CCNF - cyclin F Gene

中文名称：细胞周期素 F

种属: Homo sapiens

同用名: FBX1; FBXO1; FTDALS5

基因 ID: 899 | 基因类型: protein coding

关于 CCNF

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:2,429,447-2,458,854 (from NCBI)

This gene has 5 transcripts (splice variants), 222 orthologues, 18 paralogues and is associated with 2 phenotypes. Broad expression in lymph node (RPKM 3.5), bone marrow (RPKM 2.7) and 24 other tissues.

功能概要

该基因编码细胞周期蛋白家族的一个成员。细胞周期蛋白通过结合和激活细胞周期蛋白依赖性蛋白激酶的能力，成为细胞周期转换的重要调节剂。该成员也属于 F-box 蛋白家族，其特征是大约有 40 个氨基酸基序，即 F-box。 F-box 蛋白构成称为 SCF (SKP1-cullin-F-box) 的泛素蛋白连接酶复合物的四个亚基之一，其在磷酸化依赖性泛素化中发挥作用。 F-box 蛋白分为 3 类：包含 WD-40 结构域的 Fbws、包含富含亮氨酸重复序列的 Fbls 和包含不同蛋白质-蛋白质相互作用模块或无可识别基序的 Fbxs。由该基因编码的蛋白质属于 Fbxs 类，它是最早发现 F-box 基序的蛋白质之一。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein Ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified. [provided by RefSeq, Jul 2008]

CCNF 基因产物(2)

mRNA	Protein	Name
NM_001323538.2	NP_001310467.1	cyclin-F isoform 2
NM_001761.3	NP_001752.2	cyclin-F isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables anaphase-promoting complex binding	IDA IDA: 通过直接分析推断	25557911	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	20596027	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: 通过直接分析推断	20596027	GOA
involved in negative regulation of centrosome duplication	IDA IDA: 通过直接分析推断	20596027	GOA
involved in protein ubiquitination	IDA IDA: 通过直接分析推断	20596027	GOA
involved in regulation of cell cycle	IDA IDA: 通过直接分析推断	25557911	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of SCF ubiquitin ligase complex	IDA IDA: 通过直接分析推断	20596027	GOA
located in centriole	IDA IDA: 通过直接分析推断	20596027	GOA
located in nucleus	IDA IDA: 通过直接分析推断	20596027	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CCNF 蛋白结构

F-box

Cyclin_N

Cyclin_C

0
200
400
600
786 a.a.

蛋白主名

其他名称

cyclin-F

F-box only protein 1

CCNF 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	CCNF	P41002	CCP110	Homo sapiens	O43303	IPAC	20596027
Intra	CCNF	P41002	CCP110	Homo sapiens	O43303	Anti Tag CoIP	22632967
Intra	CCNF	P41002	CCP110	Homo sapiens	O43303	Anti Bait CoIP	20596027
Intra	CCNF	P41002	CCP110	Homo sapiens	O43303	Anti Tag CoIP	20596027
Intra	CCNF	P41002	RRM2	Homo sapiens	P31350	Pull Down	22632967
Intra	CCNF	P41002	RRM2	Homo sapiens	P31350	Anti Tag CoIP	22632967
Intra	CCNF	P41002	RRM2	Homo sapiens	P31350	Anti Bait CoIP	22632967
Intra	CCNF	P41002	SKP1	Homo sapiens	P63208	Anti Bait CoIP	22632967
Intra	CCNF	P41002	SKP1	Homo sapiens	P63208	Anti Tag CoIP	22632967
Intra	CCNF	P41002	SKP1	Homo sapiens	P63208-1	Anti Bait CoIP	20596027
Intra	CCNF	P41002	SKP1	Homo sapiens	P63208-1	Anti Tag CoIP	20596027
Intra	CCNF	P41002	SKP1	Homo sapiens	P63208-1	IPAC	20596027
Intra	CCNF	P41002	CUL1	Homo sapiens	Q13616	IPAC	20596027
Intra	CCNF	P41002	CUL1	Homo sapiens	Q13616	Anti Tag CoIP	20596027
Intra	CCNF	P41002	CUL1	Homo sapiens	Q13616	Anti Tag CoIP	22632967

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 5

FTDALS5

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Frontotemporal Dementia

Pallidopontonigral Degeneration	Frontotemporal Lobar Degeneration
Semantic Dementia	FTD
Frontotemporal Lobe Dementia	Multiple System Tauopathy With Presenile Dementia
Dementia, Frontotemporal	Frontotemporal Dementia With Parkinsonism
Mstd	Frontotemporal Lobar Degeneration With Tau Inclusions
Ftld With Tau Inclusions	Dementia, Frontotemporal, With Parkinsonism
Fldem	Ftdp17
Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex	Ddpac
Wilhelmsen-Lynch Disease	Wld
Ppnd	Dementia, Frontotemporal, With Or Without Parkinsonism
Semantic Primary Progressive Aphasia	Semantic Variant Ppa
Wilhemsen-Lynch Disease	Frontotemporal Dementia-Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17	Ftd-Als
Ftld	Pick Complex
Pick Disease Of The Brain	Frontotemporal Dementia With Parkinsonism-17
Grn-Related Frontotemporal Dementia	Frontotemporal Dementia With Motor Neuron Disease
Dementia In Fronto-Temporal Lobar Degeneration	Ftd - [Frontotemporal Dementia]
Temple Dementia	Frontal Lobe Dementia

Dementia

Dementias	Presenile Dementia
Alzheimer Type Dementia	Alzheimer Sclerosis
Alzheimer Disease Dementia	Alzheimer Dementia
Primary Degenerative Alzheimer Type Dementia	End Stage Alzheimer'S Dementia
Alzheimer'S Type Atypical Dementia	Alzheimer Type Presenile Dementia
Early Onset Alzheimer Dementia	Dementia In Alzheimer Disease Type 2
Dementia In Alzheimer Disease With Early Onset	Early Onset Alzheimer Type Dementia, Uncomplicated
Primary Degenerative Alzheimer Type Dementia, Early Onset	Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated
Alzheimer Disease Dementia With Early Onset	Presenile Sclerosis
Presenile Brain Sclerosis	Presenile Alzheimer Brain Sclerosis
Late Onset Alzheimer Dementia	Dementia In Alzheimer Disease Type 1
Dementia In Alzheimer Disease With Late Onset	Primary Degenerative Alzheimer Type Dementia, Late Onset
Sdat - [Senile Dementia, Alzheimer Type]	Alzheimer Disease Dementia With Late Onset
Late Onset Alzheimer Brain Sclerosis	Senile Alzheimer Brain Disease
Senile Alzheimer Brain Sclerosis	Senile Primary Degenerative Alzheimer Type Dementia
Senile Dementia Of The Alzheimer Type	Arteriosclerotic Dementia
Strategic-Infarct Dementia	Post Stroke Dementia
Vascular Cognitive Impairment	Vascular Dementia
Dementia Of The Lewy Body Type	Dementia With Lewy Bodies
Sdlt - [Senile Dementia Of The Lewy Body Type]	Senile Dementia Of The Lewy Body Type
Alcohol-Related Dementia	Alcoholic Dementia Nos
Alcohol-Induced Dementia	Alcoholic Brain Syndrome
Chronic Alcoholic Brain Syndrome	Alcohol Dementia
Late Onset Alcoholic Psychosis	Residual And Late-Onset Alcohol-Induced Psychotic Disorder
Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder	Late-Onset Psychoactive Substance-Induced Psychotic Disorder
Inhalant Dementia	Volatile Solvents Dementia
Dementia In Paralysis Agitans	Pdd - [Parkinson Disease Dementia]
Dementia Syndrome Of Parkinson Disease	Dementia In Parkinson Disease
Parkinson Related Dementia	Dementia In Huntington Chorea
Hiv - [Human Immunodeficiency Virus] Dementia	Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex
Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex	Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex
Aids Related Dementia	Dementia Due To Niacin Deficiency

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 2

FTDALS2	Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-2
Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis, Type 2

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 3

FTDALS3	Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-3
Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis, Type 3

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 4

FTDALS4	Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-4
Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis, Type 4

Spondylometaphyseal Dysplasia, Axial

Axial Spondylometaphyseal Dysplasia	SMDAX
Axial Smd	Smd Axial
Smd, Axial	Spondylometaphyseal Dysplasia Axial Type
Dysplasia, Spondylometaphyseal, Axial

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1

FTDALS1	Frontotemporal Dementia And/Or Motor Neuron Disease
Ftdmnd	Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia
Alsftd	Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1	Frontotemporal Dementia With Motor Neuron Disease
Ftdals	Ftd-Als
Ftd-Mnd	Frontotemporal Dementia With Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1	Amyotrophic Lateral Sclerosis/Frontotemporal Dementia
Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1
Frontotemporal Lobar Degeneration	Grn-Related Frontotemporal Dementia

Mitochondrial Complex Iv Deficiency, Nuclear Type 1

Cytochrome C Oxidase Deficiency	Mitochondrial Complex Iv Deficiency
Cox Deficiency	Cytochrome-C Oxidase Deficiency Disease
MC1DN4	Cytochrome-C Oxidase Deficiency
MC4DN1	Mitochondrial Complex I Deficiency, Nuclear Type 4
Complex 4 Mitochondrial Respiratory Chain Deficiency	Complex Iv Deficiency
Mitochondrial Complex 1 Deficiency, Nuclear Type 4	Nuclear Type Mitochondrial Complex I Deficiency 4
Deficiency Of Mitochondrial Respiratory Chain Complex4	MT-C4D
Complex Iv Mitochondrial Respiratory Chain Deficiency	Lethal Neonatal Cardiomyopathy Hypertrophic Due To Cytochrome C Oxidase Deficiency
Mitochondrial Complex Iv Deficiency, Nuclear, Type 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02129	CCNF Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	CCNF	VGNC	VGNC:26968
Mus musculus	CCNF	MGD	MGI:102551
Rattus norvegicus	CCNF	RGD	RGD:67401
Macaca mulatta	CCNF	VGNC	VGNC:70729
Felis catus	CCNF	VGNC	VGNC:60559
Canis familiaris	CCNF	VGNC	VGNC:38899

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CCNF - cyclin F Gene

关于 CCNF

功能概要

CCNF 基因产物(2)

CCNF 蛋白结构

CCNF 蛋白互作信息

关联疾病

直系同源

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CCNF - cyclin F Gene

关于 CCNF

功能概要

CCNF 基因产物(2)

CCNF 蛋白结构

CCNF 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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C

F

G

H

J

L

N

Q

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T

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