CD177 - CD177 molecule Gene

中文名称：CD177 分子

种属: Homo sapiens

同用名: NB1; PRV1; HNA2A; PRV-1; HNA-2a; NB1 GP

基因 ID: 57126 | 基因类型: protein coding

关于 CD177

Cytogenetic location: 19q13.31 Genomic coordinates (GRCh38): 19:43,353,686-43,366,081 (from NCBI)

This gene has 3 transcripts (splice variants), 97 orthologues and 2 paralogues. Biased expression in bone marrow (RPKM 83.5), colon (RPKM 72.9) and 1 other tissue.

功能概要

该基因编码糖基磷脂酰肌醇 (GPI) 连接的细胞表面糖蛋白，在中性粒细胞活化中发挥作用。该蛋白可结合血小板内皮细胞粘附分子-1，并在中性粒细胞迁移中发挥作用。该基因的突变与骨髓增生性疾病有关。已在患有真性红细胞增多症的患者中发现该基因的过度表达。针对该蛋白的自身抗体可能导致肺输血反应，它可能与韦格纳肉芽肿病有关。已鉴定出与 19 号染色体上该基因相邻的相关假基因。[RefSeq 提供，2014 年 4 月]

This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified. [provided by RefSeq, Apr 2014]

CD177 基因产物(1)

mRNA	Protein	Name
NM_020406.4	NP_065139.2	CD177 antigen precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables calcium-dependent protein binding	IPI IPI: 通过物理相互作用推断	17580308	GOA
enables integrin binding	IPI IPI: 通过物理相互作用推断	21193407	GOA
enables protease binding	IPI IPI: 通过物理相互作用推断	17244676	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cell adhesion	IMP IMP: 通过突变表型推断	28807980	GOA
involved in cell-cell adhesion via plasma-membrane adhesion molecules	IMP IMP: 通过突变表型推断	17580308	GOA
involved in cell-cell junction maintenance	IMP IMP: 通过突变表型推断	23202369	GOA
involved in leukocyte cell-cell adhesion	IMP IMP: 通过突变表型推断	17580308	GOA
involved in neutrophil extravasation	IMP IMP: 通过突变表型推断	17580308	GOA
NOT involved in neutrophil migration	IMP IMP: 通过突变表型推断	28240246	GOA
involved in neutrophil migration	IMP IMP: 通过突变表型推断	28807980	GOA
involved in positive regulation of neutrophil degranulation	IGI IGI: 通过遗传相互作用推断	21193407	GOA
involved in positive regulation of superoxide anion generation	IGI IGI: 通过遗传相互作用推断	21193407	GOA
involved in protein localization to cell surface	IMP IMP: 通过突变表型推断	17244676	GOA
involved in regulation of endocytosis	IDA IDA: 通过直接分析推断	28807980	GOA
involved in regulation of integrin-mediated signaling pathway	IMP IMP: 通过突变表型推断	28807980	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in plasma membrane	IDA IDA: 通过直接分析推断	12675722	GOA
located in plasma membrane raft	IDA IDA: 通过直接分析推断	21193407	GOA
located in secretory granule membrane	IDA IDA: 通过直接分析推断	18462208	GOA
located in tertiary granule membrane	IDA IDA: 通过直接分析推断	18462208	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

CD177 antigen

NB1 glycoprotein

CD177 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CD177	Q8N6Q3	KCNIP3	Homo sapiens	Q9Y2W7	Validated Y2H	32296183
种属内	CD177	Q8N6Q3	KCNIP3	Homo sapiens	Q9Y2W7	Y2H Prey Pooling	32296183
种属内	CD177	Q8N6Q3	KCNIP3	Homo sapiens	Q9Y2W7	Y2H Array	25416956
种属内	CD177	Q8N6Q3	KCNIP3	Homo sapiens	Q9Y2W7	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CD177 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7801	CD177 Protein, Human (HEK293, His)	AAH29167.1 (L22-G407)	≥95%

关联疾病

疾病名称

别名

Polycythemia

Erythrocythemia	Polycythemia Vera
Polycythaemia Due To High Altitude

Polycythemia Vera

PV	Polycythemia Rubra Vera
Prv	Osler-Vaquez Disease
Chronic Erythremia	Polycythaemia Rubra Vera
Primary Polycythemia	Vaquez Disease
Polycythemia Vera, Somatic	Osler-Vaquez Syndrome
Proliferative Polycythaemia	Polycythemia Ruba Vera
Acquired Primary Erythrocytosis	Heilmeyer-Schoner Disease
Vaquez Osler Disease	Primary Polycythaemia

Essential Thrombocythemia

Essential Thrombocytosis	Familial Thrombocytosis
Hemorrhagic Thrombocythemia	Hereditary Thrombocythemia
Primary Thrombocytosis	Idiopathic Thrombocythemia
Primary Thrombocythemia	Thrombocythemia, Essential
Essential Thrombocythaemia	Et
Familial Thrombocythemia	Thrombocythemia Essential

Myelofibrosis

Primary Myelofibrosis	Agnogenic Myeloid Metaplasia
Idiopathic Myelofibrosis	Myeloid Metaplasia
Myelofibrosis With Myeloid Metaplasia	Osteomyelofibrosis
Megakaryocytic Myelosclerosis	Myelosclerosis
Chronic Idiopathic Myelofibrosis	Myelofibrosis, Idiopathic
Myelofibrosis With Myeloid Metaplasia, Somatic	Myelofibrosis, Somatic
Aleukemic Myelosis	Bone Marrow Fibrosis
MYELOF	MMM
Agnogenic Myeloid Metaplasia With Myelofibrosis	Ammm
Myelosclerosis With Myeloid Metaplasia	Myelofibrosis Nos

Deep Leiomyoma

Myeloproliferative Neoplasm

Myeloproliferative Disorder	Chronic Myeloproliferative Disease
Myeloproliferative Neoplasms	Chronic Myeloproliferative Disorder
Cmpd	Cmpd, U
Chronic Myeloproliferative Disorders	Mpd
Mpn	Myeloproliferative Disorders
Myeloproliferative Disease	Campomelic Dysplasia

Neutropenia

Leukopenia

Thrombocytosis

Thrombocythaemia

Myopathy, Centronuclear, 1

Autosomal Dominant Centronuclear Myopathy	CNM1
Centronuclear Myopathy 1	Ad-Cnm
Myopathy, Centronuclear, Autosomal Dominant	Myotubular Myopathy, Autosomal Dominant
Centronuclear Myopathy, Autosomal, Modifier Of	Autosomal Dominant Myotubular Myopathy
Dnm2-Related Centronuclear Myopathy	Centronuclear Myopathy Autosomal Dominant
Myopathies, Structural, Congenital	Myopathy, Centronuclear, Type 1

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia	Chronic Myelogenous Leukemia
CML	Chronic Granulocytic Leukemia
Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib	Chronic Myeloid Leukaemia
Chronic Granulocytic Leukaemia	Chronic Myelogenous Leukaemia
Myeloid Leukemia, Chronic	Leukemia, Chronic Myelogenous
Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic	Cml - Chronic Myelogenous Leukemia
Cgl	Chronic Myelocytic Leukemia
Leukemia, Chronic Myeloid, Atypical	ACML
Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative	Myeloid Leukemia Chronic
Leukemia, Myeloid, Chronic	Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative
Cml- [Chronic Myeloid Leukaemia]	Cgl - [Chronic Granulocytic Leukaemia]
Chronic Myelocytic Leukaemia

Adult Hepatocellular Carcinoma

Adult Primary Hepatocellular Carcinoma	Adult Hepatoma
Adult Hcc

Myelodysplastic Syndrome

Myelodysplastic Syndromes	Myelodysplasia
MDS	Myelodysplastic Syndrome Included
Myelodysplastic Syndrome, Susceptibility To, Included	Myelodysplastic Syndrome, Somatic
Myelodysplastic Syndrome, Susceptibility To

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02196	CD177 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	CD177	RGD	RGD:1562941
Macaca mulatta	CD177	VGNC	VGNC:70912
Mus musculus	CD177	MGD	MGI:1916141
Canis familiaris	CD177	VGNC	VGNC:38934
Bos taurus	CD177	VGNC	VGNC:27006
Others	CD177	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CD177 - CD177 molecule Gene

关于 CD177

功能概要

CD177 基因产物(1)

CD177 蛋白互作信息

重组 CD177 蛋白

关联疾病

直系同源

热门区域

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CD177 - CD177 molecule Gene

关于 CD177

功能概要

CD177 基因产物(1)

CD177 蛋白互作信息

重组 CD177 蛋白

关联疾病

相关产品

直系同源

热门区域

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C

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J

L

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