PTPRR - protein tyrosine phosphatase receptor type R Gene

中文名称：R 型蛋白酪氨酸磷酸酶受体

种属: Homo sapiens

同用名: PTPRQ; EC-PTP; PCPTP1; PTP-SL; PTPBR7

基因 ID: 5801 | 基因类型: protein coding

关于 PTPRR

Cytogenetic location: 12q15 Genomic coordinates (GRCh38): 12:70,638,073-70,920,738 (from NCBI)

This gene has 11 transcripts (splice variants), 198 orthologues and 35 paralogues. Biased expression in brain (RPKM 5.7), colon (RPKM 3.2) and 11 other tissues.

功能概要

该基因编码的蛋白质是蛋白酪氨酸磷酸酶 (PTP) 家族的成员。已知 PTP 是调节多种细胞过程的信号分子，包括细胞生长、分化、有丝分裂周期和致癌转化。该 PTP 具有细胞外区域、单个跨膜区域和单个细胞内催化结构域，因此代表受体型 PTP。该基因的沉默与结直肠癌有关。已发现该基因编码不同异构体的多个转录变体。该基因与另一个基因、蛋白酪氨酸磷酸酶、受体类型 Q (GeneID 374462) 共享一个符号 (PTPRQ) ，后者也位于 12 号染色体上。[RefSeq 提供，2011 年 5 月]

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. Silencing of this gene has been associated with colorectal Cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares a symbol (PTPRQ) with another gene, protein tyrosine Phosphatase, receptor type, Q (GeneID 374462), which is also located on chromosome 12. [provided by RefSeq, May 2011]

PTPRR 基因产物(4)

mRNA	Protein	Name
NM_001207015.2	NP_001193944.1	receptor-type tyrosine-protein phosphatase R isoform 3
NM_001207016.1	NP_001193945.1	receptor-type tyrosine-protein phosphatase R isoform 4
NM_002849.4	NP_002840.2	receptor-type tyrosine-protein phosphatase R isoform 1 precursor
NM_130846.3	NP_570897.2	receptor-type tyrosine-protein phosphatase R isoform 2

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	10601328	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in ERBB2 signaling pathway	IMP IMP: 通过突变表型推断	21724833	GOA
involved in in utero embryonic development	IEP IEP: 通过表达模式推断	10601328	GOA
involved in negative regulation of ERK1 and ERK2 cascade	IMP IMP: 通过突变表型推断	21724833	GOA
involved in negative regulation of epithelial cell migration	IMP IMP: 通过突变表型推断	21724833	GOA
NOT involved in regulation of homophilic cell adhesion	IMP IMP: 通过突变表型推断	21724833	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PTPRR 蛋白结构

Y_phosphatase

0
200
400
600
657 a.a.

蛋白主名

其他名称

receptor-type tyrosine-protein phosphatase R

Ch-1 PTPase

PTPRR 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PTPRR	Q15256	INSR	Homo sapiens	P06213	Ub Reconstruction	28065597
种属内	PTPRR	Q15256	ERBB2	Homo sapiens	P04626	Ub Reconstruction	28065597
种属内	PTPRR	Q15256	MAPK14	Homo sapiens	Q16539	Anti Tag CoIP	33961781
种属内	PTPRR	Q15256	MAPK14	Homo sapiens	Q16539	Phosphatase Assay	10601328
种属内	PTPRR	Q15256	MAPK1	Homo sapiens	P28482	Phosphatase Assay	10601328
种属内	PTPRR	Q15256	MAPK1	Homo sapiens	P28482	IF	10601328
种属内	PTPRR	Q15256	MAPK1	Homo sapiens	P28482	Anti Tag CoIP	33961781

种属间: 跨种属相互作用 种属内: 同种属相互作用

PTPRR 抗体

目录号	产品名	应用	反应物种
HY-P81804	PCPTP1 Antibody (YA1549)	WB	Rat

关联疾病

疾病名称

别名

Deafness, Autosomal Recessive 84a

DFNB84A	Deafness, Autosomal Recessive 84
Autosomal Recessive Nonsyndromic Deafness 84a	Dfnb84
Deafness, Autosomal Recessive 84a, With Vestibular Dysfunction	Autosomal Recessive Deafness 84a
Autosomal Recessive Deafness 84a With Vestibular Dysfunction	Deafness, Autosomal Recessive, 84a
Deafness Autosomal Recessive 84	Deafness Autosomal Recessive 84a With Vestibular Dysfunction
Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 84	Deafness, Autosomal Recessive, Type 84a

Autosomal Recessive Nonsyndromic Deafness 70

Deafness, Autosomal Recessive 70	Autosomal Recessive Deafness 70
Dfnb70	Deafness, Autosomal Recessive, Type 70

Deafness, Autosomal Dominant 2a

DFNA2A	Autosomal Dominant Nonsyndromic Deafness 2a
Autosomal Dominant Deafness 2a	Deafness, Autosomal Dominant, 2a
Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 2a	Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 2a
Deafness, Autosomal Dominant, Type 2a

Deafness, Autosomal Dominant 50

DFNA50	Autosomal Dominant Nonsyndromic Deafness 50
Autosomal Dominant Deafness 50	Deafness, Autosomal Dominant, Type 50

Myopia

Near-Sightedness	Short-Sightedness
Nearsightedness	Nearsighted
Near Vision	Close Sighted
Myopic	Short-Sighted
Near Sighted

Normal Pressure Hydrocephalus

Low Pressure Hydrocephalus	Hydrocephalus Normal Pressure
Hydrocephalus, Normal Pressure	Normal Pressure Hydrocephalus Nos
Nph - [Normal Pressure Hydrocephalus]	Normal Pressure Hydrocephaly

Deafness, Autosomal Recessive 12

DFNB12	Deafness, Autosomal Recessive 12, Modifier Of
Autosomal Recessive Nonsyndromic Deafness 12	Autosomal Recessive Deafness 12
Deafness, Autosomal Recessive, 12	Congenital Neurosensory Deafness Autosomal Recessive 12
Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 12	Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 12
Deafness, Autosomal Recessive, Type 12

Autosomal Recessive Nonsyndromic Deafness

Deafness, Autosomal Recessive, Nonsyndromic

Autosomal Dominant Nonsyndromic Deafness

Autosomal Dominant Deafness

Usher Syndrome

Deafness-Retinitis Pigmentosa Syndrome	Dystrophia Retinae Pigmentosa-Dysostosis Syndrome
Graefe-Usher Syndrome	Hallgren Syndrome
Usher'S Syndrome	Retinitis Pigmentosa-Deafness Syndrome
Retinitis Pigmentosa-Hearing Loss Syndrome	Ush
Usher Syndromes

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-141800	MurA-IN-1	Inhibitor	99.32%	否
HY-RS11448	PTPRR Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	PTPRR	VGNC	VGNC:76621
Felis catus	PTPRR	VGNC	VGNC:69180
Rattus norvegicus	PTPRR	RGD	RGD:620780
Canis familiaris	PTPRR	VGNC	VGNC:45197
Bos taurus	PTPRR	VGNC	VGNC:33557
Mus musculus	PTPRR	MGD	MGI:109559

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PTPRR - protein tyrosine phosphatase receptor type R Gene

关于 PTPRR

功能概要

PTPRR 基因产物(4)

PTPRR 蛋白结构

PTPRR 蛋白互作信息

PTPRR 抗体

关联疾病

直系同源

热门区域

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PTPRR - protein tyrosine phosphatase receptor type R Gene

关于 PTPRR

功能概要

PTPRR 基因产物(4)

PTPRR 蛋白结构

PTPRR 蛋白互作信息

PTPRR 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z