1. Gene
  2. RGL2 - ral guanine nucleotide dissociation stimulator like 2 Gene

RGL2 - ral guanine nucleotide dissociation stimulator like 2 Gene

中文名称:ral 鸟嘌呤核苷酸解离刺激物 2

种属: Homo sapiens

同用名: KE1.5; RAB2L; HKE1.5

基因 ID: 5863 | 基因类型: protein coding

关于 RGL2

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:33,291,654-33,301,612 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele, 100 orthologues and 24 paralogues. Ubiquitous expression in spleen (RPKM 40.1), prostate (RPKM 26.5) and 25 other tissues.

功能概要

预测可启用胍基核苷酸交换因子活性。预测参与调节催化活性和小 GTPase 介导的信号转导。预测作用于心肌细胞凋亡过程的上游或负调节内;磷脂酰肌醇 3-激酶信号的正向调控;和 Ral 蛋白信号转导的调节。预测位于胞质溶胶中。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of catalytic activity and small GTPase mediated signal transduction. Predicted to act upstream of or within negative regulation of cardiac muscle cell apoptotic process; positive regulation of phosphatidylinositol 3-kinase signaling; and regulation of Ral protein signal transduction. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

RGL2 基因产物(2)

mRNA Protein Name
NM_001243738.2 NP_001230667.1 ral guanine nucleotide dissociation stimulator-like 2 isoform 2
NM_004761.5 NP_004752.1 ral guanine nucleotide dissociation stimulator-like 2 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
20936779 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RGL2 蛋白结构

RasGEF_N

RasGEF_N: RasGEF N-terminal motif (92 - 141)

  • 0
  • 100
  • 146 a.a.
蛋白主名 其他名称

ral guanine nucleotide dissociation stimulator-like 2

GDS-related protein

RGL2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RGL2 O15211 KRTAP10-8 Homo sapiens P60410 32296183
种属内
RGL2 O15211 KRTAP10-8 Homo sapiens P60410 32296183
种属内
RGL2 O15211 KRTAP10-8 Homo sapiens P60410 32296183
种属内
RGL2 O15211 ADAMTSL4 Homo sapiens Q6UY14-3 32296183
种属内
RGL2 O15211 ADAMTSL4 Homo sapiens Q6UY14-3 32296183
种属内
RGL2 O15211 ADAMTSL4 Homo sapiens Q6UY14-3 32296183
种属内
RGL2 O15211 KPRP Homo sapiens Q5T749 32296183
种属内
RGL2 O15211 KPRP Homo sapiens Q5T749 32296183
种属内
RGL2 O15211 KPRP Homo sapiens Q5T749 32296183
种属内
RGL2 O15211 HRAS Homo sapiens P01112 20936779
种属内
RGL2 O15211 CYSRT1 Homo sapiens A8MQ03 32296183
种属内
RGL2 O15211 CYSRT1 Homo sapiens A8MQ03 32296183
种属内
RGL2 O15211 GORASP2 Homo sapiens Q9H8Y8 32296183
种属内
RGL2 O15211 GORASP2 Homo sapiens Q9H8Y8 32296183
种属内
RGL2 O15211 GORASP2 Homo sapiens Q9H8Y8 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Tumoral Calcinosis, Normophosphatemic, Familial

Normophosphatemic Familial Tumoral Calcinosis

NFTC

Tumoral Calcinosis, Familial, Normophosphatemic

Calcinosis, Tumoral, With Normophosphatemia

Familial Normophosphatemic Tumoral Calcinosis

Tumoral Calcinosis With Normophosphatemia

Calcinosis

Pathologic Calcification

Pathologically Calcified Structure

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta RGL2 VGNC VGNC:76886
Bos taurus RGL2 VGNC VGNC:33904
Rattus norvegicus RGL2 RGD RGD:1302985
Canis familiaris RGL2 VGNC VGNC:45513
Mus musculus RGL2 MGD MGI:107483
Others RGL2 NCBI