CCAR2 - cell cycle and apoptosis regulator 2 Gene

中文名称：细胞周期和凋亡调节因子 2

种属: Homo sapiens

同用名: DBC1; DBC-1; NET35; p30DBC; p30 DBC; KIAA1967

基因 ID: 57805 | 基因类型: protein coding

关于 CCAR2

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:22,604,757-22,621,514 (from NCBI)

This gene has 13 transcripts (splice variants), 137 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 30.7), brain (RPKM 20.0) and 25 other tissues.

功能概要

启用 RNA 聚合酶 II 复合物结合活性和酶抑制剂活性。参与多个过程，包括调节细胞蛋白质代谢过程；调节信号转导；和转录调控，DNA 模板化。位于多种细胞成分中，包括线粒体基质；核质；和主轴。 DBIRD 复合体的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables RNA polymerase II complex binding activity and Enzyme inhibitor activity. Involved in several processes, including regulation of cellular protein metabolic process; regulation of signal transduction; and regulation of transcription, DNA-templated. Located in several cellular components, including mitochondrial matrix; nucleoplasm; and spindle. Part of DBIRD complex. [provided by Alliance of Genome Resources, Apr 2022]

CCAR2 基因产物(4)

mRNA	Protein	Name
NM_001363068.2	NP_001349997.1	cell cycle and apoptosis regulator protein 2 isoform 2
NM_001363069.2	NP_001349998.1	cell cycle and apoptosis regulator protein 2 isoform 2
NM_001393997.1	NP_001380926.1	cell cycle and apoptosis regulator protein 2 isoform 1
NM_021174.6	NP_066997.3	cell cycle and apoptosis regulator protein 2 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables RNA polymerase II complex binding	IDA IDA: 通过直接分析推断	22446626	GOA
enables enzyme binding	IPI IPI: 通过物理相互作用推断	18235501	GOA
enables enzyme inhibitor activity	IDA IDA: 通过直接分析推断	18235501	GOA
enables enzyme inhibitor activity	IMP IMP: 通过突变表型推断	19218236	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17314511	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in RNA splicing	IMP IMP: 通过突变表型推断	22446626	GOA
involved in mitochondrial fragmentation involved in apoptotic process	IDA IDA: 通过直接分析推断	15824730	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	20160719	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: 通过突变表型推断	20074560	GOA
involved in negative regulation of catalytic activity	IMP IMP: 通过突变表型推断	21030595	GOA
involved in negative regulation of cell growth	IMP IMP: 通过突变表型推断	25661920	GOA
involved in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	IMP IMP: 通过突变表型推断	23352644	GOA
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: 通过直接分析推断	23398316	GOA
involved in positive regulation of DNA damage checkpoint	IMP IMP: 通过突变表型推断	23352644	GOA
involved in positive regulation of apoptotic process	IMP IMP: 通过突变表型推断	18235501	GOA
involved in positive regulation of canonical Wnt signaling pathway	IMP IMP: 通过突变表型推断	24824780	GOA
involved in regulation of DNA-templated transcription elongation	IMP IMP: 通过突变表型推断	22446626	GOA
involved in regulation of protein deacetylation	IDA IDA: 通过直接分析推断	21030595	GOA
involved in regulation of protein stability	IDA IDA: 通过直接分析推断	23398316	GOA
involved in response to UV	IMP IMP: 通过突变表型推断	23352644	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of DBIRD complex	IDA IDA: 通过直接分析推断	22446626	GOA
located in chromatin	IDA IDA: 通过直接分析推断	23352644	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	15824730	GOA
located in mitochondrial matrix	IDA IDA: 通过直接分析推断	15824730	GOA
located in nucleus	IDA IDA: 通过直接分析推断	15824730	GOA
located in spindle	IDA IDA: 通过直接分析推断	18445686	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CCAR2 蛋白结构

S1-like

DBC1

0
200
400
600
800
923 a.a.

蛋白主名

其他名称

cell cycle and apoptosis regulator protein 2

cell division cycle and apoptosis regulator protein 2

CCAR2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CCAR2	Q8N163	ZNF335	Homo sapiens	Q9H4Z2	Anti Bait CoIP	19131338
种属内	CCAR2	Q8N163	ZNF335	Homo sapiens	Q9H4Z2	Y2H	19131338
种属内	CCAR2	Q8N163	MYC	Homo sapiens	P01106	Density Sedimentation	17314511
种属内	CCAR2	Q8N163	TTR	Homo sapiens	P02766	Validated Y2H	32814053
种属内	CCAR2	Q8N163	TTR	Homo sapiens	P02766	Y2H Array	32814053
种属内	CCAR2	Q8N163	TTR	Homo sapiens	P02766	Y2H Pooling	32814053
种属内	CCAR2	Q8N163	WFS1	Homo sapiens	O76024	Y2H Array	32814053
种属内	CCAR2	Q8N163	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
种属内	CCAR2	Q8N163	WFS1	Homo sapiens	O76024	Validated Y2H	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

CCAR2 抗体

目录号	产品名	应用	反应物种
HY-P81269	DBC 1 Antibody (YA955)	WB, ICC/IF, IP	Human, Mouse, Rat, Monkey
HY-P81269A	DBC 1 Antibody (YA956)	WB, IHC-F, IHC-P, ICC/IF, IP	Human

关联疾病

疾病名称

别名

Encephalopathy, Neonatal Severe, Due To Mecp2 Mutations

Severe Congenital Encephalopathy Due To Mecp2 Mutation	Severe Neonatal-Onset Encephalopathy With Microcephaly
Encephalopathy, Neonatal Severe	Neonatal Severe Encephalopathy Due To Mecp2 Mutations
Mecp2-Related Severe Neonatal Encephalopathy	Methyl-Cytosine Phosphate Guanine Binding Protein 2 Related Severe Neonatal Encephalopathy
Severe Neonatal Encephalopathy Due To Mecp2 Mutations	ENS-MECP2
Encephalopathy, Neonatal, Severe

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02021	CCAR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	CCAR2	RGD	RGD:1309922
Bos taurus	CCAR2	VGNC	VGNC:26827
Canis familiaris	CCAR2	VGNC	VGNC:38774
Mus musculus	CCAR2	MGD	MGI:2444228
Macaca mulatta	CCAR2	VGNC	VGNC:70611
Felis catus	CCAR2	VGNC	VGNC:60443

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CCAR2 - cell cycle and apoptosis regulator 2 Gene

关于 CCAR2

功能概要

CCAR2 基因产物(4)

CCAR2 蛋白结构

CCAR2 蛋白互作信息

CCAR2 抗体

关联疾病

直系同源

热门区域

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CCAR2 - cell cycle and apoptosis regulator 2 Gene

关于 CCAR2

功能概要

CCAR2 基因产物(4)

CCAR2 蛋白结构

CCAR2 蛋白互作信息

CCAR2 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z