ARRB1 - arrestin beta 1 Gene

中文名称：抑制蛋白 1

种属: Homo sapiens

同用名: ARB1; ARR1

基因 ID: 408 | 基因类型: protein coding

关于 ARRB1

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:75,260,122-75,351,661 (from NCBI)

This gene has 12 transcripts (splice variants), 203 orthologues and 3 paralogues. Broad expression in brain (RPKM 24.0), lung (RPKM 19.9) and 24 other tissues.

功能概要

Arrestin/beta-arrestin 蛋白家族的成员被认为参与激动剂介导的 G 蛋白偶联受体脱敏，并导致细胞对激素、神经递质或感觉信号等刺激的反应发生特异性抑制。 Arrestin beta 1 是一种胞质蛋白，在 β-肾上腺素能受体激酶 (BARK) 介导的 β-肾上腺素能受体脱敏中充当辅助因子。除中枢神经系统外，它在外周血白细胞中也有高水平表达，因此 BARK/β-arrestin 系统被认为在调节受体介导的免疫功能中起主要作用。已经描述了编码抑制蛋白 beta 1 的不同亚型的选择性剪接转录本。[RefSeq 提供，2011 年 1 月]

Members of Arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as Hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of Arrestin beta 1 have been described. [provided by RefSeq, Jan 2011]

ARRB1 基因产物(2)

mRNA	Protein	Name
NM_004041.5	NP_004032.2	beta-arrestin-1 isoform A
NM_020251.4	NP_064647.1	beta-arrestin-1 isoform B

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables GTPase activator activity	IMP IMP: 通过突变表型推断	15611106	GOA
enables angiotensin receptor binding	IPI IPI: 通过物理相互作用推断	15611106	GOA
enables arrestin family protein binding	IPI IPI: 通过物理相互作用推断	23886940	GOA
NOT enables histone acetyltransferase activity	IDA IDA: 通过直接分析推断	16325578	GOA
enables insulin-like growth factor receptor binding	IPI IPI: 通过物理相互作用推断	15878855	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA
enables transcription coactivator activity	IMP IMP: 通过突变表型推断	16325578	GOA
enables ubiquitin protein ligase binding	IPI IPI: 通过物理相互作用推断	15878855	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in G protein-coupled receptor internalization	IMP IMP: 通过突变表型推断	10521508	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IDA IDA: 通过直接分析推断	16378096	GOA
involved in negative regulation of Notch signaling pathway	IMP IMP: 通过突变表型推断	23886940	GOA
involved in negative regulation of interleukin-6 production	IDA IDA: 通过直接分析推断	16378096	GOA
involved in negative regulation of interleukin-8 production	IDA IDA: 通过直接分析推断	16378096	GOA
involved in negative regulation of protein ubiquitination	IDA IDA: 通过直接分析推断	16378096	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: 通过直接分析推断	10644702	GOA
involved in positive regulation of Rho protein signal transduction	IMP IMP: 通过突变表型推断	15611106	GOA
involved in positive regulation of protein phosphorylation	IMP IMP: 通过突变表型推断	23633677	GOA
involved in positive regulation of receptor internalization	IMP IMP: 通过突变表型推断	22457824	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	16325578	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: 通过突变表型推断	15878855	GOA
involved in protein ubiquitination	IMP IMP: 通过突变表型推断	15878855	GOA
involved in regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	16325578	GOA
involved in stress fiber assembly	IMP IMP: 通过突变表型推断	15611106	GOA
involved in ubiquitin-dependent protein catabolic process	IMP IMP: 通过突变表型推断	23886940	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in chromatin	IDA IDA: 通过直接分析推断	16325578	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	10823817	GOA
located in cytoplasmic vesicle	IDA IDA: 通过直接分析推断	15611106	GOA
located in nucleus	IDA IDA: 通过直接分析推断	16325578	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ARRB1 蛋白结构

Arrestin_N

Arrestin_C

0
100
200
300
418 a.a.

蛋白主名

其他名称

beta-arrestin-1

arrestin 2

ARRB1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ARRB1	P49407	PPM1B	Homo sapiens	O75688	Anti Tag CoIP	17620599
种属内	ARRB1	P49407	ZRANB2	Homo sapiens	O95218	Anti Bait CoIP	17353931
种属内	ARRB1	P49407	ZRANB2	Homo sapiens	O95218	Anti Tag CoIP	17620599
种属内	ARRB1	P49407	S100A9	Homo sapiens	P06702	Anti Tag CoIP	17620599
种属内	ARRB1	P49407	AP2B1	Homo sapiens	P63010-2	Y2H Prey Pooling	32296183
种属内	ARRB1	P49407	AP2B1	Homo sapiens	P63010-2	Y2H Array	32296183
种属内	ARRB1	P49407	AP2B1	Homo sapiens	P63010-2	Validated Y2H	32296183
种属内	ARRB1	P49407	CD247	Homo sapiens	P20963	Anti Tag CoIP	24502978
种属内	ARRB1	P49407	CD247	Homo sapiens	P20963	IF	24502978
种属内	ARRB1	P49407	CD247	Homo sapiens	P20963	Pull Down	24502978
种属内	ARRB1	P49407	NCL	Homo sapiens	P19338	Anti Tag CoIP	17620599
种属内	ARRB1	P49407	GSN	Homo sapiens	P06396	Anti Tag CoIP	17620599
种属内	ARRB1	P49407	HSPA8	Homo sapiens	P11142	Anti Tag CoIP	17620599
种属内	ARRB1	P49407	PKM	Homo sapiens	P14618	Anti Tag CoIP	17620599
种属内	ARRB1	P49407	YWHAQ	Homo sapiens	P27348	Anti Tag CoIP	17620599
种属内	ARRB1	P49407	TP53	Homo sapiens	P04637	Anti Bait CoIP	21857681
种属内	ARRB1	P49407	MDM2	Homo sapiens	Q00987	Anti Bait CoIP	21857681
种属内	ARRB1	P49407	GNAQ	Homo sapiens	P50148	Anti Tag CoIP	23353685
种属内	ARRB1	P49407	PRP4K	Homo sapiens	Q13523	Anti Tag CoIP	17620599
种属内	ARRB1	P49407	TCOF1	Homo sapiens	Q13428	Anti Bait CoIP	17353931
种属内	ARRB1	P49407	TCOF1	Homo sapiens	Q13428	Anti Tag CoIP	17620599
种属内	ARRB1	P49407	NOLC1	Homo sapiens	Q14978	Anti Tag CoIP	33961781
种属内	ARRB1	P49407	NOLC1	Homo sapiens	Q14978	Anti Tag CoIP	17620599
种属内	ARRB1	P49407	NOLC1	Homo sapiens	Q14978	Anti Bait CoIP	17353931
种属内	ARRB1	P49407	GNAS	Homo sapiens	Q5JWF2	Anti Bait CoIP	23353685
种属内	ARRB1	P49407	GNAS	Homo sapiens	Q5JWF2	Anti Tag CoIP	23353685
种属内	ARRB1	P49407	STK38	Homo sapiens	Q15208	Anti Tag CoIP	17620599
种属内	ARRB1	P49407	MAP3K5	Homo sapiens	Q99683	Peptide Array	19782076
种属内	ARRB1	P49407	SRC	Homo sapiens	P12931	Anti Bait CoIP	19202075
种属内	ARRB1	P49407	SRC	Homo sapiens	P12931	Anti Bait CoIP	16432186
种属内	ARRB1	P49407	EDNRA	Homo sapiens	P25101	Anti Bait CoIP	19202075
种属内	ARRB1	P49407	AXIN1	Homo sapiens	O15169	Anti Bait CoIP	19202075
种属内	ARRB1	P49407	MAPK9	Homo sapiens	P45984	Y2H Array	21988832
种属内	ARRB1	P49407	MAPK9	Homo sapiens	P45984	Y2H	21988832
种属内	ARRB1	P49407	MAPK9	Homo sapiens	P45984	Y2H Array	31515488
种属内	ARRB1	P49407	MAPK9	Homo sapiens	P45984	Y2H Array	25416956
种属内	ARRB1	P49407	ZBTB43	Homo sapiens	O43298	Y2H Pooling	16189514
种属内	ARRB1	P49407	ZBTB43	Homo sapiens	O43298	Y2H Array	31515488
种属内	ARRB1	P49407	ZBTB43	Homo sapiens	O43298	Y2H Prey Pooling	32296183
种属内	ARRB1	P49407	ZBTB43	Homo sapiens	O43298	Y2H Array	32296183
种属内	ARRB1	P49407	GNMT	Homo sapiens	Q14749	Validated Y2H	32296183
种属内	ARRB1	P49407	GNMT	Homo sapiens	Q14749	Confocal	21988832
种属内	ARRB1	P49407	GNMT	Homo sapiens	Q14749	Y2H Array	32296183
种属内	ARRB1	P49407	GNMT	Homo sapiens	Q14749	Y2H Pooling	16189514
种属内	ARRB1	P49407	GNMT	Homo sapiens	Q14749	Y2H Array	31515488
种属内	ARRB1	P49407	GNMT	Homo sapiens	Q14749	Y2H Prey Pooling	32296183
种属内	ARRB1	P49407	YY1	Homo sapiens	P25490	Y2H	19879840
种属内	ARRB1	P49407	YY1	Homo sapiens	P25490	Anti Bait CoIP	19879840
种属内	ARRB1	P49407	YY1	Homo sapiens	P25490	Anti Tag CoIP	19879840
种属内	ARRB1	P49407	PPM1A	Homo sapiens	P35813	Anti Tag CoIP	17620599

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 ARRB1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7606	ARRB1/Beta-Arrestin 1 Protein, Human (His)	P49407 (M1-R418)	≥95%

ARRB1 抗体

目录号	产品名	应用	反应物种
HY-P80569	beta Arrestin 1 Antibody (YA822)	WB	Human

关联疾病

疾病名称

别名

Placenta Praevia

Placenta Previa	Haemorrhage From Placenta Previa
Placenta Previa Haemorrhage	Lateral Placenta
Low Implantation Of Placenta Nos Or With Haemorrhage	Total Placenta Previa
Total Placenta Praevia Nos Or With Haemorrhage	Placental Previa Haemorrhage
Pp - [Placenta Previa]	Placenta Previa Marginalis
Placenta Previa Partialis	Partial Placenta Previa
Placenta Previa Centralis	Low Implantation Of Placenta
Low Implantation Or Insertion Of Placenta	Low Insertion Of Placenta
Low Lying Placenta	Marginal Placenta
Marginal Placenta Praevia Nos Or With Haemorrhage	Marginal Placenta Previa
Marginal Placental Haemorrhage	Partial Placenta Praevia Nos Or With Haemorrhage

Nephrogenic Syndrome Of Inappropriate Antidiuresis

NSIAD

Precocious Puberty, Central, 1

CPPB1	Central Precocious Puberty 1
Precocious Puberty, Central 1	Puberty, Precocious, Central, Type 1

Whim Syndrome 1

Whim Syndrome	Whims
Warts, Hypogammaglobulinemia, Infections, And Myelokathexis	WHIMS1
Warts-Hypogammaglobulinemia-Infections-Myelokathexis Syndrome	Warts, Hypogammaglobulinemia, Infections, And Myelokathexis Syndrome 1
Myelokathexis, Isolated	Wilm
Warts-Infections-Leukopenia-Myelokatexis Syndrome	Warts, Hypogammaglobulinemia, Infections And Myelokathexis Syndrome 1

Placental Abruption

Abruptio Placentae	Abruptio Placenta
Abortion, Threatened	Threatened Miscarriage
Haemorrhage Specified As Due To Threatened Abortion	Spontaneous Threatened Abortion

Multiple Sclerosis

MS	Multiple Sclerosis, Susceptibility To
Disseminated Sclerosis	Multiple Sclerosis, Disease Progression, Modifier Of
Insular Sclerosis	Multiple Sclerosis Modifier Of Disease Progression
Multiple Sclerosis, Susceptibility To 1	Multiple Sclerosis, Susceptibility To, 1
Multiple Sclerosis 1	Generalized Multiple Sclerosis
Multiple Sclerosis Variant	Multiple Sclerosis Susceptibility To
Cerebrospinal Sclerosis	Generalised Multiple Sclerosis
Ms - [Multiple Sclerosis]	Disseminated Cerebrospinal Sclerosis
Disseminated Multiple Sclerosis	Disseminated Nervous System Myelosclerosis
Multiple Cerebrospinal Sclerosis	Multiple Combined Sclerosis
Multiple Sclerosis Generalised	Disseminated Brain Sclerosis
Disseminated Spinal Sclerosis	Insular Brain Sclerosis
Miliary Brain Sclerosis	Multiple Combined Sclerosis Of Spinal Cord
Multiple Ascending Sclerosis	Multiple Brain Sclerosis
Multiple Sclerosis Of Brain Stem	Multiple Sclerosis Of The Brain Stem
Multiple Sclerosis Of Cord	Sclérose En Plaques
Plaque Sclerosis	Multiple Sclerosis Of The Spinal Cord

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Malignant Secondary Hypertension

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS01028	ARRB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	ARRB1	MGD	MGI:99473
Bos taurus	ARRB1	VGNC	VGNC:26169
Macaca mulatta	ARRB1	VGNC	VGNC:70021
Felis catus	ARRB1	VGNC	VGNC:68263
Rattus norvegicus	ARRB1	RGD	RGD:2156
Canis familiaris	ARRB1	VGNC	VGNC:38136
Others	ARRB1	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4