RPS15 - ribosomal protein S15 Gene

中文名称：核糖体蛋白 S15

种属: Homo sapiens

同用名: RIG; S15

基因 ID: 6209 | 基因类型: protein coding

关于 RPS15

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:1,438,396-1,440,495 (from NCBI)

This gene has 13 transcripts (splice variants), 239 orthologues and is associated with 1 phenotype. Ubiquitous expression in ovary (RPKM 257.5), spleen (RPKM 201.4) and 25 other tissues.

功能概要

核糖体是催化蛋白质合成的细胞器，由一个小的 40S 亚基和一个大的 60S 亚基组成。这些亚基一起由 4 种 RNA 和大约 80 种结构不同的蛋白质组成。该基因编码的核糖体蛋白是 40S 亚基的一个组成部分。该蛋白属于核糖体蛋白 S19P 家族。它位于细胞质中。已发现该基因在各种肿瘤中被激活，例如胰岛素瘤、食道癌和结肠癌。作为典型的编码核糖体蛋白的基因，该基因有多个经过处理的假基因分散在基因组中。可变剪接导致多个转录本变体。[RefSeq 提供，2015 年 4 月]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19P family of ribosomal proteins. It is located in the cytoplasm. This gene has been found to be activated in various tumors, such as insulinomas, esophageal cancers, and colon cancers. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

RPS15 基因产物(2)

mRNA	Protein	Name
NM_001018.5	NP_001009.1	40S ribosomal protein S15 isoform 2
NM_001308226.2	NP_001295155.1	40S ribosomal protein S15 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables MDM2/MDM4 family protein binding	IPI IPI: 通过物理相互作用推断	23874713	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	24725412	GOA
enables structural constituent of ribosome	IDA IDA: 通过直接分析推断	23636399	GOA
enables structural constituent of ribosome	IMP IMP: 通过突变表型推断	18697920	GOA
enables ubiquitin ligase inhibitor activity	IDA IDA: 通过直接分析推断	23874713	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of signal transduction by p53 class mediator	IDA IDA: 通过直接分析推断	23874713	GOA
involved in rRNA processing	IMP IMP: 通过突变表型推断	18697920	GOA
involved in ribosomal small subunit biogenesis	IMP IMP: 通过突变表型推断	18697920	GOA
involved in ribosomal small subunit export from nucleus	IMP IMP: 通过突变表型推断	16037817	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytosolic ribosome	IDA IDA: 通过直接分析推断	23636399	GOA
part of cytosolic small ribosomal subunit	IDA IDA: 通过直接分析推断	8706699	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

40S ribosomal protein S15

homolog of rat insulinoma

RPS15 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	RPS15	P62841	LRRK2	Homo sapiens	Q5S007	Confocal	24725412
种属内	RPS15	P62841	LRRK2	Homo sapiens	Q5S007	Anti Bait CoIP	24725412
种属内	RPS15	P62841	G2E3	Homo sapiens	Q7L622	Y2H Array	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

Insulinoma

Islet Cell Adenoma	Insulin-Producing Tumor Of Islet Cells
Adenoma Islet Cell	Islet Cell Tumor
Experimental Organism Islet Cell Adenoma Neoplasm

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

Richter'S Syndrome

Richter Syndrome

Richter Transformation

Shwachman-Diamond Syndrome 1

Shwachman-Diamond Syndrome	Shwachman Syndrome
Shwachman-Bodian-Diamond Syndrome	Sds
Pancreatic Insufficiency And Bone Marrow Dysfunction	Shwachman-Bodian Syndrome
SDS1	Lipomatosis Of Pancreas, Congenital
Congenital Lipomatosis Of Pancreas	Shwachman-Diamond Type Metaphyseal Dysplasia
Metaphyseal Chondrodysplasia, Shwachman Type	Shwachman-Diamond-Oski Syndrome

Dyskeratosis Congenita

Dyskeratosis Congenita Autosomal Dominant	Dc
Dkc	Zinsser-Engman-Cole Syndrome
Dyskeratosis Congenita, Autosomal Dominant	Autosomal Dominant Dyskeratosis Congenita
Dkca	Dyskeratosis Congenita Scoggins Type
Zinsser-Cole-Engman Syndrome	X-Linked Dyskeratosis Congenita
Hoyeraal-Hreidarsson Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12225	RPS15 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS12226	RPS15A Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	RPS15	VGNC	VGNC:34131
Canis familiaris	RPS15	VGNC	VGNC:45731
Mus musculus	RPS15	MGD	MGI:98117
Rattus norvegicus	RPS15	RGD	RGD:62026

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

RPS15 - ribosomal protein S15 Gene

关于 RPS15

功能概要

RPS15 基因产物(2)

RPS15 蛋白互作信息

关联疾病

直系同源

热门区域

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RPS15 - ribosomal protein S15 Gene

关于 RPS15

功能概要

RPS15 基因产物(2)

RPS15 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z