RIT2 - Ras like without CAAX 2 Gene

中文名称：没有 CAAX 2 的 Ras

种属: Homo sapiens

同用名: RIN; RIBA; ROC2

基因 ID: 6014 | 基因类型: protein coding

关于 RIT2

Cytogenetic location: 18q12.3 Genomic coordinates (GRCh38): 18:42,743,227-43,115,685 (from NCBI)

This gene has 5 transcripts (splice variants), 102 orthologues and 35 paralogues. Biased expression in brain (RPKM 5.4) and adrenal (RPKM 0.9).

功能概要

RIN 属于小 GTP 酶的 Ras (HRAS; MIM 190020) 超家族 (Shao 等人，1999 [PubMed 10545207]) 。[OMIM 提供，2008 年 3 月]

RIN belongs to the Ras (HRAS; MIM 190020) superfamily of small GTPases (Shao et al., 1999 [PubMed 10545207]).[supplied by OMIM, Mar 2008]

RIT2 基因产物(2)

mRNA	Protein	Name
NM_001272077.2	NP_001259006.1	GTP-binding protein Rit2 isoform 2
NM_002930.4	NP_002921.1	GTP-binding protein Rit2 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables calmodulin binding	IDA IDA: 通过直接分析推断	8918462	GOA
NOT enables identical protein binding	IDA IDA: 通过直接分析推断	21957239	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	21957239	GOA
enables semaphorin receptor binding	IPI IPI: 通过物理相互作用推断	16122393	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in intracellular signal transduction	IDA IDA: 通过直接分析推断	21957239	GOA
involved in maintenance of protein location in cell	IMP IMP: 通过突变表型推断	21957239	GOA
involved in positive regulation of neuron projection development	IGI IGI: 通过遗传相互作用推断	16157584	GOA
involved in regulation of endocytosis	IMP IMP: 通过突变表型推断	21957239	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in membrane raft	IDA IDA: 通过直接分析推断	21957239	GOA
located in neuron projection	IDA IDA: 通过直接分析推断	21957239	GOA
located in nucleus	IDA IDA: 通过直接分析推断	16122393	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	16122393	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RIT2 蛋白结构

Ras

0
100
200
217 a.a.

蛋白主名

其他名称

GTP-binding protein Rit2

GTP-binding protein Roc2

RIT2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	RIT2	Q99578	SLC6A3	Homo sapiens	Q01959	FRET	21957239

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Amyotrophic Lateral Sclerosis, Juvenile, With Dementia

Juvenile Amyotrophic Lateral Sclerosis With Dementia

Als-Dementia Complex

Immunodeficiency 18

IMD18	Cd3-Epsilon Deficiency
Immunodeficiency 18, Scid Variant	Cd3epsilon Deficiency
Immunodeficiency 18, Severe Combined Immunodeficiency Variant	Immunodeficiency, Type 18

Ehrlichiosis

Human Ehrlichiosis	He
Hey

Balo Concentric Sclerosis

Balo'S Concentric Sclerosis	Balo Disease
Diffuse Cerebral Sclerosis Of Schilder	Tumefactive Multiple Sclerosis
Concentric Demyelination	Balo'S Disease
Baló Concentric Sclerosis	Encephalitis Periaxialis Concentrica
Marburg Variant

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12004	RIT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	RIT2	VGNC	VGNC:45601
Macaca mulatta	RIT2	VGNC	VGNC:104243
Felis catus	RIT2	VGNC	VGNC:64645
Rattus norvegicus	RIT2	RGD	RGD:1307654
Mus musculus	RIT2	MGD	MGI:108054

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

RIT2 - Ras like without CAAX 2 Gene

关于 RIT2

功能概要

RIT2 基因产物(2)

RIT2 蛋白结构

RIT2 蛋白互作信息

关联疾病

直系同源

热门区域

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RIT2 - Ras like without CAAX 2 Gene

关于 RIT2

功能概要

RIT2 基因产物(2)

RIT2 蛋白结构

RIT2 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z