RNH1 - ribonuclease/angiogenin inhibitor 1 Gene

中文名称：核糖核酸酶/血管生成素抑制因子 1

种属: Homo sapiens

同用名: RAI; RNH

关于 RNH1

功能概要

胎盘核糖核酸酶抑制剂 (PRI) 是蛋白质细胞质 RNase 抑制剂家族的成员，存在于许多组织中并与细胞内和细胞外 RNase 结合 (由 Lee 等人总结，1988 [PubMed 3219362]) 。除了控制细胞内 RNases，抑制剂可能在血管生成素 (MIM 105850) 的调节中发挥作用。 50,000 Da 的核糖核酸酶抑制剂可与核糖核酸酶结合并将其保持在潜伏状态。由于中性和碱性核糖核酸酶可能在真核细胞 RNA 的周转中起着关键作用，因此 RNH 可能对于控制 mRNA 周转至关重要；真核细胞与核糖核酸酶的相互作用在体内可能是可逆的。[OMIM 提供，2010 年 7 月]

Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM, Jul 2010]