2. Gene
  3. RPN2 - ribophorin II Gene

RPN2 - ribophorin II Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核蛋白 II

种属: Homo sapiens

同用名: SWP1; RPNII; RIBIIR; RPN-II

基因 ID: 6185 | 基因类型: protein coding

关于 RPN2

Cytogenetic location: 20q11.23 Genomic coordinates (GRCh38): 20:37,179,330-37,241,619 (from NCBI)

This gene has 9 transcripts (splice variants) and 208 orthologues. Ubiquitous expression in thyroid (RPKM 122.3), placenta (RPKM 121.1) and 25 other tissues.

功能概要

该基因编码仅在粗面内质网中发现的 I 型整合膜蛋白。编码的蛋白质是 N-寡糖基转移酶复合物的一部分，该复合物将高甘露糖寡糖连接到新生多肽链的 Asn-X-Ser/Thr 共有基序中发现的天冬酰胺残基。这种蛋白质在序列上与酵母寡糖转移酶亚基 SWP1 相似。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2008 年 10 月]

This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein is similar in sequence to the yeast oligosaccharyl transferase subunit SWP1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

RPN2 基因产物(9)

mRNA Protein Name
NM_001135771.3 NP_001129243.1 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 2 precursor
NM_001324299.2 NP_001311228.1 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 3 precursor
NM_001324301.2 NP_001311230.1 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 4 precursor
NM_001324302.2 NP_001311231.1 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 5 precursor
NM_001324303.2 NP_001311232.1 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 6 precursor
NM_001324304.2 NP_001311233.1 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 7 precursor
NM_001324305.2 NP_001311234.1 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 8 precursor
NM_001324306.2 NP_001311235.1 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 9
NM_002951.5 NP_002942.2 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
24965446 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein N-linked glycosylation IDA
IDA: 通过直接分析推断
9642163 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of oligosaccharyltransferase complex IDA
IDA: 通过直接分析推断
9642163 GOA
part of oligosaccharyltransferase complex IPI
IPI: 通过物理相互作用推断
31831667 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RPN2 蛋白结构

Ribophorin_II

Ribophorin_II: Oligosaccharyltransferase subunit Ribophorin II (3 - 628)

  • 0
  • 100
  • 200
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  • 400
  • 500
  • 631 a.a.
蛋白主名 其他名称

dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit

重组 RPN2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76574 RPN2/Ribophorin II Protein, Human (HEK293, Fc) P04844-1/NP_002942.2 (M1-V540) ≥95%
HY-P76575 RPN2/Ribophorin II Protein, Human (HEK293, His) P04844/NP_002942.2 (L23-V540) ≥95%

关联疾病

疾病名称 别名
Encephalitozoonosis

Infection By Encephalitozoon
Microsporidiosis

Infection By Microspora

Microsporidiasis

Infection By Microsporea

Infection By Microsporida

Intestinal Microsporidiosis

Microsporidia Infection

Infection By Microsporidia
Facial Clefting, Oblique, 1

Oculomaxillofacial Dysostosis

Oculomaxillofacial Dysplasia With Oblique Facial Clefts

OBLFC1

Oblique Facial Clefting 1

Tessier Number 4 Facial Cleft

Oblique Facial Cleft

Orbitofacial Cleft

Oblique Facial Clefts

Richieri Costa Gorlin Syndrome

Richieri-Costa-Gorlin Syndrome

Facial Clefting, Oblique, Type 1
Teebi Hypertelorism Syndrome 1

Teebi Hypertelorism Syndrome

Brachycephalofrontonasal Dysplasia

Hypertelorism, Teebi Type

TBHS1

Tbhs

Chromosome 22q11.2 Deletion Syndrome, Opitz Phenotype

Opitz Gbbb Syndrome Type Ii

Specc1l-Related Hypertelorism Syndrome

Opitz Gbbb Syndrome, Type Ii, Formerly

Gbbb2, Formerly

Opitz Bbbg Syndrome, Type Ii, Formerly

Bbbg2, Formerly

Opitz-G Syndrome, Type Ii, Formerly

Ogs2, Formerly

Opitz Bbb Syndrome, Type Ii, Formerly

Hypertelorism-Hypospadias Syndrome, Formerly

Hypertelorism With Esophageal Abnormality And Hypospadias, Formerly

Opitz Oculogenitolaryngeal Syndrome, Type Ii, Formerly

Opitz-Frias Syndrome, Formerly

Teebi Hypertelorism Syndrome-1

Craniofrontonasal Dysplasia, Teebi Type

Bbb Syndrome

Gbbb Syndrome

G Syndrome

Hypertelorism-Hypospadias Syndrome

Hypertelorism With Esophageal Abnormality And Hypospadias

Hypospadias-Dysphagia Syndrome

Ogs2

Opitz Bbbg Syndrome

Opitz-Frias Syndrome

Opitz Gbbb Syndrome, Autosomal Dominant

Opitz-G Syndrome, Type Ii

Opitz Oculogenitolaryngeal Syndrome, Type Ii

Opitz Gbbb Syndrome, Type Ii

Teebi Syndrome

Opitz-G Syndrome, Type 2

Opitz Gbbb Syndrome, X-Linked

Digeorge Syndrome
Autosomal Recessive Intellectual Developmental Disorder

Mental Retardation, Autosomal Recessive

Autosomal Recessive Mental Retardation

Autosomal Recessive Non-Syndromic Mental Retardation

Autosomal Recessive Non-Syndromic Intellectual Disability
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12211 RPN2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus RPN2 MGD MGI:98085
Felis catus RPN2 VGNC VGNC:64742
Canis familiaris RPN2 VGNC VGNC:45722
Bos taurus RPN2 VGNC VGNC:34120
Rattus norvegicus RPN2 RGD RGD:62075
Macaca mulatta RPN2 VGNC VGNC:76925
Others RPN2 NCBI
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