RRM2 - ribonucleotide reductase regulatory subunit M2 Gene

中文名称：核糖核苷酸还原酶调节亚基 M2

种属: Homo sapiens

同用名: R2; RR2; RR2M; C2orf48

基因 ID: 6241 | 基因类型: protein coding

关于 RRM2

Cytogenetic location: 2p25.1 Genomic coordinates (GRCh38): 2:10,122,568-10,211,010 (from NCBI)

This gene has 17 transcripts (splice variants), 258 orthologues and 1 paralogue. Biased expression in bone marrow (RPKM 28.1), lymph node (RPKM 20.5) and 13 other tissues.

功能概要

该基因编码核糖核苷酸还原酶的两个不同亚基之一。该还原酶催化从核糖核苷酸形成脱氧核糖核苷酸。编码蛋白 (M2) 的合成以细胞周期依赖性方式进行调节。该基因的转录可以从替代启动子开始，这会产生两种 N 末端长度不同的亚型。已在 1 号和 X 号染色体上鉴定出相关的假基因。[RefSeq 提供，2009 年 9 月]

This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009]

RRM2 基因产物(2)

mRNA	Protein	Name
NM_001034.4	NP_001025.1	ribonucleoside-diphosphate reductase subunit M2 isoform 2
NM_001165931.1	NP_001159403.1	ribonucleoside-diphosphate reductase subunit M2 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	17726094	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in 2'-deoxyribonucleotide biosynthetic process	IDA IDA: 通过直接分析推断	16376858	GOA
involved in positive regulation of G1/S transition of mitotic cell cycle	IDA IDA: 通过直接分析推断	24253041	GOA
involved in ribonucleoside diphosphate metabolic process	IDA IDA: 通过直接分析推断	16376858	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytosol	IDA IDA: 通过直接分析推断	18997010	GOA
part of ribonucleoside-diphosphate reductase complex	IPI IPI: 通过物理相互作用推断	22632967	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RRM2 蛋白结构

Ribonuc_red_sm

0
100
200
300
389 a.a.

蛋白主名

其他名称

ribonucleoside-diphosphate reductase subunit M2

ribonucleotide reductase M2 polypeptide

RRM2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	RRM2	P31350	CCNF	Homo sapiens	P41002	Anti Tag CoIP	22632967
种属内	RRM2	P31350	CCNF	Homo sapiens	P41002	Confocal	22632967
种属内	RRM2	P31350	RRM1	Homo sapiens	P23921	Anti Tag CoIP	22632967
种属内	RRM2	P31350	FZR1	Homo sapiens	Q9UM11	Pull Down	22632967
种属内	RRM2	P31350	FZR1	Homo sapiens	Q9UM11	Anti Tag CoIP	22632967
种属内	RRM2	P31350	FZR1	Homo sapiens	Q9UM11	Anti Tag CoIP	33961781

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 RRM2 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71267	RRM2 Protein, Human (HEK293, His)	P31350-1 (M1-F389)	≥95%

关联疾病

疾病名称

别名

Diamond-Blackfan Anemia 20

DBA20

Rps15a-Related Diamond-Blackfan Anemia

Choriocarcinoma

Chorioepithelioma

Breast Disease

Breast Diseases

Syndromic X-Linked Intellectual Disability 94

Mrx94	Mrxs29
Syndromic X-Linked Intellectual Disability Due To Gria3 Anomalies	Syndromic X-Linked Mental Retardation 29
Syndromic X-Linked Mental Retardation Wu Type

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Oral Cavity Cancer

Malignant Neoplasm Of Floor Of Mouth	Oral Cavity Carcinoma
Malignant Neoplasm Of Mouth

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Tongue Disease

Abnormality Of The Tongue	Tongue Diseases
Tongue Disorders	Disorder Of Tongue
Glossopathy	Unspecified Condition Of The Tongue

Oral Squamous Cell Carcinoma

Mouth Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Mouth

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	是否罕见病
HY-B2116	Osalmid	Inhibitor	99.80%	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-153898	rTRD01	Inhibitor	≥97.0%	否
HY-112358	GW8510	Inhibitor	99.64%	否
HY-153736	NSC 194308		98.40%	否
HY-RS12286	RRM2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS12287	RRM2B Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	RRM2	VGNC	VGNC:103859
Mus musculus	RRM2	MGD	MGI:98181
Felis catus	RRM2	VGNC	VGNC:81213
Bos taurus	RRM2	VGNC	VGNC:34165
Canis familiaris	RRM2	VGNC	VGNC:45761
Rattus norvegicus	RRM2	RGD	RGD:1598310
Others	RRM2	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

RRM2 - ribonucleotide reductase regulatory subunit M2 Gene

关于 RRM2

功能概要

RRM2 基因产物(2)

RRM2 蛋白结构

RRM2 蛋白互作信息

重组 RRM2 蛋白

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

RRM2 - ribonucleotide reductase regulatory subunit M2 Gene

关于 RRM2

功能概要

RRM2 基因产物(2)

RRM2 蛋白结构

RRM2 蛋白互作信息

重组 RRM2 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z