RPL10 - ribosomal protein L10 Gene

中文名称：核糖体蛋白 L10

种属: Homo sapiens

同用名: QM; L10; NOV; AUTSX5; DXS648; MRXS35; DXS648E

基因 ID: 6134 | 基因类型: protein coding

关于 RPL10

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:154,398,065-154,402,339 (from NCBI)

This gene has 16 transcripts (splice variants), 103 orthologues, 1 paralogue and is associated with 52 phenotypes. Ubiquitous expression in ovary (RPKM 795.4), lymph node (RPKM 396.3) and 25 other tissues.

功能概要

该基因编码的核糖体蛋白是 60S 核糖体亚基的一个组成部分。鸡体内的相关蛋白可与 c-Jun 结合，抑制 c-Jun 介导的转录激活。一些研究发现该基因变异与自闭症谱系障碍之间存在关联，但其他研究并未发现这种关系。该基因的多个假基因散布在整个基因组中。可变剪接导致多个转录本变体。[RefSeq 提供，2015 年 1 月]

This gene encodes a ribosomal protein that is a component of the 60S ribosome subunit. The related protein in chicken can bind to c-Jun and can repress c-Jun-mediated transcriptional activation. Some studies have detected an association between variation in this gene and autism spectrum disorders, though Others do not detect this relationship. There are multiple pseudogenes of this gene dispersed throughout the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

RPL10 基因产物(6)

mRNA	Protein	Name
NM_001256577.2	NP_001243506.2	60S ribosomal protein L10 isoform b
NM_001256580.2	NP_001243509.2	60S ribosomal protein L10 isoform c
NM_001303624.2	NP_001290553.1	60S ribosomal protein L10 isoform a
NM_001303625.1	NP_001290554.1	60S ribosomal protein L10 isoform a
NM_001303626.1	NP_001290555.1	60S ribosomal protein L10 isoform d
NM_006013.5	NP_006004.3	60S ribosomal protein L10 isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	10508860	GOA
enables structural constituent of ribosome	IDA IDA: 通过直接分析推断	9443083	GOA
enables structural constituent of ribosome	IMP IMP: 通过突变表型推断	26290468	GOA
enables translation regulator activity	IMP IMP: 通过突变表型推断	26290468	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in embryonic brain development	IMP IMP: 通过突变表型推断	25316788	GOA
involved in negative regulation of apoptotic process	IMP IMP: 通过突变表型推断	10508860	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	10508860	GOA
involved in regulation of translation	IMP IMP: 通过突变表型推断	26290468	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of cytosolic large ribosomal subunit	IDA IDA: 通过直接分析推断	9443083	GOA
located in cytosolic ribosome	IDA IDA: 通过直接分析推断	23636399	GOA
located in nucleus	IDA IDA: 通过直接分析推断	10508860	GOA
part of protein-containing complex	IDA IDA: 通过直接分析推断	10508860	GOA
colocalizes with smooth endoplasmic reticulum	IDA IDA: 通过直接分析推断	10508860	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RPL10 蛋白结构

Ribosomal_L16

0
100
200
214 a.a.

蛋白主名

其他名称

60S ribosomal protein L10

Wilms tumor-related protein

RPL10 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	RPL10	P27635	SRC	Homo sapiens	P12931	Anti Bait CoIP	16741966
种属内	RPL10	P27635	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
种属内	RPL10	P27635	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
种属内	RPL10	P27635	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Intellectual Developmental Disorder, X-Linked, Syndromic, 35

MRXS35	Mental Retardation, X-Linked, Syndromic, 35
Intellectual Developmental Disorder, X-Linked Syndromic 35	Syndromic X-Linked Mental Retardation 35
X-Linked Intellectual Disability-Cerebellar Hypoplasia-Spondylo-Epiphyseal Dysplasia Syndrome	X-Linked Microcephaly-Growth Retardation-Prognathism-Cryptorchidism Syndrome
Intellectual Developmental Disorder, X-Linked, Syndromic 35	Mental Retardation, X-Linked, Syndromic, Type 35

Autism X-Linked 5

Autism, Susceptibility To, X-Linked 5	AUTSX5
Autism, X-Linked 5	Autism, Susceptibility To, X-Linked, Type 5

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Tinea Nigra

Microsporosis Nigra	Infection By Cladosporium Werneckii
Keratomycosis Nigricans	Tinea Palmaris Nigra
Keratomycosis Nigricans Palmaris

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Oculoglandular Tularemia

Pervasive Developmental Disorder

Pervasive Development Disorder	Pervasive Developmental Disorders
Pervasive Child Development Disorders	Autistic Behavior
Autism Spectrum Disorders

Olecranon Bursitis

Bursitis Of Elbow	Bursitis Of Elbow Region
Capped Elbow	Elbow Bursitis
Miner'S Elbow	Miners' Elbow
Shoe Boil

Tinea Favosa

Favus

Tinea Barbae

Dermatophytosis Of Beard

Tinea Imbricata

Kerion Celsi	Trichophyton Infection
Tinea Imbricata, Susceptibility To	Susceptibility To Tinea Imbricata
Tinea Capitis Profunda	Trichophytia Profunda Barbae
Trichophytia Profunda Capitis	Tinea Capitis

Renpenning Syndrome 1

Renpenning Syndrome	Golabi-Ito-Hall Syndrome
Mrxs3	Mrxs8
X-Linked Intellectual Disability Due To Pqbp1 Mutations	RENS1
Sutherland-Haan X-Linked Mental Retardation Syndrome	Shs
Mrx55	X-Linked Intellectual Disability, Renpenning Type
Sutherland-Haan Syndrome	Mental Retardation, X-Linked, Renpenning Type
Mental Retardation, X-Linked, With Spastic Diplegia	Mental Retardation, X-Linked, Syndromic 3
Mental Retardation, X-Linked, Syndromic 8	Mental Retardation, X-Linked 55
Syndromic X-Linked Mental Retardation 8	X-Linked Mental Retardation Renpenning Type
X-Linked Mental Retardation With Spastic Diplegia	Sutherland-Haan X-Linked Intellectual Disability Syndrome
X-Linked Intellectual Disability With Spastic Diplegia	Hamel Cerebropalatocardiac Syndrome
Porteous Syndrome	X-Linked Intellectual Deficit Due To Pqbp1 Mutations
X-Linked Intellectual Deficit, Renpenning Type	X-Linked Intellectual Disability, Sutherland-Haan Type
Hamel Cerebro-Palato-Cardiac Syndrome	Renpenning Syndrome, Type 1

Tinea Manuum

Tinea Manus

Dermatophytosis Of Hand

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12160	RPL10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS12161	RPL10A Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	RPL10	RGD	RGD:621178
Mus musculus	RPL10	MGD	MGI:105943

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

RPL10 - ribosomal protein L10 Gene

关于 RPL10

功能概要

RPL10 基因产物(6)

RPL10 蛋白结构

RPL10 蛋白互作信息

关联疾病

直系同源

热门区域

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RPL10 - ribosomal protein L10 Gene

关于 RPL10

功能概要

RPL10 基因产物(6)

RPL10 蛋白结构

RPL10 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z