1. Gene
  2. CYP4F11 - cytochrome P450 family 4 subfamily F member 11 Gene

CYP4F11 - cytochrome P450 family 4 subfamily F member 11 Gene

中文名称:细胞色素 P450 家族 4 亚家族 F 成员 11

种属: Homo sapiens

同用名: CYPIVF11

基因 ID: 57834 | 基因类型: protein coding

关于 CYP4F11

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:15,912,377-15,934,867 (from NCBI)

This gene has 5 transcripts (splice variants), 381 orthologues and 12 paralogues. Biased expression in liver (RPKM 19.6), gall bladder (RPKM 11.3) and 11 other tissues.

功能概要

该基因 CYP4F11 编码细胞色素 P450 酶超家族的成员。细胞色素 P450 蛋白是单加氧酶,可催化许多涉及药物代谢和胆固醇、类固醇和其他脂质合成的反应。该基因是 19 号染色体上细胞色素 P450 基因簇的一部分。该家族的另一个成员 CYP4F2 距离大约 16 kb。已发现该基因编码相同蛋白质的可变剪接转录物变体。[RefSeq 提供,2008 年 7 月]

This gene, CYP4F11, encodes a member of the Cytochrome P450 superfamily of Enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and Other lipids. This gene is part of a cluster of Cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F2, is approximately 16 kb away. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

CYP4F11 基因产物(2)

mRNA Protein Name
NM_001128932.2 NP_001122404.1 cytochrome P450 4F11 precursor
NM_021187.4 NP_067010.3 cytochrome P450 4F11 precursor
基因本体论
  • 分子功能
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in fatty acid metabolic process IDA
IDA: 通过直接分析推断
18065749 GOA
involved in menaquinone catabolic process IDA
IDA: 通过直接分析推断
24138531 GOA
involved in omega-hydroxylase P450 pathway IDA
IDA: 通过直接分析推断
15364545 GOA
involved in phylloquinone catabolic process IDA
IDA: 通过直接分析推断
24138531 GOA
involved in vitamin K catabolic process IDA
IDA: 通过直接分析推断
24138531 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CYP4F11 蛋白结构

p450

p450: Cytochrome P450 (52 - 505)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 524 a.a.
蛋白主名 其他名称

cytochrome P450 4F11

3-hydroxy fatty acids omega-hydroxylase CYP4F11

CYP4F11 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CYP4F11 Q9HBI6 MESD Homo sapiens Q14696
Y2H Prey Pooling
32296183
种属内
CYP4F11 Q9HBI6 MESD Homo sapiens Q14696
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Bietti Crystalline Corneoretinal Dystrophy

BCD

Bietti Crystalline Dystrophy

Bietti Tapetoretinal Degeneration With Marginal Corneal Dystrophy

Bietti Crystalline Retinopathy

Bietti'S Crystalline Dystrophy

Crystalline Retinopathy

Dystrophy, Corneoretinal, Crystalline, Bietti

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CYP4F11 RGD RGD:1559596
Macaca mulatta CYP4F11 VGNC VGNC:103612