PURA - purine rich element binding protein A Gene

中文名称：富嘌呤元素结合蛋白 A

种属: Homo sapiens

同用名: PUR1; MRD31; NEDRIHF; PURALPHA; PUR-ALPHA

基因 ID: 5813 | 基因类型: protein coding

关于 PURA

Cytogenetic location: 5q31.3 Genomic coordinates (GRCh38): 5:140,114,109-140,125,619 (from NCBI)

This gene has 5 transcripts (splice variants), 243 orthologues, 2 paralogues and is associated with 4 phenotypes.

功能概要

该基因产物是一种序列特异性的单链 DNA 结合蛋白。它优先结合称为 PUR 的富含嘌呤元素的单链，PUR 存在于从酵母到人类的各种真核生物的复制起点和基因侧翼区域。因此，它与 DNA 复制和转录的控制有关。该基因的缺失与骨髓增生异常综合征和急性骨髓性白血病有关。[RefSeq 提供，2008 年 7 月]

This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008]

PURA 基因产物(1)

mRNA	Protein	Name
NM_005859.5	NP_005850.1	transcriptional activator protein Pur-alpha

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables double-stranded telomeric DNA binding	IDA IDA: 通过直接分析推断	15777841	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	7592647	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA unwinding involved in DNA replication	IDA IDA: 通过直接分析推断	15777841	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	26089202	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleus	IDA IDA: 通过直接分析推断	9716182	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PURA 蛋白结构

PurA

0
100
200
300
322 a.a.

蛋白主名

其他名称

transcriptional activator protein Pur-alpha

purine-rich single-stranded DNA-binding protein alpha

PURA 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PURA	Q00577	RB1	Homo sapiens	P06400	Pull Down	7592647
种属内	PURA	Q00577	RB1	Homo sapiens	P06400	Anti Bait CoIP	7592647
种属间	PURA	Q00577	lt_sv40	Simian virus 40	P03070	Pull Down	9830007
种属间	PURA	Q00577	lt_sv40	Simian virus 40	P03070	Pull Down	7592647
种属间	PURA	Q00577	lt_povjc	JC polyomavirus	P03072	Pull Down	9830007
种属间	PURA	Q00577	lt_povjc	JC polyomavirus	P03072	CoIP	9830007

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Neurodevelopmental Disorder With Neonatal Respiratory Insufficiency, Hypotonia, And Feeding Difficulties

NEDRIHF	Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome Due To A Point Mutation
Mental Retardation, Autosomal Dominant 31, Formerly	Mrd31, Formerly
Mrd31

Pura-Related Neurodevelopmental Disorders

Pura Syndrome	Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome
Pura-Related Neurodevelopmental Disorder

5q31.3 Microdeletion Syndrome

Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome Due To 5q31.3 Microdeletion	Del(5)(Q31.3)
Monosomy 5q31.3

Autosomal Dominant Intellectual Developmental Disorder 31

Autosomal Dominant Non-Syndromic Intellectual Disability 31	Autosomal Dominant Mental Retardation 31
Mrd31

X-Linked Hereditary Ataxia

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Fragile X Tremor/Ataxia Syndrome

FXTAS

Fragile X-Associated Tremor/Ataxia Syndrome

Fxtas Syndrome	Fragile X Tremor/Ataxia Syndrome
Fxtas

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Myelodysplastic Syndrome

Myelodysplastic Syndromes	Myelodysplasia
MDS	Myelodysplastic Syndrome Included
Myelodysplastic Syndrome, Susceptibility To, Included	Myelodysplastic Syndrome, Somatic
Myelodysplastic Syndrome, Susceptibility To

Hypotonia

Premature Ovarian Failure 1

Ovarian Failure, Premature	Fmr1-Related Primary Ovarian Insufficiency
Fragile X-Associated Primary Ovarian Insufficiency	POF1
Pofx	Hypergonadotropic Ovarian Failure, X-Linked
Pof	Primary Ovarian Insufficiency, Fragile X-Associated
Primary Ovarian Insufficiency 1	Ovarian Failure Premature
Premature Ovarian Failure, X-Linked	Fragile X Premature Ovarian Failure
Fmr1-Related Premature Ovarian Failure	Familial Premature Ovarian Failure
Idiopathic Familial Premature Ovarian Failure	Fxpoi
X-Linked Hypergonadotropic Ovarian Failure	Hypergonadotropic Ovarian Failure X-Linked
Poi	Premature Ovarian Failure X-Linked
Primary Ovarian Insufficiency	Premature Ovarian Failure-1
Ovarian Failure, Premature, Type 1	Premature Ovarian Failure, Familial
Premature Menopause	Primary Hypogonadism
Turner Syndrome

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 2

FTDALS2	Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-2
Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis, Type 2

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 3

FTDALS3	Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-3
Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis, Type 3

Spinocerebellar Ataxia 8

Spinocerebellar Ataxia Type 8	SCA8
Ataxia, Spinocerebellar, Type 8

Progressive Multifocal Leukoencephalopathy

Pml	Leukoencephalopathy, Progressive Multifocal
Progressive Multifocal Leukoencephalitis	Leukoencephalopathy Progressive Multifocal
Pml - [Progressive Multifocal Leukoencephalopathy]

Huntington Disease-Like 2

HDL2	Huntington'S Disease-Like 2
Huntington Disease-Like, Type 2

Myotonic Dystrophy 2

Myotonic Dystrophy Type 2	Proximal Myotonic Myopathy
Promm	Ricker Syndrome
DM2	Dystrophia Myotonica 2
Myotonic Myopathy, Proximal	Myotonic Disorders
Dystrophia Myotonica Type 2	Proximal Myotonic Dystrophy
Ricker Disease	Myotonic Dystrophy, Type 2
Dystrophy, Myotonic, Type 2

Myotonic Disease

Myotonic Disorders	Myotonic Syndrome
Symptomatic Myotonia

Myotonic Dystrophy 1

Myotonic Dystrophy	Dystrophia Myotonica
Steinert Disease	Myotonic Dystrophy Type 1
Myotonia Atrophica	DM1
Congenital Myotonic Dystrophy	Myotonia Dystrophica
Steinert Myotonic Dystrophy	Dystrophia Myotonica 1
Dm	Steinert'S Disease
Steinert Myotonic Dystrophy Syndrome	Myotonic Dystrophy Of Steinert
Dystrophia Myotonica Type 1	Myotonic Dystrophy Congenital
Dystrophy, Myotonic, Type 1	Dm - [Dystrophia Myotonica]
Myotonic Muscular Dystrophy

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1

FTDALS1	Frontotemporal Dementia And/Or Motor Neuron Disease
Ftdmnd	Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia
Alsftd	Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1	Frontotemporal Dementia With Motor Neuron Disease
Ftdals	Ftd-Als
Ftd-Mnd	Frontotemporal Dementia With Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1	Amyotrophic Lateral Sclerosis/Frontotemporal Dementia
Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1
Frontotemporal Lobar Degeneration	Grn-Related Frontotemporal Dementia

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	是否罕见病
HY-W019894	Manganese chloride		/	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-N10267	Carviolin		/	否
HY-RS11464	PURA Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	PURA	RGD	RGD:1308543
Mus musculus	PURA	MGD	MGI:103079
Bos taurus	PURA	VGNC	VGNC:33572

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站点地图隐私声明

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上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PURA - purine rich element binding protein A Gene

关于 PURA

功能概要

PURA 基因产物(1)

PURA 蛋白结构

PURA 蛋白互作信息

关联疾病

直系同源

热门区域

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PURA - purine rich element binding protein A Gene

关于 PURA

功能概要

PURA 基因产物(1)

PURA 蛋白结构

PURA 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z