PTPN7 - protein tyrosine phosphatase non-receptor type 7 Gene

中文名称：7 型蛋白酪氨酸磷酸酶非受体

种属: Homo sapiens

同用名: LPTP; HEPTP; PTPNI; BPTP-4; LC-PTP

关于 PTPN7

功能概要

该基因编码的蛋白质是蛋白酪氨酸磷酸酶 (PTP) 家族的成员。已知 PTP 是调节多种细胞过程的信号分子，包括细胞生长、分化、有丝分裂周期和致癌转化。该基因在多种造血细胞中优先表达，是淋巴因子刺激细胞的早期反应基因。该 PTP 的非催化 N 端可与 MAP 激酶相互作用并抑制 MAP 激酶活性。该 PTP 显示参与 T 细胞抗原受体 (TCR) 信号的调节，该信号被认为通过使与 MAP 激酶途径相关的分子去磷酸化来发挥作用。已发现该基因的多个选择性剪接转录物变体。[RefSeq 提供，2010 年 12 月]

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2010]