2. Gene
  3. CIP2A - cellular inhibitor of PP2A Gene

CIP2A - cellular inhibitor of PP2A Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：PP2A 细胞抑制因子

种属: Homo sapiens

同用名: p90; NOCIVA; KIAA1524

基因 ID: 57650 | 基因类型: protein coding

关于 CIP2A

Cytogenetic location: 3q13.13 Genomic coordinates (GRCh38): 3:108,549,864-108,589,438 (from NCBI)

This gene has 7 transcripts (splice variants), 200 orthologues and 2 paralogues. Broad expression in testis (RPKM 2.5), lymph node (RPKM 2.3) and 22 other tissues.

功能概要

启用蛋白质同源二聚化活性。预计在神经前体细胞增殖和精子发生的正调节上游或正调节内起作用。位于胞质溶胶和质膜中。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein homodimerization activity. Predicted to act upstream of or within positive regulation of neural precursor cell proliferation and spermatogenesis. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

CIP2A 基因产物(1)

mRNA Protein Name
NM_020890.3 NP_065941.2 protein CIP2A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17632056 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
28174209 GOA
enables protein phosphatase inhibitor activity IDA
IDA: 通过直接分析推断
17632056 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response IDA
IDA: 通过直接分析推断
35842428 GOA
involved in broken chromosome clustering IDA
IDA: 通过直接分析推断
37165191 GOA
involved in chromosome organization IDA
IDA: 通过直接分析推断
35121901 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in chromosome IDA
IDA: 通过直接分析推断
35121901 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

protein CIP2A

cancerous inhibitor of PP2A

CIP2A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CIP2A Q8TCG1 PPP2R1A Homo sapiens P30153
Anti Bait CoIP
17632056
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-135699 TD52 ≥95.0% 否
HY-N4317 Ethoxysanguinarine Inducer 99.73% 否
HY-135699A TD52 dihydrochloride 99.90% 否
HY-139296 PP2A Cancerous-IN-1 Inhibitor / 否
HY-RS02718 CIP2A Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CIP2A RGD RGD:1310335
Canis familiaris CIP2A VGNC VGNC:39277
Felis catus CIP2A VGNC VGNC:60906
Bos taurus CIP2A VGNC VGNC:27369
Macaca mulatta CIP2A VGNC VGNC:71371
Mus musculus CIP2A MGD MGI:2146335
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