2. Gene
  3. Nsf - N-ethylmaleimide sensitive factor, vesicle fusing ATPase Gene

Nsf - N-ethylmaleimide sensitive factor, vesicle fusing ATPase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 60355 | 基因类型: protein coding

关于 Nsf

功能概要

Enables several functions, including ATP hydrolysis activity; ATP-dependent protein binding activity; and signaling receptor binding activity. Involved in several processes, including protein transport; protein-containing complex disassembly; and regulation of vesicle-mediated transport. Located in Golgi stack; dendritic shaft; and postsynaptic density. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy. Orthologous to human NSF (N-ethylmaleimide sensitive factor, vesicle fusing ATPase). [provided by Alliance of Genome Resources, Apr 2022]

Nsf 基因产物(1)

mRNA Protein Name
NM_021748.2 NP_068516.2 vesicle-fusing ATPase
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP hydrolysis activity IDA
IDA: 通过直接分析推断
11062069 RGD
enables ATP-dependent protein binding IPI
IPI: 通过物理相互作用推断
11062069 RGD
enables D1 dopamine receptor binding IPI
IPI: 通过物理相互作用推断
20623535 RGD
enables ionotropic glutamate receptor binding IPI
IPI: 通过物理相互作用推断
12130635 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
9697854 RGD
enables protein serine/threonine kinase binding IPI
IPI: 通过物理相互作用推断
20802490 RGD
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
11931741 RGD
enables small GTPase binding IPI
IPI: 通过物理相互作用推断
11062069 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of receptor-mediated endocytosis IMP
IMP: 通过突变表型推断
21807099 RGD
involved in protein-containing complex disassembly IDA
IDA: 通过直接分析推断
11931741 RGD
involved in regulation of exocytosis IMP
IMP: 通过突变表型推断
11245593 RGD
involved in regulation of receptor internalization IDA
IDA: 通过直接分析推断
11931741 RGD
involved in vesicle-mediated transport IMP
IMP: 通过突变表型推断
11245593 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in GABA-ergic synapse IDA
IDA: 通过直接分析推断
11461150 RGD
located in Golgi stack IDA
IDA: 通过直接分析推断
11062069 RGD
located in dendritic shaft IDA
IDA: 通过直接分析推断
1041498 RGD
is active in postsynaptic specialization, intracellular component IDA
IDA: 通过直接分析推断
11461150 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

vesicle-fusing ATPase

N-ethylmaleimide-sensitive factor

N-ethylmaleimide-sensitive fusion protein

NEM-sensitive fusion protein

vesicular-fusion protein NSF

Nsf 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Nsf Q9QUL6 Gria2 Rattus norvegicus P19491
Y2H
9697854
种属内
Nsf Q9QUL6 Gria2 Rattus norvegicus P19491
Pull Down
9697854
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-107353 Gadopentetic acid 99.89% 否
HY-160971 Ribonucleic Acid, Transfer from Brewing yeast Inhibitor ≥99.0% 否
HY-P1399A Pep2m, myristoylated TFA Inhibitor 99.77% 否
HY-P4114 TAT-NSF700scr 95.17% 否
HY-P1399 Pep2m, myristoylated Inhibitor / 否
HY-P4110 TAT-NSF222 Fusion Peptide Inhibitor / 否
HY-RS09591 NSF Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nsf NCBI NCBI:4905
Canis familiaris Nsf NCBI NCBI:490921
Macaca fascicularis Nsf NCBI NCBI:101866905
Mus musculus Nsf NCBI NCBI:18195
Susscrofa domestica Nsf NCBI
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