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  2. RAB1A - RAB1A, member RAS oncogene family Gene

RAB1A - RAB1A, member RAS oncogene family Gene

中文名称:RAB1A,成员 RAS 致癌基因家族

种属: Homo sapiens

同用名: RAB1; YPT1

基因 ID: 5861 | 基因类型: protein coding

关于 RAB1A

Cytogenetic location: 2p14 Genomic coordinates (GRCh38): 2:65,086,854-65,130,106 (from NCBI)

This gene has 6 transcripts (splice variants), 163 orthologues and 68 paralogues. Ubiquitous expression in kidney (RPKM 68.0), thyroid (RPKM 58.5) and 25 other tissues.

功能概要

该基因编码 GTP 酶 Ras 超家族的成员。基因家族成员在非活性 GDP 结合和活性 GTP 结合形式之间循环。这种小 GTPase 控制从内质网到高尔基体的囊泡交通。已经为该基因鉴定了多个选择性剪接的转录物变体,它们编码不同的蛋白质同种型。[RefSeq 提供,2008 年 10 月]

This gene encodes a member of the Ras superfamily of GTPases. Members of the gene family cycle between inactive GDP-bound and active GTP-bound forms. This small GTPase controls vesicle traffic from the endoplasmic reticulum to the Golgi apparatus. Multiple alternatively spliced transcript variants have been identified for this gene which encode different protein isoforms. [provided by RefSeq, Oct 2008]

RAB1A 基因产物(2)

mRNA Protein Name
NM_004161.5 NP_004152.1 ras-related protein Rab-1A isoform 1
NM_015543.2 NP_056358.1 ras-related protein Rab-1A isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTPase activity IDA
IDA: 通过直接分析推断
17684057 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15186776 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in COPII-coated vesicle cargo loading IMP
IMP: 通过突变表型推断
17684057 GOA
involved in Golgi organization IMP
IMP: 通过突变表型推断
17684057 GOA
involved in autophagosome assembly IMP
IMP: 通过突变表型推断
22939626 GOA
involved in autophagy IMP
IMP: 通过突变表型推断
22939626 GOA
involved in cell migration IMP
IMP: 通过突变表型推断
20639577 GOA
NOT involved in cilium assembly IMP
IMP: 通过突变表型推断
17646400 GOA
involved in defense response to bacterium IMP
IMP: 通过突变表型推断
22939626 GOA
involved in endocytosis IMP
IMP: 通过突变表型推断
21303926 GOA
involved in endoplasmic reticulum to Golgi vesicle-mediated transport IGI
IGI: 通过遗传相互作用推断
21680502 GOA
involved in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
IMP: 通过突变表型推断
17684057 GOA
NOT involved in establishment of endothelial intestinal barrier IMP
IMP: 通过突变表型推断
23885123 GOA
involved in growth hormone secretion IMP
IMP: 通过突变表型推断
22939626 GOA
involved in positive regulation of glycoprotein metabolic process IGI
IGI: 通过遗传相互作用推断
21680502 GOA
involved in positive regulation of interleukin-8 production IMP
IMP: 通过突变表型推断
22939626 GOA
involved in vesicle transport along microtubule IMP
IMP: 通过突变表型推断
21303926 GOA
involved in virion assembly IGI
IGI: 通过遗传相互作用推断
21680502 GOA
involved in virion assembly IMP
IMP: 通过突变表型推断
21680502 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in endoplasmic reticulum IDA
IDA: 通过直接分析推断
17684057 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RAB1A 蛋白结构

Ras

Ras: Ras family (13 - 173)

  • 0
  • 100
  • 205 a.a.
蛋白主名 其他名称

ras-related protein Rab-1A

GTP binding protein Rab1a

RAB1A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RAB1A P62820 RPTOR Homo sapiens Q8N122
Anti Bait CoIP
25446900
种属内
RAB1A P62820 RPTOR Homo sapiens Q8N122
Anti Tag CoIP
25446900
种属内
RAB1A P62820 RPTOR Homo sapiens Q8N122
PLA
25446900
种属间
RAB1A P62820 drrA Legionella pneumophila Q29ST3
Anti Tag CoIP
30323948
种属内
RAB1A P62820 C9orf72 Homo sapiens Q96LT7-1
Pull Down
27334615
种属内
RAB1A P62820 C9orf72 Homo sapiens Q96LT7-1
Anti Tag CoIP
27334615
种属内
RAB1A P62820 C9orf72 Homo sapiens Q96LT7-2
Anti Tag CoIP
27334615
种属内
RAB1A P62820 C9orf72 Homo sapiens Q96LT7-2
Pull Down
27334615
种属内
RAB1A P62820 MTOR Homo sapiens P42345
Anti Bait CoIP
25446900
种属内
RAB1A P62820 MTOR Homo sapiens P42345
Anti Tag CoIP
25446900
种属内
RAB1A P62820 MTOR Homo sapiens P42345
PLA
25446900
种属内
RAB1A P62820 OCRL Homo sapiens Q01968
Pull Down
16902405
种属内
RAB1A P62820 RABIF Homo sapiens P47224
Anti Tag CoIP
33961781
种属内
RAB1A P62820 RABIF Homo sapiens P47224
Y2H Array
32296183
种属间
RAB1A P62820 drrA Legionella pneumophila subsp. pneumophila Q5ZSQ3
Comig Non-Denat Gel
19942850
种属间
RAB1A P62820 drrA Legionella pneumophila subsp. pneumophila Q5ZSQ3
X-Ray Diffraction
19942850
种属间
RAB1A P62820 drrA Legionella pneumophila subsp. pneumophila Q5ZSQ3
ITC
19942850
种属内
RAB1A P62820 GDI1 Homo sapiens P31150
Anti Tag CoIP
35271311
种属内
RAB1A P62820 GDI1 Homo sapiens P31150
Pull Down
19942850
种属内
RAB1A P62820 GDI1 Homo sapiens P31150
Anti Tag CoIP
33961781
种属内
RAB1A P62820 GDI1 Homo sapiens P31150
Anti Tag CoIP
28514442
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Choroideremia

CHM

Tcd

Progressive Tapetochoroidal Dystrophy

Choroidal Sclerosis

Tapetochoroidal Dystrophy, Progressive

Progressive Choroidal Atrophy

Tapetochoroidal Dystrophy

Spinocerebellar Ataxia, Autosomal Recessive 6

SCAR6

Norwegian Infantile Onset Ataxia

Autosomal Recessive Spinocerebellar Ataxia 6

Autosomal Recessive Spinocerebellar Ataxia Type 6

Infantile-Onset Autosomal Recessive Nonprogressive Cerebellar Ataxia

Cerebellar Ataxia, Infantile Nonprogressive, Autosomal Recessive

Spinocerebellar Ataxia Autosomal Recessive 6

Cerebellar Ataxia Infantile Nonprogressive Autosomal Recessive

Legionellosis

Legionella Infection

Pontiac Fever

Legionnaires' Disease

Infection By Legionella Pneumophilia

Legionella Pneumophila Infection

Esophageal Neuroendocrine Tumor

Esophageal Neuroendocrine Tumour

Neuroendocrine Tumor Of Esophagus

Neuroendocrine Tumour Of Oesophagus

Legionnaire Disease

Legionnaires' Disease

Legionnaires Disease

Legionnaire Disease, Susceptibility To

Legionella

Legionella Pneumonia

Infection By Legionella Pneumophilia

Legionnaire'S Disease

Legionellosis

Legionaire Disease, Susceptibility To

Legionnaires Pneumonia

Rectum Adenocarcinoma

Rectal Adenocarcinoma

Adenocarcinoma Of Rectum

Rectal Benign Neoplasm

Neoplasm Of Rectum

Rectal Tumor

Rectum Neoplasm

Neoplasm Of The Rectum

Rectal Neoplasms

Primary Rectal Cancer

Rectal Ampulla Cancer

Cancer Of The Rectum

Carcinoma Of Rectum

Primary Malignant Neoplasm Of Rectum

Rectal Cancer

Rectal Carcinoma

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1

FTDALS1

Frontotemporal Dementia And/Or Motor Neuron Disease

Ftdmnd

Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia

Alsftd

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1

Frontotemporal Dementia With Motor Neuron Disease

Ftdals

Ftd-Als

Ftd-Mnd

Frontotemporal Dementia With Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1

Amyotrophic Lateral Sclerosis/Frontotemporal Dementia

Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1

Frontotemporal Lobar Degeneration

Grn-Related Frontotemporal Dementia

Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta RAB1A VGNC VGNC:106204
Bos taurus RAB1A VGNC VGNC:33626
Felis catus RAB1A VGNC VGNC:81164
Mus musculus RAB1A MGD MGI:97842
Canis familiaris RAB1A VGNC VGNC:45259
Rattus norvegicus RAB1A RGD RGD:619736