Arrb1 - arrestin, beta 1 Gene

种属: Rattus norvegicus

同用名: BARRES

基因 ID: 25387 | 基因类型: protein coding

关于 Arrb1

功能概要

Enables several functions, including AP-2 adaptor complex binding activity; G protein-coupled receptor binding activity; and Arrestin family protein binding activity. Involved in several processes, including regulation of ERK1 and ERK2 cascade; regulation of apoptotic process; and regulation of cellular protein metabolic process. Located in several cellular components, including basolateral plasma membrane; dendritic spine; and postsynaptic density. Used to study congestive heart failure. Biomarker of colitis. Orthologous to human ARRB1 (Arrestin beta 1). [provided by Alliance of Genome Resources, Apr 2022]

Arrb1 基因产物(1)

mRNA	Protein	Name
NM_012910.2	NP_037042.1	beta-arrestin-1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables AP-2 adaptor complex binding	IDA IDA: 通过直接分析推断	15728179	RGD
enables V2 vasopressin receptor binding	IDA IDA: 通过直接分析推断	17513300	RGD
enables alpha-1A adrenergic receptor binding	IPI IPI: 通过物理相互作用推断	18523139	RGD
enables alpha-1B adrenergic receptor binding	IDA IDA: 通过直接分析推断	18523139	RGD
enables arrestin family protein binding	IPI IPI: 通过物理相互作用推断	23886940	RGD
enables clathrin adaptor activity	IDA IDA: 通过直接分析推断	15728179	RGD
enables clathrin binding	IDA IDA: 通过直接分析推断	17513300	RGD
enables enzyme binding	IPI IPI: 通过物理相互作用推断	12399592	RGD
enables follicle-stimulating hormone receptor binding	IPI IPI: 通过物理相互作用推断	16899567	RGD
enables nuclear estrogen receptor binding	IPI IPI: 通过物理相互作用推断	19339617	RGD
enables phosphoprotein binding	IPI IPI: 通过物理相互作用推断	11742073	RGD
enables protein binding	IPI IPI: 通过物理相互作用推断	10725339	RGD
enables protein phosphorylated amino acid binding	IDA IDA: 通过直接分析推断	17513300	RGD
enables signaling receptor binding	IPI IPI: 通过物理相互作用推断	23604254	RGD
enables transmembrane transporter binding	IPI IPI: 通过物理相互作用推断	20650893	RGD

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in G protein-coupled receptor signaling pathway	IDA IDA: 通过直接分析推断	1517224	RGD
involved in endocytosis	IDA IDA: 通过直接分析推断	12519791	RGD
involved in follicle-stimulating hormone signaling pathway	IDA IDA: 通过直接分析推断	16899567	RGD
involved in negative regulation of ERK1 and ERK2 cascade	IMP IMP: 通过突变表型推断	19254952	RGD
involved in negative regulation of GTPase activity	IDA IDA: 通过直接分析推断	1517224	RGD
involved in negative regulation of apoptotic process	IMP IMP: 通过突变表型推断	24378649	RGD
involved in negative regulation of neuron apoptotic process	IMP IMP: 通过突变表型推断	26621121	RGD
involved in negative regulation of protein phosphorylation	IMP IMP: 通过突变表型推断	19254952	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: 通过突变表型推断	19289825	RGD
involved in positive regulation of MAPK cascade	IDA IDA: 通过直接分析推断	12167719	RGD
involved in positive regulation of cell population proliferation	IMP IMP: 通过突变表型推断	25486571	RGD
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: 通过突变表型推断	19171933	RGD
involved in positive regulation of protein phosphorylation	IMP IMP: 通过突变表型推断	24378649	RGD
involved in positive regulation of protein ubiquitination	IMP IMP: 通过突变表型推断	20650893	RGD
involved in positive regulation of smooth muscle cell apoptotic process	IMP IMP: 通过突变表型推断	19171933	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	16325578	RGD
involved in regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	11742073	RGD
involved in regulation of G protein-coupled receptor signaling pathway	IDA IDA: 通过直接分析推断	1517224	RGD
involved in regulation of inositol trisphosphate biosynthetic process	IMP IMP: 通过突变表型推断	20705669	RGD
involved in response to morphine	IEP IEP: 通过表达模式推断	12614678	RGD
involved in response to xenobiotic stimulus	IEP IEP: 通过表达模式推断	21223624	RGD

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in basolateral plasma membrane	IDA IDA: 通过直接分析推断	16899567	RGD
located in dendritic spine	IDA IDA: 通过直接分析推断	1517224	RGD
located in endosome	IDA IDA: 通过直接分析推断	25016018	RGD
is active in glutamatergic synapse	IDA IDA: 通过直接分析推断	1517224	RGD
is active in postsynaptic density	IDA IDA: 通过直接分析推断	1517224	RGD
located in postsynaptic membrane	IDA IDA: 通过直接分析推断	1517224	RGD

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

beta-arrestin-1

Arrb1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属间	Arrb1	P29066	TP53	Homo sapiens	P04637	Pull Down	21857681
种属间	Arrb1	P29066	TP53	Homo sapiens	P04637	Anti Tag CoIP	21857681
种属间	Arrb1	P29066	PDXP	Homo sapiens	Q96GD0	Anti Tag CoIP	17500066
种属间	Arrb1	P29066	F2RL1	Homo sapiens	P55085	GMS	10725339
种属间	Arrb1	P29066	F2RL1	Homo sapiens	P55085	Confocal	10725339
种属间	Arrb1	P29066	F2RL1	Homo sapiens	P55085	Anti Tag CoIP	10725339
种属间	Arrb1	P29066	LIMK1	Homo sapiens	P53667	Pull Down	17500066
种属内	Arrb1	P29066	Raf1	Rattus norvegicus	P11345	GMS	10725339
种属内	Arrb1	P29066	Raf1	Rattus norvegicus	P11345	Anti Tag CoIP	10725339
种属内	Arrb1	P29066	Raf1	Rattus norvegicus	P11345	Confocal	10725339

种属间: 跨种属相互作用 种属内: 同种属相互作用

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS01028	ARRB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Arrb1	NCBI	NCBI:408

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Arrb1 - arrestin, beta 1 Gene

关于 Arrb1

功能概要

Arrb1 基因产物(1)

Arrb1 蛋白互作信息

直系同源

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Arrb1 - arrestin, beta 1 Gene

关于 Arrb1

功能概要

Arrb1 基因产物(1)

Arrb1 蛋白互作信息

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z