RBBP7 - RB binding protein 7, chromatin remodeling factor Gene

中文名称：RB 结合蛋白 7，染色质重塑因子

种属: Homo sapiens

同用名: RbAp46

关于 RBBP7

功能概要

该蛋白是一种普遍表达的核蛋白，属于 WD 重复蛋白的高度保守亚家族。它存在于几种直接结合视网膜母细胞瘤蛋白的蛋白质中，后者调节细胞增殖。编码的蛋白质存在于许多组蛋白脱乙酰酶复合物中，包括 mSin3 辅阻遏物复合物。它也存在于参与染色质组装的蛋白质复合物中。这种蛋白质可以与 BRCA1 肿瘤抑制基因相互作用，并可能在细胞增殖和分化的调节中发挥作用。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2010 年 11 月]

This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]