RNF6 - ring finger protein 6 Gene

中文名称：无名指蛋白 6

种属: Homo sapiens

基因 ID: 6049 | 基因类型: protein coding

关于 RNF6

Cytogenetic location: 13q12.13 Genomic coordinates (GRCh38): 13:26,132,115-26,223,085 (from NCBI)

This gene has 7 transcripts (splice variants), 202 orthologues, 3 paralogues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 18.5), brain (RPKM 11.7) and 25 other tissues.

功能概要

该基因编码的蛋白质包含一个 RING-H2 手指基序。在食管鳞状细胞癌 (ESCC) 中检测到该基因的缺失和突变，表明该蛋白可能是一种潜在的肿瘤抑制因子。小鼠对应物的研究表明这种蛋白质在控制生发分化的转录调节中发挥作用。观察到编码相同蛋白质的多个选择性剪接的转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed. [provided by RefSeq, Jul 2008]

RNF6 基因产物(4)

mRNA	Protein	Name
NM_005977.4	NP_005968.1	E3 ubiquitin-protein ligase RNF6 isoform 1
NM_183043.3	NP_898864.1	E3 ubiquitin-protein ligase RNF6 isoform 1
NM_183044.3	NP_898865.1	E3 ubiquitin-protein ligase RNF6 isoform 1
NM_183045.1	NP_898866.1	E3 ubiquitin-protein ligase RNF6 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables nuclear androgen receptor binding	IPI IPI: 通过物理相互作用推断	19345326	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	19345326	GOA
enables ubiquitin-protein transferase activity	IMP IMP: 通过突变表型推断	19345326	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of DNA-templated transcription	IMP IMP: 通过突变表型推断	19345326	GOA
involved in protein K27-linked ubiquitination	IDA IDA: 通过直接分析推断	19345326	GOA
involved in protein K6-linked ubiquitination	IDA IDA: 通过直接分析推断	19345326	GOA
involved in regulation of DNA-templated transcription	IMP IMP: 通过突变表型推断	19345326	GOA
involved in regulation of androgen receptor signaling pathway	IMP IMP: 通过突变表型推断	19345326	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	19345326	GOA
located in nucleus	IDA IDA: 通过直接分析推断	19345326	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RNF6 蛋白结构

zf-RING_2

0
200
400
600
685 a.a.

蛋白主名

其他名称

E3 ubiquitin-protein ligase RNF6

RING-H2 protein RNF-6

RNF6 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	RNF6	Q9Y252	AR	Homo sapiens	P10275	Confocal	19345326
种属内	RNF6	Q9Y252	AR	Homo sapiens	P10275	CH-IP	19345326
种属内	RNF6	Q9Y252	AR	Homo sapiens	P10275	Anti Bait CoIP	19345326

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Esophageal Cancer

Esophageal Carcinoma	Carcinoma Of Esophagus
Esophageal Squamous Cell Carcinoma, Somatic	Esophageal Carcinoma, Somatic
Esophagus Cancer	Gastric Cardia Adenocarcinoma
Esophageal Neoplasms	Esophageal Cancer, Somatic
Cancer Of Esophagus	Cancer Of Oesophagus
Carcinoma Of Oesophagus	Ca Lower Third Oesophagus
Ca Middle Third Oesophagus	Malignant Neoplasm Of Distal Third Of Esophagus
Malignant Neoplasm Of Lower Third Of Oesophagus	Malignant Neoplasm Of Middle Third Of Oesophagus
Malignant Neoplasm Of Proximal Third Of Esophagus	Malignant Neoplasm Of Upper Third Esophagus
Malignant Tumor Of Abdominal Esophagus	Malignant Tumor Of Distal Third Of Esophagus
Malignant Tumor Of Proximal Third Of Esophagus	Malignant Tumor Of The Middle Third Of The Esophagus
ESCR	Aerodigestive Tract Cancer
Escc	Esophageal Squamous Cell Carcinoma
Cancer, Esophageal	Malignant Neoplasm Of Esophagus
Squamous Cell Carcinoma Of Esophagus	Malignant Neoplasm Of Middle Third Of Esophagus

Esophagus Squamous Cell Carcinoma

Esophageal Squamous Cell Carcinoma	Oesophagus Squamous Cell Carcinoma
Scc Of Esophagus	Scc Of Oesophagus
Squamous Cell Carcinoma Of The Esophagus	Escc
Esophageal Epidermoid Carcinoma	Squamous Cell Esophageal Cancer
Squamous Cell Carcinoma Of Esophagus

Squamous Cell Carcinoma

Epidermoid Carcinoma	Squamous Cell Cancer
Carcinoma, Squamous Cell	Squamous Cell Skin Cancer
Malignant Squamous Cell Tumor	Squamous Carcinoma
Squamous Cell Epithelioma	Carcinoma Squamous Cell
Neoplasms, Squamous Cell	Squamous Cell Carcinoma - Category
Malignant Squamous Cell Neoplasm	Squamous Cell Carcinoma Of Skin

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12095	RNF6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	RNF6	VGNC	VGNC:34071
Felis catus	RNF6	VGNC	VGNC:64706
Canis familiaris	RNF6	VGNC	VGNC:45674
Macaca mulatta	RNF6	VGNC	VGNC:82225
Mus musculus	RNF6	MGD	MGI:1921382
Rattus norvegicus	RNF6	RGD	RGD:1306092

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

RNF6 - ring finger protein 6 Gene

关于 RNF6

功能概要

RNF6 基因产物(4)

RNF6 蛋白结构

RNF6 蛋白互作信息

关联疾病

直系同源

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RNF6 - ring finger protein 6 Gene

关于 RNF6

功能概要

RNF6 基因产物(4)

RNF6 蛋白结构

RNF6 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z