 其他名称

chronophin

PLP phosphatase

PDXP 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
PDXP Q96GD0 Arrb1 Rattus norvegicus P29066 17500066
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Contractural Arachnodactyly, Congenital

Congenital Contractural Arachnodactyly

Beals Syndrome

CCA

Beals-Hecht Syndrome

Distal Arthrogryposis Type 9

Arthrogryposis, Distal, Type 9

Da9

Arachnodactyly, Contractural Beals Type

Contractures, Multiple With Arachnodactyly

Ear Anomalies-Contractures-Dysplasia Of Bone With Kyphoscoliosis

Arthrogyroposis, Distal, Type 9

Distal Arthrogyropsis Type 9

Cca Syndrome

Arachnodactyly

Laurence-Moon Syndrome

LNMS

Laurence-Moon-Biedl Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus PDXP MGD MGI:1919282
Rattus norvegicus PDXP RGD RGD:1586212
Bos taurus PDXP VGNC VGNC:32722
Canis familiaris PDXP VGNC VGNC:44397
Others PDXP NCBI