IL21 - interleukin 21 Gene

中文名称：白细胞介素 21

种属: Homo sapiens

同用名: Za11; IL-21; CVID11

基因 ID: 59067 | 基因类型: protein coding

关于 IL21

Cytogenetic location: 4q27 Genomic coordinates (GRCh38): 4:122,610,108-122,621,066 (from NCBI)

This gene has 3 transcripts (splice variants), 113 orthologues and is associated with 2 phenotypes. Biased expression in lymph node (RPKM 3.2), testis (RPKM 0.8) and 2 other tissues.

功能概要

该基因编码具有免疫调节活性的共同γ链细胞因子家族成员。编码的蛋白质通过诱导包括巨噬细胞、自然杀伤细胞、B 细胞和细胞毒性 T 细胞在内的多种靶细胞的分化、增殖和活性，在先天性和适应性免疫反应中发挥作用。该基因的失调在多种免疫介导的疾病中发挥作用，包括狼疮、牛皮癣和慢性炎症性疾病。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 12 月]

This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

IL21 基因产物(2)

mRNA	Protein	Name
NM_001207006.3	NP_001193935.1	interleukin-21 isoform 2 precursor
NM_021803.4	NP_068575.1	interleukin-21 isoform 1 precursor

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables interleukin-2 receptor binding	IPI IPI: 通过物理相互作用推断	12504082	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cell maturation	IDA IDA: 通过直接分析推断	14635054	GOA
acts upstream of or within positive regulation of B cell proliferation	IDA IDA: 通过直接分析推断	17673207	GOA
acts upstream of or within positive regulation of T cell proliferation	IDA IDA: 通过直接分析推断	17673207	GOA
involved in positive regulation of T cell proliferation	IDA IDA: 通过直接分析推断	15207081	GOA
acts upstream of or within positive regulation of cell population proliferation	IDA IDA: 通过直接分析推断	17673207	GOA
involved in positive regulation of cytokine production	IDA IDA: 通过直接分析推断	19322899	GOA
involved in positive regulation of interleukin-17 production	IDA IDA: 通过直接分析推断	16482511	GOA
involved in positive regulation of natural killer cell mediated cytotoxicity	IDA IDA: 通过直接分析推断	18005035	GOA
acts upstream of or within positive regulation of tyrosine phosphorylation of STAT protein	IDA IDA: 通过直接分析推断	17673207	GOA
involved in tyrosine phosphorylation of STAT protein	IDA IDA: 通过直接分析推断	12244150	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IL21 蛋白结构

IL15

0
100
162 a.a.

蛋白主名

其他名称

interleukin-21

重组 IL21 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7038	IL-21 Protein, Human	Q9HBE4-1 (Q32-S162)	≥95%
HY-P7038G	GMP IL-21 Protein, Human	Q9HBE4-1 (Q30-S162)	≥95%
HY-P78148	IL-21 Protein, Human (His-Avi)	Q9HBE4-1 (Q32-S162)	≥95%
HY-P700112AF	Animal-Free IL-21 Protein, Human (His)	Q9HBE4-1 (Q32-S162)	≥95%

关联疾病

疾病名称

别名

Immunodeficiency, Common Variable, 11

Il21-Related Infantile Inflammatory Bowel Disease	CVID11
Il21 Deficiency	Common Variable Immunodeficiency 11
Il21-Related Infantile Ibd	Immunodeficiency, Variable, Common, Type 11

Severe Combined Immunodeficiency, X-Linked

X-Linked Severe Combined Immunodeficiency	SCIDX1
XSCID	Scidx
X-Linked Scid	X-Scid
Severe Combined Immunodeficiency, X-Linked, T Cell-Negative, B Cell-Positive, Nk Cell-Negative	Scid, X-Linked
Immunodeficiency 4	Imd4
Gamma Chain Deficiency	Scid-X1
X-Linked Combined Immunodeficiency Diseases	Thymic Epithelial Hypoplasia
Severe Combined Immunodeficiency T- B+ Due To Gamma Chain Deficiency	Severe Combined Immunodeficiency T- B+, X-Linked
Il2rg Scid, T- B+ Nk-	T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency
T-B+ Scid Due To Gamma Chain Deficiency	T-B+ Severe Combined Immunodeficiency, X-Linked
Severe Combined Immunodeficiency X-Linked T-Cell-Negative/B-Cell-Positive/Nk-Cell-Negative	Agammaglobulinemia Swiss Type
Scid X-Linked	Severe Combined Immunodeficiency X-Linked T Cell-Negative/B Cell-Positive/Nk Cell-Negative
Severe Combined Immunodeficiency X-Linked T-Cell Negative/B-Cell Positive/Nk-Cell Negative	Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Epidermolysis Bullosa Acquisita

Acquired Epidermolysis Bullosa	Eb Acquisita
Eba	Eba - [Epidermolysis Bullosa Acquisita]

Autoimmune Disease

Autoimmune Diseases	Autoimmune Hypersensitivity Disease
Hypersensitivity Reaction Type Ii Disease	Type Ii Hypersensitivity Reaction Disease

Severe Combined Immunodeficiency

Scid	Severe Combined Immunodeficiency Disease
Combined T And B Cell Inborn Immunodeficiency	Immunodeficiency, Severe Combined
Scid - [Severe Combined Immunodeficiencies]

Psoriasis

Common Variable Immunodeficiency

Cvid	Common Variable Agammaglobulinemia
Common Variable Immune Deficiency	Acquired Hypogammaglobulinemia
Hypogamma-Globulinemia, Acquired	Idiopathic Immunoglobulin Deficiency
Primary Antibody Deficiency	Primary Hypogammaglobulinemia
Acquired Agammaglobulinemia	Sporadic Hypogammaglobulinemia
Common Variable Hypogamma-Globulinemia	Immunoglobulin Deficiency, Late-Onset
Common Variable Hypogammaglobulinemia	Immunodeficiency, Common Variable

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency	Congenital Combined Immunodeficiency
Syndrome With Combined Immunodeficiency	Combined T And B Cell Immunodeficiency
Combined Immunity Deficiency	Combined Immunodeficiency Syndrome
Combined T-Cell And B-Cell Immunodeficiency	Lymphopenic Agammaglobulinaemia

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-P99451	Avizakimab	Inhibitor	99.35%	Phase 2
HY-P99687	Latikafusp	Inhibitor	99.00%	Phase 1

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-162490	TF-S14	Inhibitor	/	否
HY-RS06734	IL21 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS06735	IL21R Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	IL21	VGNC	VGNC:73726
Rattus norvegicus	IL21	RGD	RGD:1307384
Bos taurus	IL21	VGNC	VGNC:30141
Felis catus	IL21	VGNC	VGNC:67774
Mus musculus	IL21	MGD	MGI:1890474
Canis familiaris	IL21	VGNC	VGNC:41967
Macaca fascicularis	IL21	NCBI	NCBI:102130762
Others	IL21	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

IL21 - interleukin 21 Gene

关于 IL21

功能概要

IL21 基因产物(2)

IL21 蛋白结构

重组 IL21 蛋白

关联疾病

直系同源

热门区域

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IL21 - interleukin 21 Gene

关于 IL21

功能概要

IL21 基因产物(2)

IL21 蛋白结构

重组 IL21 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z