RYK - receptor like tyrosine kinase Gene

中文名称：酪氨酸激酶样受体

种属: Homo sapiens

同用名: JTK5; RYK1; JTK5A; D3S3195

关于 RYK

功能概要

由该基因编码的蛋白质是生长因子受体蛋白酪氨酸激酶家族的非典型成员，与其他成员的区别在于激活和核苷酸结合域中的许多保守残基。该基因产物属于一个亚家族，其成员似乎不受激活片段中磷酸化的调节。有人提出，通过招募具有信号能力的辅助蛋白来调节生物活性可能是通过一种尚未表征的机制发生的。编码的蛋白质具有富含亮氨酸的细胞外结构域和 WIF 型 Wnt 结合区、单个跨膜结构域和细胞内酪氨酸激酶结构域。这种蛋白质参与刺激 Wnt 信号通路，例如轴突寻路的调节。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2012 年 2 月]

The protein encoded by this gene is an atypical member of the family of growth factor receptor Protein Tyrosine Kinases, differing from Other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]