S100A9 - S100 calcium binding protein A9 Gene

中文名称：S100 钙结合蛋白 A9

种属: Homo sapiens

同用名: MIF; NIF; P14; CAGB; CFAG; CGLB; L1AG; LIAG; MRP14; 60B8AG; MAC387; S100-A9

基因 ID: 6280 | 基因类型: protein coding

关于 S100A9

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,357,854-153,361,023 (from NCBI)

This gene has 1 transcript (splice variant), 344 orthologues and 21 paralogues. Biased expression in bone marrow (RPKM 7440.5), esophagus (RPKM 5956.4) and 1 other tissue.

功能概要

由该基因编码的蛋白质是包含 2 个 EF 手钙结合基序的 S100 蛋白质家族的成员。 S100 蛋白定位于多种细胞的细胞质和/或细胞核，并参与许多细胞过程的调节，例如细胞周期进程和分化。 S100 基因包括至少 13 个成员，它们成簇地位于染色体 1q21 上。这种蛋白质可能在抑制酪蛋白激酶方面起作用，并且这种蛋白质的表达改变与囊性纤维化疾病有关。这种抗菌蛋白具有抗真菌和抗菌活性。[RefSeq 提供，2014 年 11 月]

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of Casein Kinase and altered expression of this protein is associated with the disease cystic fibrosis. This antimicrobial protein exhibits Antifungal and Antibacterial activity. [provided by RefSeq, Nov 2014]

S100A9 基因产物(1)

mRNA	Protein	Name
NM_002965.4	NP_002956.1	protein S100-A9

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	9867828	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: 通过直接分析推断	19935772	GOA
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: 通过直接分析推断	12874352	GOA
involved in autophagy	IDA IDA: 通过直接分析推断	19935772	GOA
involved in leukocyte migration involved in inflammatory response	IDA IDA: 通过直接分析推断	12626582	GOA
involved in modulation of process of another organism	IDA IDA: 通过直接分析推断	12874352	GOA
involved in neutrophil aggregation	IDA IDA: 通过直接分析推断	12626582	GOA
involved in neutrophil chemotaxis	IDA IDA: 通过直接分析推断	12626582	GOA
involved in peptidyl-cysteine S-trans-nitrosylation	IDA IDA: 通过直接分析推断	25417112	GOA
involved in positive regulation of inflammatory response	IDA IDA: 通过直接分析推断	12626582	GOA
involved in positive regulation of intrinsic apoptotic signaling pathway	IDA IDA: 通过直接分析推断	19935772	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of S100A9 complex	IPI IPI: 通过物理相互作用推断	11851337	GOA
part of calprotectin complex	IPI IPI: 通过物理相互作用推断	25597447	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	12874352	GOA
located in extracellular space	IDA IDA: 通过直接分析推断	21805676	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

S100A9 蛋白结构

S_100

0
100
114 a.a.

蛋白主名

其他名称

protein S100-A9

MRP-14

S100A9 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	S100A9	P06702	MAGEA6	Homo sapiens	P43360	Validated Y2H	32296183
种属内	S100A9	P06702	MAGEA6	Homo sapiens	P43360	Y2H Array	32296183
种属内	S100A9	P06702	MAGEA6	Homo sapiens	P43360	Y2H Prey Pooling	32296183
种属内	S100A9	P06702	S100A8	Homo sapiens	P05109	Y2H	9867828
种属内	S100A9	P06702	S100A8	Homo sapiens	P05109	Anti Tag CoIP	25417112
种属内	S100A9	P06702	S100A8	Homo sapiens	P05109	Y2H Pooling	20936779
种属内	S100A9	P06702	S100A8	Homo sapiens	P05109	Anti Bait CoIP	25417112
种属内	S100A9	P06702	S100B	Homo sapiens	P04271	Y2H Prey Pooling	32296183
种属内	S100A9	P06702	S100B	Homo sapiens	P04271	Y2H Array	32296183
种属内	S100A9	P06702	MAGEA3	Homo sapiens	P43357	Validated Y2H	32296183
种属内	S100A9	P06702	MAGEA3	Homo sapiens	P43357	Y2H Array	32296183
种属内	S100A9	P06702	MAGEA3	Homo sapiens	P43357	Y2H Prey Pooling	32296183
种属内	S100A9	P06702	ARRB2	Homo sapiens	P32121	Anti Tag CoIP	17620599
种属内	S100A9	P06702	MAGEA1	Homo sapiens	P43355	Validated Y2H	32296183
种属内	S100A9	P06702	MAGEA1	Homo sapiens	P43355	Y2H Array	32296183
种属内	S100A9	P06702	MAGEA1	Homo sapiens	P43355	Y2H Prey Pooling	32296183
种属内	S100A9	P06702	ARRB1	Homo sapiens	P49407	Anti Tag CoIP	17620599

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 S100A9 蛋白

目录号	产品名	蛋白编号	纯度
HY-P70532	S100A9 Protein, Human	P06702 (T2-P114)	≥95%
HY-P71076	S100A8-S100A9 Heterodimer Protein, Human (His, solution)	P05109 (M1-E93) (S100A8) & P06702 (T2-P114) (S100A9)	≥95%
HY-P76587	S100A9 Protein, Human (sf9, His)	P06702 (M1-P114)	≥95%
HY-P70532A	S100A9 Protein, Human (His)	P06702 (T2-P114)	≥95%

S100A9 抗体

目录号	产品名	应用	反应物种
HY-P83734	S100A9 Antibody(YA3464)	WB, IHC-P, ICC/IF	Human

关联疾病

疾病名称

别名

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Juvenile Rheumatoid Arthritis

Juvenile Idiopathic Arthritis	Juvenile Chronic Polyarthritis
Monarticular Juvenile Rheumatoid Arthritis	Pauciarticular Juvenile Arthritis
Still'S Disease	Systemic Juvenile Rheumatoid Arthritis
Juvenile Chronic Arthritis	Acute Juvenile Rheumatoid Arthritis
Pauciarticular Onset Juvenile Chronic Arthritis	Arthritis, Juvenile Rheumatoid
Jia	Jra
Juvenile Ra	Arthritis Juvenile Rheumatoid
Stills Disease	Juvenile Arthritis
Acute Polyarticular Juvenile Rheumatoid Arthritis	Pauciarticular Juvenile Rheumatoid Arthritis
Rheumatoid Arthritis, Systemic Juvenile

Crohn'S Disease

Crohn Disease	Pediatric Crohn'S Disease
Regional Enteritis	Crohn'S Disease Of Large Bowel
Granulomatous Colitis	Enteritis, Granulomatous
Enteritis	Crohn'S Disease Of Colon
Colitis, Granulomatous	Crohn'S Enteritis
Enteritis, Regional	Ileitis
Adenoviral Enteritis	Acute Gastroenteropathy Due To Norwalk Agent
Viral Gastroenteritis Due To Norwalk Agent	Winter Vomiting
Epidemic Winter Vomiting Disease	Small Round Structured Virus Enteritis
Epidemic Vomiting Syndrome	Epidemic Vomiting
Epidemic Nausea	Epidemic Viral Gastroenteritis Due To Norwalk Virus
Noroviral Enteritis	Crohn Disease Nos
Crohns	Cd - [Crohn'S Disease]
Regional Enteritis Of Bowel	Crohn'S Regional Enteritis
Cobble-Stone Appearance Of Intestine	Intestinal Ulcer And Erosion Due To Crohn Disease
Granulomatous Enteritis

Erythema Elevatum Diutinum

Fibroma

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Psoriasis

Pouchitis

Appendicitis

Acute Appendicitis	Acute Appendicitis With Generalized Peritonitis
Acute Appendicitis Nos	Acute Appendicitis With Peritoneal Abscess
Appendiceal Inflammation	Appendicitis, Unqualified
Acute Appendix Inflammation	Acute Appendicitis With Diffuse Peritonitis Following Rupture Or Perforation
Acute Appendicitis With Free Peritonitis	Acute Appendicitis With Free Perforation To The Abdominal Cavity
Perforated Appendix With Generalised Peritonitis	Appendicitis With Perforation And Free Pus In The Peritoneal Cavity
Perforated Appendix With Localised Peritonitis	Acute Appendicitis With Contained Perforation To A Localised Abscess
Acute Appendicitis With Localised Peritonitis With Rupture Or Perforation	Acute Appendicitis With Localised Peritonitis Without Rupture Or Perforation
Acute Appendicitis With Perforation And Contained Peritonitis Into An Abscess	Appendicitis With Abscess
Appendicitis With Peritoneal Abscess	Ruptured Appendix Nos
Acute Appendicitis With No Perforation Or Abscess And No Visible Pus	Acute Appendicitis With No Specification If Perforated Or Not
Acute Appendicitis With Phlegmone

Renal Infectious Disease

Lupus Erythematosus

Lupus	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus, Systemic
Subacute Cutaneous Lupus	Le - [Lupus Erythematosus]

Vasculitis

Angiitis	Autoimmune Vasculitis
Systemic Vasculitis	Vasculitis, Autoimmune

Gout

Gouty Arthritis	Articular Gout
Gouty Arthropathy	Arthritis, Gouty
Arthritis Gouty	Idiopathic Gout
Idiopathic Gout, Unspecified Site	Gouty Bursitis
Uratic Arthritis	Gout Nos
Gouty	Gouty Diathesis

Lung Disease

Lung Diseases	Disorder Of Lung
Abnormality Of The Lung

Kawasaki Disease

Mucocutaneous Lymph Node Syndrome	Acute Febrile Mucocutaneous Lymph Node Syndrome
Kawasaki Syndrome	Kd
Infantile Polyarteritis	Kawasaki Disease, Susceptibility To
Acute Febrile Mcls	Kawasaki'S Disease
Mlns	KWD

Nodular Tenosynovitis

Synovioma, Benign	Benign Synovioma
Benign Tumor Of Synovium	Localized Giant Cell Tumor Of Tenosynovium
Giant Cell Tumor Of Tendon Sheath

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Diverticulitis

Multicentric Reticulohistiocytosis

Lipoid Dermatoarthritis

Giant Cell Histiocytomatosis

Sexual Sadism

Sadism

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Spondylarthropathy

Spondylarthropathies

Congenital Epulis

Gingival Neoplasms	Congenital Epulides
Congenital Gingival Cell Tumor	Congenital Granular Cell Tumor
Neumann Tumor

Sarcoidosis 1

Sarcoidosis	Boeck Sarcoid
Besnier-Boeck-Schaumann Disease	SS1
Sarcoidosis, Susceptibility To, 1	Lymphogranulomatosis
Hodgkin Disease	Boeck'S Disease
Boeck'S Sarcoid	Schaumann'S Disease Or Syndrome
Hutchinson-Boeck Disease Or Syndrome

Omsk Hemorrhagic Fever

Ohf	Hemorrhagic Fever, Omsk
Ohf - [Omsk Haemorrhagic Fever]	Spring-Fall Haemorrhagic Fever

Congenital Granular Cell Tumor

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Connective Tissue Disease

Connective Tissue Diseases	Connective Tissue Disorder
Abnormality Of Connective Tissue	Disorder Of Connective Tissue
Connective Tissue Disorders

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-10528	Tasquinimod	Modulator	99.94%	Phase 3
HY-100442	Paquinimod	Inhibitor	99.90%	Phase 2

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-10528S	Tasquinimod-d3	Modulator	99.34%	否
HY-100442S1	Paquinimod-d5-1	Inhibitor	98.19%	否
HY-RS12386	S100A9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-100442S	Paquinimod-d5	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	S100A9	RGD	RGD:620267
Mus musculus	S100A9	MGD	MGI:1338947
Bos taurus	S100A9	VGNC	VGNC:34247
Macaca mulatta	S100A9	VGNC	VGNC:76961
Felis catus	S100A9	VGNC	VGNC:64843
Canis familiaris	S100A9	NCBI	NCBI:490463
Macaca fascicularis	S100A9	NCBI	NCBI:102122456
Others	S100A9	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

S100A9 - S100 calcium binding protein A9 Gene

关于 S100A9

功能概要

S100A9 基因产物(1)

S100A9 蛋白结构

S100A9 蛋白互作信息

重组 S100A9 蛋白

S100A9 抗体

关联疾病

直系同源

热门区域

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S100A9 - S100 calcium binding protein A9 Gene

关于 S100A9

功能概要

S100A9 基因产物(1)

S100A9 蛋白结构

S100A9 蛋白互作信息

重组 S100A9 蛋白

S100A9 抗体

关联疾病

相关产品

直系同源

热门区域

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G

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