Gsk3a - glycogen synthase kinase 3 alpha Gene

中文名称：糖原合酶激酶 3α

种属: Mus musculus

同用名: 2700086H06Rik

关于 Gsk3a

功能概要

该基因编码的蛋白可启动蛋白质丝氨酸/苏氨酸激酶活性和信号受体结合活性。参与多个过程，包括细胞表面受体信号通路； G蛋白偶联受体信号通路的正调控；和基因表达的调控。作用于多个过程的上游或内部，包括细胞对锂离子的反应；蛋白质磷酸化的正调节；和蛋白质磷酸化。预测位于微管中。预计在轴突中活跃；胞质溶胶；和核。以多种结构表达，包括中枢神经系统；颅骨;早孕;舌头;和上颚。该基因的人类直系同源物与肌萎缩侧索硬化症有关。与人 GSK3A（糖原合成酶激酶 3 α）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein serine/threonine kinase activity and signaling receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of G protein-coupled receptor signaling pathway; and regulation of gene expression. Acts upstream of or within several processes, including cellular response to lithium ion; positive regulation of protein phosphorylation; and protein phosphorylation. Predicted to be located in microtubule. Predicted to be active in axon; cytosol; and nucleus. Is expressed in several structures, including central nervous system; cranium; early conceptus; tongue; and upper jaw. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human GSK3A (glycogen synthase kinase 3 alpha). [provided by Alliance of Genome Resources, Apr 2022]