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  3. RPS6KA2 - ribosomal protein S6 kinase A2 Gene

RPS6KA2 - ribosomal protein S6 kinase A2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核糖体蛋白 S6 激酶 A2

种属: Homo sapiens

同用名: RSK; HU-2; RSK3; p90RSK2; p90-RSK3; pp90RSK3; MAPKAPK1C; S6K-alpha; S6K-alpha2

基因 ID: 6196 | 基因类型: protein coding

关于 RPS6KA2

Cytogenetic location: 6q27 Genomic coordinates (GRCh38): 6:166,409,364-166,862,773 (from NCBI)

This gene has 13 transcripts (splice variants), 209 orthologues and 7 paralogues. Ubiquitous expression in thyroid (RPKM 23.1), lung (RPKM 22.2) and 24 other tissues.

功能概要

该基因编码丝氨酸/苏氨酸激酶 RSK (核糖体 S6 激酶) 家族的成员。该激酶包含两个不同的激酶催化结构域并磷酸化各种底物，包括丝裂原活化激酶 (MAPK) 信号通路的成员。这种蛋白质的活性与控制细胞生长和分化有关。编码不同亚型的替代剪接变体已被表征。[RefSeq 提供，2016 年 1 月]

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains two non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternative splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jan 2016]

RPS6KA2 基因产物(9)

mRNA Protein Name
NM_001318938.1 NP_001305867.1 ribosomal protein S6 kinase alpha-2 isoform e
NM_001006932.3 NP_001006933.3 ribosomal protein S6 kinase alpha-2 isoform b
NM_001318936.2 NP_001305865.2 ribosomal protein S6 kinase alpha-2 isoform c
NM_001318937.2 NP_001305866.1 ribosomal protein S6 kinase alpha-2 isoform d
XM_006715549.4 XP_006715612.1 ribosomal protein S6 kinase alpha-2 isoform X1
XM_047419233.1 XP_047275189.1 ribosomal protein S6 kinase alpha-2 isoform X2
XM_047419235.1 XP_047275191.1 ribosomal protein S6 kinase alpha-2 isoform X4
XM_047419234.1 XP_047275190.1 ribosomal protein S6 kinase alpha-2 isoform X3
NM_021135.6 NP_066958.2 ribosomal protein S6 kinase alpha-2 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16810323 GOA
enables protein serine/threonine/tyrosine kinase activity IDA
IDA: 通过直接分析推断
22797923 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of cell cycle IDA
IDA: 通过直接分析推断
16878154 GOA
involved in negative regulation of cell population proliferation IDA
IDA: 通过直接分析推断
16878154 GOA
involved in positive regulation of apoptotic process IDA
IDA: 通过直接分析推断
16878154 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
16878154 GOA
located in nucleus IDA
IDA: 通过直接分析推断
16878154 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RPS6KA2 蛋白结构

Pkinase

Pkinase: Protein kinase domain (59 - 318)

Pkinase_C

Pkinase_C: Protein kinase C terminal domain (341 - 381)

Pkinase

Pkinase: Protein kinase domain (415 - 672)

  • 0
  • 200
  • 400
  • 600
  • 733 a.a.
蛋白主名 其他名称

ribosomal protein S6 kinase alpha-2

MAP kinase-activated protein kinase 1c

MAPK-activated protein kinase 1c

mitogen-activated protein kinase-activated protein kinase 1C

ribosomal S6 kinase 3

ribosomal protein S6 kinase, 90kDa, polypeptide 2

RPS6KA2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra RPS6KA2 Q15349 CSNK2B Homo sapiens P67870
Pull Down
32707033
Intra RPS6KA2 Q15349 CSNK2B Homo sapiens P67870
Y2H
21988832
Intra RPS6KA2 Q15349 SCRIB Homo sapiens Q14160
Anti Tag CoIP
30126976
Intra RPS6KA2 Q15349 SCRIB Homo sapiens Q14160
Pull Down
30126976
Intra RPS6KA2 Q15349 PRKCE Homo sapiens Q02156
Anti Bait CoIP
16810323
Intra RPS6KA2 Q15349 MAPK1 Homo sapiens P28482
Y2H Array
32296183
Intra RPS6KA2 Q15349 MAPK1 Homo sapiens P28482
Y2H Prey Pooling
32296183
Intra RPS6KA2 Q15349 MAPK1 Homo sapiens P28482
Pull Down
32707033
Intra RPS6KA2 Q15349 MAPK1 Homo sapiens P28482
Anti Tag CoIP
25852190
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 RPS6KA2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76011 RSK3 Protein, Human (sf9, GST) Q15349-1 (M1-L733) ≥95%

关联疾病

疾病名称 别名
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Cancer Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Coffin-Lowry Syndrome

CLS

Mental Retardation With Osteocartilaginous Abnormalities

Coffin Syndrome 1

Coffin Syndrome

Dwarfism, Lean Spastic Type

Lean Spastic Dwarfism

Coffin Lowry Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12251 RPS6KA2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS12252 Rps6ka2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS12253 Rps6ka2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta RPS6KA2 VGNC VGNC:76928
Bos taurus RPS6KA2 VGNC VGNC:34141
Felis catus RPS6KA2 VGNC VGNC:64755
Rattus norvegicus RPS6KA2 RGD RGD:620676
Mus musculus RPS6KA2 MGD MGI:1342290
Canis familiaris RPS6KA2 VGNC VGNC:45739
Others RPS6KA2 NCBI
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