MTA2 - metastasis associated 1 family member 2 Gene

中文名称：转移相关 1 家族成员 2

种属: Homo sapiens

同用名: PID; MTA1L1

关于 MTA2

功能概要

该基因编码的蛋白质已被确定为 NuRD 的一个组成部分，NuRD 是一种在人类细胞核中发现的核小体重塑脱乙酰酶复合物。它表现出非常广泛的表达模式，并在许多组织中强烈表达。它可能代表一个小基因家族的成员，该家族编码直接或间接参与转录调控的不同但相关的蛋白质。它们对转录调控的间接影响可能包括染色质重塑。它与该家族的另一个成员密切相关，后者是一种与某些癌的转移潜能相关的蛋白质。这两种蛋白质关系密切，以至于它们共享相同类型的结构域。这些结构域包括两个 DNA 结合结构域、一个二聚化结构域和一个常见于甲基化 DNA 的蛋白质中的结构域。已知作为该基因产物的靶蛋白的一种蛋白质是 p53。 p53 的去乙酰化与转化细胞中生长抑制的丧失相关，支持这些基因家族成员与转移之间的联系。[RefSeq 提供，2011 年 5 月]

This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [provided by RefSeq, May 2011]