2. Gene
  3. JAM2 - junctional adhesion molecule 2 Gene

JAM2 - junctional adhesion molecule 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：连接粘附分子 2

种属: Homo sapiens

同用名: JAMB; CD322; IBGC8; JAM-B; VEJAM; PRO245; VE-JAM; C21orf43

基因 ID: 58494 | 基因类型: protein coding

关于 JAM2

Cytogenetic location: 21q21.3 Genomic coordinates (GRCh38): 21:25,639,258-25,717,562 (from NCBI)

This gene has 7 transcripts (splice variants), 273 orthologues, 14 paralogues and is associated with 2 phenotypes. Broad expression in placenta (RPKM 25.9), brain (RPKM 13.2) and 20 other tissues.

功能概要

该基因属于免疫球蛋白超家族和连接粘附分子 (JAM) 家族。该基因编码的蛋白质是一种 I 型膜蛋白，位于上皮细胞和内皮细胞的紧密连接处。它充当与多种免疫细胞类型相互作用的粘附配体，并可能在淋巴细胞归巢至次级淋巴器官中发挥作用。已发现该基因的可变剪接转录物变体。[RefSeq 提供，2012 年 7 月]

This gene belongs to the immunoglobulin superfamily, and the junctional adhesion molecule (JAM) family. The protein encoded by this gene is a type I membrane protein that is localized at the tight junctions of both epithelial and endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types, and may play a role in lymphocyte homing to secondary lymphoid organs. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2012]

JAM2 基因产物(3)

mRNA Protein Name
NM_001270407.2 NP_001257336.1 junctional adhesion molecule B isoform 2 precursor
NM_001270408.2 NP_001257337.1 junctional adhesion molecule B isoform 3 precursor
NM_021219.4 NP_067042.1 junctional adhesion molecule B isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables integrin binding IDA
IDA: 通过直接分析推断
12070135 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11590146 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell-cell adhesion IMP
IMP: 通过突变表型推断
24357068 GOA
involved in cellular extravasation IDA
IDA: 通过直接分析推断
12239159 GOA
involved in hematopoietic stem cell migration to bone marrow IMP
IMP: 通过突变表型推断
24357068 GOA
involved in leukocyte tethering or rolling IDA
IDA: 通过直接分析推断
19740376 GOA
involved in lymphocyte aggregation IDA
IDA: 通过直接分析推断
11823489 GOA
involved in positive regulation of lymphocyte migration IDA
IDA: 通过直接分析推断
12239159 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
19740376 GOA
located in cell-cell contact zone IDA
IDA: 通过直接分析推断
12239159 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
11590146 GOA
located in plasma membrane IMP
IMP: 通过突变表型推断
31851307 GOA
part of protein complex involved in cell adhesion IDA
IDA: 通过直接分析推断
11590146 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

JAM2 蛋白结构

V-set

V-set: Immunoglobulin V-set domain (35 - 118)

I-set

I-set: Immunoglobulin I-set domain (145 - 223)

  • 0
  • 100
  • 200
  • 298 a.a.
蛋白主名 其他名称

junctional adhesion molecule B

JAM-2

JAM2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
JAM2 P57087 JAM3 Homo sapiens Q9BX67
Protein Array
21982860
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 JAM2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70385 JAM-B/CD322 Protein, Human (HEK293, His) P57087-1 (F29-N236) ≥95%

关联疾病

疾病名称 别名
Basal Ganglia Calcification, Idiopathic, 8, Autosomal Recessive

IBGC8
Basal Ganglia Calcification, Idiopathic, 1

Primary Familial Brain Calcification

Pfbc

Bspdc

Bilateral Striopallidodentate Calcinosis

Cerebrovascular Ferrocalcinosis

IBGC1

Familial Idiopathic Basal Ganglia Calcification

Idiopathic Basal Ganglia Calcification 1

Striopallidodentate Calcinosis, Bilateral

Striopallidodentate Calcinosis, Autosomal Dominant, Adult-Onset

Cerebral Calcification, Nonarteriosclerotic, Idiopathic, Adult-Onset

Ferrocalcinosis, Cerebrovascular

Fahr Disease, Familial, Formerly

Basal Ganglia Calcification, Idiopathic, 3, Formerly

Ibgc3, Formerly

Basal Ganglia Calcification, Idiopathic, 2, Formerly

Ibgc2, Formerly

Fibgc

Striopallidodentate Calcinosis

Idiopathic Basal Ganglia Calcification

Ferrocalcinosis Cerebro Vascular

Autosomal Dominant Adult-Onset Striopallidodentate Calcinosis

Familial Fahr Disease

Ibgc2

Ibgc3

Idiopathic Basal Ganglia Calcification 2

Idiopathic Basal Ganglia Calcification 3

Non-Arteriosclerotic, Idiopathic, Adult-Onset Cerebral Calcification

Basal Ganglia Calcification, Idiopathic

Calcification, Basal Ganglia, Idiopathic

Calcification, Basal Ganglia, Idiopathic, Type 1

Fahr'S Syndrome
Basal Ganglia Calcification

Fahr'S Syndrome

Fahr'S Disease

Fahr Disease
Neurogenic Bowel
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07027 JAM2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus JAM2 MGD MGI:1933820
Rattus norvegicus JAM2 RGD RGD:1561692
Felis catus JAM2 VGNC VGNC:63001
Bos taurus JAM2 VGNC VGNC:50011
Canis familiaris JAM2 VGNC VGNC:53029
Macaca mulatta JAM2 VGNC VGNC:73831
Others JAM2 NCBI
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