SAV1 - salvador family WW domain containing protein 1 Gene

中文名称：含萨尔瓦多家族 WW 结构域的蛋白 1

种属: Homo sapiens

同用名: SAV; WW45; WWP4

关于 SAV1

功能概要

含有 WW 结构域的蛋白质存在于所有真核生物中，并且在调节多种细胞功能 (例如蛋白质降解、转录和 RNA 剪接) 中发挥重要作用。该基因编码的蛋白质具有两个 WW 结构域、一个 SARAH 结构域和一个卷曲螺旋区域，在成人组织中普遍表达。该蛋白与 MST1 (哺乳动物不育 20 样激酶 1) 结合并促进 MST1 诱导的细胞凋亡。它也被证明可以与 HAX1 (造血细胞特异性蛋白 1 (HS1) 相关蛋白 X-1) 结合并减弱 HAX1 的抗凋亡作用。对人类和小鼠的研究表明，该基因具有肿瘤抑制因子的作用。[RefSeq 提供，2012 年 8 月]

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced Apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor. [provided by RefSeq, Aug 2012]