1. Gene
  2. MICAL3 - microtubule associated monooxygenase, calponin and LIM domain containing 3 Gene

MICAL3 - microtubule associated monooxygenase, calponin and LIM domain containing 3 Gene

中文名称:含微管相关的单加氧酶、钙调蛋白和 LIM 结构域 3

种属: Homo sapiens

同用名: MICAL-3

基因 ID: 57553 | 基因类型: protein coding

关于 MICAL3

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:17,787,649-18,024,561 (from NCBI)

This gene has 20 transcripts (splice variants), 210 orthologues and 36 paralogues. Ubiquitous expression in testis (RPKM 5.1), brain (RPKM 4.5) and 25 other tissues.

功能概要

启用肌动蛋白结合活动。参与肌动蛋白丝解聚。位于多个细胞成分中,包括 Flemming 体;细胞间桥;和核质。 [由基因组资源联盟提供,2022 年 4 月]

Enables actin binding activity. Involved in actin filament depolymerization. Located in several cellular components, including Flemming body; intercellular bridge; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

MICAL3 基因产物(3)

mRNA Protein Name
NM_001122731.2 NP_001116203.1 [F-actin]-monooxygenase MICAL3 isoform 3
NM_001136004.3 NP_001129476.1 [F-actin]-monooxygenase MICAL3 isoform 2
NM_015241.3 NP_056056.2 [F-actin]-monooxygenase MICAL3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables actin binding IDA
IDA: 通过直接分析推断
24440334 GOA
enables molecular adaptor activity EXP
EXP: 通过实验结果推断
27528609 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
27528609 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in actin filament depolymerization IDA
IDA: 通过直接分析推断
24440334 GOA
involved in cytoskeleton organization IDA
IDA: 通过直接分析推断
24440334 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
24440334 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

MICAL3 蛋白结构

FAD_binding_3

FAD_binding_3: FAD binding domain (87 - 124)

CH

CH: Calponin homology (CH) domain (523 - 623)

LIM

LIM: LIM domain (764 - 820)

DUF3585

DUF3585: Protein of unknown function (DUF3585) (1849 - 1989)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2002 a.a.
蛋白主名 其他名称

[F-actin]-monooxygenase MICAL3

[F-actin]-methionine sulfoxide oxidase MICAL3

直系同源

种属 基因名 来源 基因 ID
Mus musculus MICAL3 MGD MGI:2442733
Macaca mulatta MICAL3 VGNC VGNC:107800
Rattus norvegicus MICAL3 RGD RGD:1359504
Canis familiaris MICAL3 VGNC VGNC:43219
Bos taurus MICAL3 VGNC VGNC:31459