S100A5 - S100 calcium binding protein A5 Gene

中文名称：S100 钙结合蛋白 A5

种属: Homo sapiens

同用名: S100D

关于 S100A5

功能概要

由该基因编码的蛋白质是包含 2 个 EF 手钙结合基序的 S100 蛋白质家族的成员。 S100 蛋白定位于多种细胞的细胞质和/或细胞核，并参与许多细胞过程的调节，例如细胞周期进程和分化。 S100 基因包括至少 13 个成员，它们成簇地位于染色体 1q21 上。这种蛋白质的 Ca2+ 亲和力比在相同条件下研究的其他 S100 蛋白质高 20 到 100 倍。该蛋白质还结合 Zn2+ 和 Cu2+，而 Cu2+ 强烈削弱 Ca2+ 的结合。这种蛋白质在成人大脑的非常有限的区域中表达。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has a Ca2+ affinity 20- to 100-fold higher than the Other S100 proteins studied under identical conditions. This protein also binds Zn2+ and Cu2+, and Cu2+ strongly which impairs the binding of Ca2+. This protein is expressed in very restricted regions of the adult brain. [provided by RefSeq, Jul 2008]