2. Gene
  3. STIM2 - stromal interaction molecule 2 Gene

STIM2 - stromal interaction molecule 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：基质相互作用分子 2

种属: Homo sapiens

基因 ID: 57620 | 基因类型: protein coding

关于 STIM2

Cytogenetic location: 4p15.2 Genomic coordinates (GRCh38): 4:26,860,841-27,025,381 (from NCBI)

This gene has 11 transcripts (splice variants), 271 orthologues and 1 paralogue. Ubiquitous expression in gall bladder (RPKM 9.8), lymph node (RPKM 8.6) and 25 other tissues.

功能概要

该基因是基质相互作用分子 (STIM) 家族的成员，可能与相关的家族成员 STIM1 一起起源于一个共同的祖先基因。编码的蛋白质的功能是调节细胞质和内质网中的钙浓度，并参与质膜 Orai CA (2+) 进入通道的激活。该基因从非 AUG (UUG) 起始位点开始翻译。信号肽从产生的蛋白质上切下。多个转录本变体由可变剪接产生。[RefSeq 提供，2009 年 12 月]

This gene is a member of the stromal interaction molecule (STIM) family and likely arose, along with related family member STIM1, from a common ancestral gene. The encoded protein functions to regulate calcium concentrations in the cytosol and endoplasmic reticulum, and is involved in the activation of plasma membrane Orai CA(2+) entry channels. This gene initiates translation from a non-AUG (UUG) start site. A signal peptide is cleaved from the resulting protein. Multiple transcript variants result from alternative splicing. [provided by RefSeq, Dec 2009]

STIM2 基因产物(3)

mRNA Protein Name
NM_001169117.2 NP_001162588.1 stromal interaction molecule 2 isoform 3 precursor
NM_001169118.2 NP_001162589.1 stromal interaction molecule 2 isoform 1 precursor
NM_020860.4 NP_065911.3 stromal interaction molecule 2 isoform 2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium channel regulator activity IMP
IMP: 通过突变表型推断
18160041 GOA
enables calcium ion binding IDA
IDA: 通过直接分析推断
18166150 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11463338 GOA
enables store-operated calcium channel activity IDA
IDA: 通过直接分析推断
16860747 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in activation of store-operated calcium channel activity IDA
IDA: 通过直接分析推断
17905723 GOA
involved in activation of store-operated calcium channel activity IMP
IMP: 通过突变表型推断
18160041 GOA
involved in intracellular calcium ion homeostasis IMP
IMP: 通过突变表型推断
18160041 GOA
involved in positive regulation of calcium ion transport IDA
IDA: 通过直接分析推断
17905723 GOA
involved in positive regulation of calcium ion transport IMP
IMP: 通过突变表型推断
18160041 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
18160041 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
18160041 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

STIM2 蛋白结构

SAM_2

SAM_2: SAM domain (Sterile alpha motif) (133 - 201)

  • 0
  • 200
  • 400
  • 600
  • 746 a.a.
蛋白主名 其他名称

stromal interaction molecule 2

STIM2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
STIM2 Q9P246 STIM1 Homo sapiens Q13586
Anti Tag CoIP
33961781
种属内
STIM2 Q9P246 STIM1 Homo sapiens Q13586
Anti Tag CoIP
28514442
种属内
STIM2 Q9P246 STIM1 Homo sapiens Q13586
Anti Bait CoIP
11463338
种属内
STIM2 Q9P246 STIM1 Homo sapiens Q13586
Anti Tag CoIP
35271311
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Immunodeficiency 10

Immune Dysfunction With T-Cell Inactivation Due To Calcium Entry Defect 2

Combined Immunodeficiency Due To Stim1 Deficiency

IMD10

Stim1 Deficiency

Cid Due To Stim1 Deficiency

Immune Dysfunction, With T-Cell Inactivation Due To Calcium Entry Defect 2

Immunodeficiency, Type 10
T Cell And Nk Cell Immunodeficiency
Stormorken Syndrome

Thrombocytopathy, Asplenia, And Miosis

Stormorken-Sjaastad-Langslet Syndrome

STRMK

York Platelet Syndrome

Yps

Thrombocytopathy, Asplenia And Miosis

Thrombocytopathy Asplenia Miosis

Thrombocytopathy-Asplenia-Miosis Syndrome

Miosis Disorder
Amelogenesis Imperfecta, Type Iiia

Ai3

Adhcai

Amelogenesis Imperfecta Type 3

AI3A

Amelogenesis Imperfecta, Type Iii

Amelogenesis Imperfecta, Hypocalcification Type, Autosomal Dominant

Amelogenesis Imperfecta Type 3a

Amelogenesis Imperfecta Hypomineralization Type

Amelogenesis Imperfecta Type Iii

Hypocalcified Amelogenesis Imperfecta

Amelogenesis Imperfecta, Type 3

Amelogenesis Imperfecta, Hypomineralization Type

Autosomal Dominant Amelogenesis Imperfecta Hypocalcification Type

Amelogenesis Imperfecta 3a

Amelogenesis Imperfecta Hypocalcification Type Autosomal Dominant
Myopathy, Tubular Aggregate, 1

Tubular Aggregate Myopathy

Tam

Myopathy With Tubular Aggregates

TAM1

Myopathy, Tubular Aggregate

Tubular Aggregate Myopathy 1
Anhidrosis

Hypohidrosis

Absence Of Sweating

Adiaphoresis

Impaired Sweating

Oligohidrosis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13914 STIM2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus STIM2 RGD RGD:1304641
Bos taurus STIM2 VGNC VGNC:53776
Macaca mulatta STIM2 VGNC VGNC:77965
Canis familiaris STIM2 VGNC VGNC:46902
Felis catus STIM2 VGNC VGNC:65773
Mus musculus STIM2 MGD MGI:2151156
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