PTPRK - protein tyrosine phosphatase receptor type K Gene

中文名称：K 型蛋白酪氨酸磷酸酶受体

种属: Homo sapiens

同用名: R-PTP-kappa

关于 PTPRK

功能概要

该基因编码的蛋白质是蛋白酪氨酸磷酸酶 (PTP) 家族的成员。已知 PTP 是调节多种细胞过程的信号分子，包括细胞生长、分化、有丝分裂周期和致癌转化。该 PTP 具有细胞外区域、单个跨膜区域和两个串联催化结构域，因此代表受体型 PTP。细胞外区域包含安眠蛋白-A5 抗原-PTP mu (MAM) 结构域、Ig 样结构域和四个纤连蛋白 III 型样重复序列。该 PTP 显示可介导嗜同性细胞间相互作用，可能是通过与粘附连接处的 β- 和 γ- 连环蛋白相互作用。发现该基因的表达受到 TGF-β1 的刺激，这可能对抑制角质形成细胞增殖很重要。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008]