2. Gene
  3. SENP7 - SUMO specific peptidase 7 Gene

SENP7 - SUMO specific peptidase 7 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：SUMO 特异性肽酶 7

种属: Homo sapiens

基因 ID: 57337 | 基因类型: protein coding

关于 SENP7

Cytogenetic location: 3q12.3 Genomic coordinates (GRCh38): 3:101,324,205-101,513,212 (from NCBI)

This gene has 8 transcripts (splice variants), 267 orthologues and 1 paralogue. Ubiquitous expression in endometrium (RPKM 9.0), lymph node (RPKM 7.6) and 25 other tissues.

功能概要

许多细胞过程都需要通过添加小泛素样 SUMO 蛋白 (参见 SUMO1；MIM 601912) 对蛋白质进行可逆的翻译后修饰。 SUMO 特异性蛋白酶，如 SENP7，处理 SUMO 前体以产生缀合反应所需的 C 末端二甘氨酸基序。它们还显示用于 SUMO 结合底物解结合的异肽酶活性 (Lima 和 Reverter，2008 [PubMed 18799455]) 。[OMIM 提供，2009 年 6 月]

The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for many cellular processes. SUMO-specific proteases, such as SENP7, process SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009]

SENP7 基因产物(6)

mRNA Protein Name
NM_001077203.3 NP_001070671.1 sentrin-specific protease 7 isoform 2
NM_001282801.2 NP_001269730.1 sentrin-specific protease 7 isoform 3
NM_001282802.2 NP_001269731.1 sentrin-specific protease 7 isoform 4
NM_001282803.2 NP_001269732.1 sentrin-specific protease 7 isoform 5
NM_001282804.2 NP_001269733.1 sentrin-specific protease 7 isoform 6
NM_020654.5 NP_065705.3 sentrin-specific protease 7 isoform 1

SENP7 蛋白结构

Peptidase_C48

Peptidase_C48: Ulp1 protease family, C-terminal catalytic domain (774 - 1015)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1050 a.a.
蛋白主名 其他名称

sentrin-specific protease 7

SUMO-1-specific protease 2

重组 SENP7 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71289 SENP7 Protein, Human Q9BQF6-1 (M695-A864) ≥95%

关联疾病

疾病名称 别名
Malaria

Malaria, Susceptibility To

Malaria, Resistance To

Malaria, Cerebral

Cerebral Malaria

Malaria, Severe, Susceptibility To

Malaria, Severe, Resistance To

Malaria, Cerebral, Susceptibility To

Induced Malaria

Malaria, Vivax, Protection Against

Malaria, Severe

Malaria, Cerebral, Reduced Risk Of

Malaria, Protection Against

Resistance To Malaria Due To G6pd Deficiency

Malaria Due To G6pd Deficiency

Malarial Encephalitis

CM

Malaria Cerebral

Susceptibility To Malaria

Acute Pernicious Fever

Aestivo-Autumnal Fever

Aestivo Autumnal Malaria

Chagres Fever

Continued Malaria Fever

Estivo-Autumnal Fever

Estivo-Autumnal Malaria

Estivo-Autumnal Malarial Fever

Falciparum Fever

Malignant Tertian Fever

Malignant Tertian Malaria

Pernicious Intermittent Fever

Pernicious Malaria

Quotidian Malaria

Subtertian Fever

Subtertian Malaria Fever

Subtertian Malignant Tertian Malaria

Tropical Malaria

Algid Malaria

Bilious Haemoglobinuric Fever

Black Water Fever

Blackwater Fever

Malarial Blackwater Fever

Severe Malarial Falciparum

West African Fever

Malarial Haematinuria

Haemoglobinuric Fever

Haemoglobinuric Malaria

Severe Plasmodium Falciparum Malaria

Malarial Haemoglobinuria

Malarial Haematuria

Falciparum Malaria [Malignant Tertian]

Malaria Tropica

Malarial Shock

Chagres Virus Disease

Malignant Malaria

Mtm - [Malignant Tertian Malaria]

Tm -[Malignant Tertian Malaria]

Panama Fever

St - [Subtertian Malaria]

Malarial Quotidian

Benign Tertian Malaria

Tertian Ague

Vivax Fever

Plasmodium Vivax Malaria Nos

Btm - [Benign Tertian Malaria]

Bt - [Benign Tertian Malaria]

Vivax Malaria

Benign Tertian Vivax Malaria

Tertian Malaria

Quartan Malaria

Quartan Ague

Quartan Fever

Plasmodium Malariae Malaria Nos

Quartan Malarial

Malaria By Plasmodium Malariae

Malariae Malaria

Ovale Tertian Malaria

Plasmodium Ovale Fever

Malaria Fever By Plasmodium Ovale

Ovale Malaria

Malaria By Plasmodium Ovale

Malarial Ovale

Marsh Fever

Remittent Congestive Fever

Coastal Fever

Remittent Gastric Fever

Miasmatic Fever

Congestive Remittent Fever

Intermittent Fever

Jungle Fever

Paludism

Cameroon Fever

Ague

Corsican Fever

Intermittent Bilious Fever

Disease Due To Plasmodiidae

Malarial Fever

Plasmodiosis

Remittent Fever

Roman Fever

Malaria Fever Nos

Malaria Nos

Paludal Fever

Clinically Diagnosed Malaria

Clinically Diagnosed Malaria Without Parasitological Confirmation

Congestive Fever

Malarial Cachexia

Marsh Cachexia

Paludal Cachexia

Recurrent Malaria

Remittent Malaria
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12676 SENP7 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus SENP7 VGNC VGNC:52825
Canis familiaris SENP7 VGNC VGNC:53087
Macaca mulatta SENP7 VGNC VGNC:77346
Felis catus SENP7 VGNC VGNC:65005
Rattus norvegicus SENP7 RGD RGD:1305510
Mus musculus SENP7 MGD MGI:1913565
Others SENP7 NCBI
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