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  2. EP400 - E1A binding protein p400 Gene

EP400 - E1A binding protein p400 Gene

中文名称:E1A 结合蛋白 p400

种属: Homo sapiens

同用名: P400; CAGH32; TNRC12

基因 ID: 57634 | 基因类型: protein coding

关于 EP400

Cytogenetic location: 12q24.33 Genomic coordinates (GRCh38): 12:131,949,942-132,080,460 (from NCBI)

This gene has 9 transcripts (splice variants), 229 orthologues and 30 paralogues. Ubiquitous expression in testis (RPKM 8.1), ovary (RPKM 5.8) and 25 other tissues.

功能概要

预计将启用多种功能,包括 ATP 绑定活动; ATP 依赖性染色质重塑活性;和蛋白抗原结合活性。参与组蛋白 H2A 乙酰化和组蛋白 H4 乙酰化。 NuA4 组蛋白乙酰转移酶复合物和 Swr1 复合物的一部分。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable several functions, including ATP binding activity; ATP-dependent chromatin remodeler activity; and protein antigen binding activity. Involved in histone H2A acetylation and histone H4 acetylation. Part of NuA4 Histone Acetyltransferase complex and Swr1 complex. [provided by Alliance of Genome Resources, Apr 2022]

EP400 基因产物(1)

mRNA Protein Name
NM_015409.5 NP_056224.3 E1A-binding protein p400
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16601686 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of double-strand break repair via homologous recombination IDA
IDA: 通过直接分析推断
27153538 GOA
involved in regulation of cell cycle IMP
IMP: 通过突变表型推断
27153538 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of NuA4 histone acetyltransferase complex IDA
IDA: 通过直接分析推断
14966270 GOA
part of Swr1 complex IDA
IDA: 通过直接分析推断
24463511 GOA
part of nucleosome IDA
IDA: 通过直接分析推断
27153538 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

EP400 蛋白结构

HSA

HSA: HSA (764 - 835)

SNF2_N

SNF2_N: SNF2 family N-terminal domain (1058 - 1338)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (1897 - 1963)

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  • 3123 a.a.
蛋白主名 其他名称

E1A-binding protein p400

CAG repeat protein 32

关联疾病

疾病名称 别名
Ossifying Fibromyxoid Tumor

Ossifying Fibromyxoid Tumour

Ossifying Fibromyxoma

Endometrial Stromal Sarcoma

Ess

Endometrial Stromal Sarcoma, High Grade

Undifferentiated Endometrial Sarcoma

Stromal Sarcoma Of The Corpus Uteri

Sarcoma Endometrial Stromal

Sarcoma, Endometrial Stromal

Undifferentiated Stromal Sarcoma

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta EP400 VGNC VGNC:97765
Mus musculus EP400 MGD MGI:1276124
Canis familiaris EP400 VGNC VGNC:40390
Bos taurus EP400 VGNC VGNC:28517
Rattus norvegicus EP400 RGD RGD:1304733