2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. Latikafusp

Latikafusp  (Synonyms: AMG 256)

目录号: HY-P99687 纯度: 99.00%
COA

摩尔计算器

Latikafusp (AMG 256) 是一种双功能融合蛋白，包含靶向 PD-1 的抗体和 IL-21 突变蛋白，旨在向 PD-1+ 细胞提供 IL-21 通路刺激。Latikafusp 可以启动和延长细胞毒性和记忆 T 细胞的活性，并诱导抗肿瘤免疫。Latikafusp 具有用于实体瘤研究的潜力。Latikafusp 可导致免疫原性介导的反应的产生。

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CAS No. : 2552814-07-8

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规格 价格 是否有货 数量
500 μg ￥4050
In-stock
1 mg ￥6500
In-stock
5 mg   询价  
10 mg   询价  

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Customer Review

Latikafusp 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Latikafusp (AMG 256) is a bifunctional fusion protein comprising a PD-1-targeting antibody and IL-21 mutein designed to deliver IL-21 pathway stimulation to PD-1+ cells. Latikafusp is designed to prime and extend the activity of cytotoxic and memory T cells and induce anti-tumor immunity. Latikafusp has the potential for solid tumors research[1][2].Latikafusp may lead to the development of immunogenicity-mediated responses[3].

同型

Human IgG1 lambda1
推荐同型对照抗体
种属

Human
体内研究
(In Vivo)

Latikafusp (5 mg/kg; 在第 1 天和第 15 天用药; i.v.) 让 cynomolgus monkeys 出现了较强的免疫原性反应和超敏反应[3]。
Latikafusp (10, 30 mg/kg; 三周内每周服用一次; i.v.) 可以激活经典和替代补体途径[3]。
Latikafusp (10, 30 mg/kg; 周内每周服用一次 i.v.) 让所有剂量组的 cynomolgus monkeys 均表现出强烈的抗体反应，提示该药物具有较高的免疫原性[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cynomolgus monkeys [3]
Dosage: 5 mg/kg; administered on days 1 and 15
Administration: i.v.
Result: Elicited a strong immunogenic response in all animals, as evidenced by the presence of anti-Latikafusp IgG antibodies on days 15 and 25 following the initial dose administration.
Compared to the 22D4 group alone, the antibody response was significantly higher.
Animal Model: Cynomolgus monkeys [3]
Dosage: 10, 30 mg/kg; Weekly doses over three weeks
Administration: i.v.
Result: Induced the development of anti-Latikafusp IgG antibodies in all animals by day 19, demonstrating a strong immune response to the therapeutic protein.
Administration in high doses led to severe adverse reactions and immunogenic complications, underscoring critical safety concerns associated with its use.
Animal Model: Cynomolgus monkeys [3]
Dosage: 0, 6, 30, or 150 mg/kg; Weekly doses over four weeks
Administration: i.v.
Result: At the highest dose of 150 mg/kg, caused severe clinical signs in animals, including weakness, petechiae, hypothermia, and dehydration, which led to the unscheduled euthanasia of several animals.
Additionally, at high doses was linked to immunogenicity-related complications, such as thrombocytopenia and consumptive coagulopathy.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 lambda
Biological Activity
  • Loaded Latikafusp on HIS1K biosensor, can bind PD-1 Protein, Human (HEK293, His-Fc, HY-P73345) with an affinity constant of 9.162E-11 M as determined in BLI assay.
纯度 & 产品资料

纯度: 99.00%

COA (264 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Latikafusp 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Latikafusp2552814-07-8AMG 256AMG256AMG-256PD-1/PD-L1PD-1/Programmed death-ligand 1BifunctionalPD-1antibodyIL-21 muteincytotoxicmemory T cellsolid tumorsInhibitorinhibitorinhibit

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