1. Gene
  2. PTN - pleiotrophin Gene

PTN - pleiotrophin Gene

中文名称:多效蛋白

种属: Homo sapiens

同用名: HARP; HBBM; HBNF; HBGF8; NEGF1; OSF-1; HB-GAM; HBGF-8; HBNF-1

基因 ID: 5764 | 基因类型: protein coding

关于 PTN

Cytogenetic location: 7q33 Genomic coordinates (GRCh38): 7:137,227,341-137,343,733 (from NCBI)

This gene has 3 transcripts (splice variants), 208 orthologues and 1 paralogue. Broad expression in brain (RPKM 83.5), prostate (RPKM 56.7) and 17 other tissues.

功能概要

该基因编码的蛋白质是一种分泌型肝素结合生长因子。该蛋白在细胞生长和存活、细胞迁移、血管生成和肿瘤发生中具有重要作用。可变剪接和替代启动子的使用会导致多种转录本变体。[RefSeq 提供,2016 年 10 月]

The protein encoded by this gene is a secreted heparin-binding growth factor. The protein has significant roles in cell growth and survival, cell migration, angiogenesis and tumorigenesis. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]

PTN 基因产物(3)

mRNA Protein Name
NM_001321386.2 NP_001308315.1 pleiotrophin isoform 1 precursor
NM_001321387.3 NP_001308316.1 pleiotrophin isoform 2 precursor
NM_002825.7 NP_002816.1 pleiotrophin isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables carbohydrate binding EXP
EXP: 通过实验结果推断
26896299 GOA
enables chondroitin sulfate binding IDA
IDA: 通过直接分析推断
26896299 GOA
enables growth factor activity IDA
IDA: 通过直接分析推断
1733956 GOA
enables heparin binding IDA
IDA: 通过直接分析推断
1733956 GOA
enables integrin binding IPI
IPI: 通过物理相互作用推断
19141530 GOA
enables molecular function activator activity IPI
IPI: 通过物理相互作用推断
21344482 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10706604 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
20873783 GOA
enables protein phosphatase inhibitor activity IDA
IDA: 通过直接分析推断
27445335 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in integrin-mediated signaling pathway IDA
IDA: 通过直接分析推断
19141530 GOA
involved in ossification involved in bone remodeling IDA
IDA: 通过直接分析推断
19442624 GOA
involved in positive regulation of cell population proliferation IDA
IDA: 通过直接分析推断
1733956 GOA
involved in positive regulation of oligodendrocyte differentiation IDA
IDA: 通过直接分析推断
27445335 GOA
involved in positive regulation of oligodendrocyte differentiation IMP
IMP: 通过突变表型推断
30667096 GOA
involved in receptor clustering IDA
IDA: 通过直接分析推断
27445335 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
1733956 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
20873783 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PTN 蛋白结构

PTN_MK_N

PTN_MK_N: PTN/MK heparin-binding protein family, N-terminal domain (34 - 95)

PTN_MK_C

PTN_MK_C: PTN/MK heparin-binding protein family, C-terminal domain (96 - 161)

  • 0
  • 100
  • 168 a.a.
蛋白主名 其他名称

pleiotrophin

heparin affin regulatory protein

PTN 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PTN P21246 ASPH Homo sapiens Q12797-6
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PTN 蛋白

目录号 产品名 蛋白编号 纯度
HY-P700145AF Animal-Free Pleiotrophin Protein, Human (His) P21246 (G33-D168) ≥95%

关联疾病

疾病名称 别名
Nasal Cavity Olfactory Neuroblastoma

Olfactory Neuroblastoma Of The Nasal Cavity

Benign Meningioma

Meningioma, Benign

Common Peroneal Nerve Lesion

Lesion Of Lateral Popliteal Nerve

Fibular Neuropathy

Glioma
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Peyronie'S Disease

Induratio Penis Plastica

Peyronie Disease

Peyronies Disease

Peyronie'S Fibromatosis

Penile Induration

Balanitis Xerotica Obliterans

Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma

Brown-Sequard Syndrome

Brown-Squard Syndrome

Hemicord Syndrome

Hemiparaplegic Syndrome

Hemispinal Cord Syndrome

Brown-Séquard Syndrome

Brain Cancer

Adult Brain Tumor

Malignant Neoplasm Of Brain

Brain Neoplasms

Brain Neoplasm

Neoplasm Of Brain

Primary Malignant Neoplasm Of Brain

Brain Tumors

Adult Malignant Brain Neoplasm

Brain Neoplasm, Adult

Bt - Brain Tumour

Malignant Brain Tumour

Malignant Primary Brain Neoplasm

Malignant Primary Brain Tumor

Malignant Tumor Of Adult Brain

Malignant Tumor Of Brain

Primary Brain Neoplasm

Primary Brain Tumor

Tumor Of The Brain

Brain Tumor, Adult

Brain Tumor Primary

Malignant Primary Brain Tumors

Primary Brain Tumors

Cancer, Brain

Brain Tumor, Primary

Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Meningioma, Familial

Meningioma

Familial Meningioma

Meningioma, Familial, Susceptibility To

Meningeal Neoplasm

Meningeal Neoplasms

Meningiomas

Meningioma, Nf2-Related, Somatic

Meningioma, Sis-Related

Meningothelial Cell Tumor

Neoplasm Of The Meninges

Primary Meningeal Tumor

Familial Multiple Meningioma

MNGMA

Meningioma, Benign, No Icd-O Subtype

Intracranial Meningioma

Meningothelial Cell Neoplasm

Supratentorial Meningioma

Primary Neoplasm Of Spinal Meninges

Benign Intracranial Meningioma

Benign Meningioma

Meningeal Tumours

Meningeal Sarcoma Of Unspecified Site

Meningothelial Sarcoma Of Unspecified Site

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris PTN VGNC VGNC:45160
Mus musculus PTN MGD MGI:97804
Felis catus PTN VGNC VGNC:80664
Macaca mulatta PTN VGNC VGNC:76594
Rattus norvegicus PTN RGD RGD:3444
Bos taurus PTN VGNC VGNC:33521
Others PTN NCBI