1. Gene
  2. CCL17 - C-C motif chemokine ligand 17 Gene

CCL17 - C-C motif chemokine ligand 17 Gene

中文名称:CC 基序趋化因子配体 17

种属: Homo sapiens

同用名: TARC; ABCD-2; SCYA17; A-152E5.3

基因 ID: 6361 | 基因类型: protein coding

关于 CCL17

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:57,396,093-57,416,063 (from NCBI)

This gene has 2 transcripts (splice variants), 96 orthologues and 25 paralogues. Biased expression in appendix (RPKM 2.1), lymph node (RPKM 1.4) and 13 other tissues.

功能概要

这种抗菌基因是聚集在 16 号染色体 q 臂上的几个 Cys-Cys (CC) 细胞因子基因之一。细胞因子是一个参与免疫调节和炎症过程的分泌蛋白家族。 CC 细胞因子是以两个相邻的半胱氨酸为特征的蛋白质。由该基因编码的细胞因子显示出对 T 淋巴细胞的趋化活性,但对单核细胞或粒细胞没有趋化活性。该基因的产物与趋化因子受体 CCR4CCR8 结合。这种趋化因子在胸腺 T 细胞发育以及成熟 T 细胞的运输和激活中起重要作用。[RefSeq 提供,2014 年 9 月]

This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. [provided by RefSeq, Sep 2014]

CCL17 基因产物(1)

mRNA Protein Name
NM_002987.3 NP_002978.1 C-C motif chemokine 17 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
28381538 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
IDA: 通过直接分析推断
12949249 GOA
involved in killing of cells of another organism IDA
IDA: 通过直接分析推断
12949249 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CCL17 蛋白结构

IL8

IL8: Small cytokines (intecrine/chemokine), interleukin-8 like (30 - 88)

  • 0
  • 94 a.a.
蛋白主名 其他名称

C-C motif chemokine 17

CC chemokine TARC

CCL17 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CCL17 Q92583 P13501-PRO_0000005175 Homo sapiens P13501-PRO_0000005175
Solution NMR
28381538
种属内
CCL17 Q92583 PF4 Homo sapiens P02776
SPR
28381538
种属内
CCL17 Q92583 CCL5 Homo sapiens P13501
Solution NMR
28381538
种属内
CCL17 Q92583 CCL5 Homo sapiens P13501
SPR
28381538
种属内
CCL17 Q92583 CCL5 Homo sapiens P13501
Filter Binding
28381538
种属内
CCL17 Q92583 CCL5 Homo sapiens P13501
PLA
28381538
种属内
CCL17 Q92583 CCR5 Homo sapiens P51681
FACS
28381538
种属内
CCL17 Q92583 CCL28 Homo sapiens Q9NRJ3
Filter Binding
28381538
种属内
CCL17 Q92583 CCL26 Homo sapiens Q9Y258
Filter Binding
28381538
种属内
CCL17 Q92583 CCR4 Homo sapiens P51679
FACS
28381538
种属内
CCL17 Q92583 CCL21 Homo sapiens O00585
Filter Binding
28381538
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CCL17 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7292 TARC/CCL17 Protein, Human Q92583 (A24-S94) ≥95%
HY-P7759 TARC/CCL17 Protein, Human (HEK293, His) Q92583 (A24-S94) ≥95%
HY-P74531 TARC/CCL17 Protein, Human (sf9, His) Q92583 (A24-S94) ≥95%
HY-P74532 TARC/CCL17 Protein, Human (sf9) Q92583 (A24-S94) ≥95%

关联疾病

疾病名称 别名
Eosinophilic Pneumonia

Pneumonia, Eosinophilic

Pulmonary Eosinophilia

Asthmatic Pulmonary Eosinophilia

Pneumonia Eosinophilic

Simple Pulmonary Eosinophilia

Eosinophilic Asthma

Paragonimiasis

Infection By Paragonimus

Lung Fluke Disease

Lung Fluke Infection

Pulmonary Paragonimiasis

Paragonimus Westermani Infection

Pulmonary Distomiasis

Parasitic Haemoptysis

Oriental Lung Fluke Disease

Endemic Haemoptysis

Paragonimosis

Pulmonary Distomatosis

Lung Fluke Disorder

Infestation By Paragonimus

Infection Due To Paragonimus Species

Infestation Due To Paragonimus Species

Oriental Lung Fluke Infestation

Endemic Oriental Haemoptysis

Dermatitis

Eczema

Skin Inflammation

Inflammatory Dermatosis

Mycosis Fungoides

Mycosis Fungoides Lymphoma

Alibert-Bazin Syndrome

Granuloma Fungoides

Classic Mycosis Fungoides

Mycosis Fungoides, Alibert-Bazin Type

Dermatitis, Atopic

Atopic Dermatitis

Atopic Eczema

Dermatitis, Atopic, Susceptibility To, 1

Atod

Eczema, Atopic

Dermatitis, Atopic 1

Allergic Dermatitis

Atopic Neurodermatitis

Besnier'S Prurigo

Dermatitis, Atopic, 1

Dermatitis Atopic

Eczema

Besnier Prurigo

Palladium Allergic Contact Dermatitis

Allergic Contact Dermatitis To Pd

Allergic Asthma

Atopic Asthma

Extrinsic Asthma

Extrinsic Asthma With Acute Exacerbation

Extrinsic Asthma With Status Asthmaticus

Asthma Allergic

Atopic Asthma, Susceptibility To

Ige-Mediated Allergic Asthma

Allergen-Induced Asthma

Allergic Asthma Without Stated Status Asthmaticus

Predominantly Allergic Asthma Without Stated Status Asthmaticus

Predominantly Allergic Asthma

Allergic Asthma Nos

Catarrh With Asthma

Allergic Bronchitis Nos

Extrinsic Allergic Asthma

Predominantly Allergic Asthma With Stated Status Asthmaticus

Churg-Strauss Syndrome

Eosinophilic Granulomatosis With Polyangiitis

Allergic Granulomatous Angiitis

Churg-Strauss Vasculitis

Allergic Angiitis

Egpa

Granulomatous Allergic Angiitis

Allergic Granulomatosis Angiitis

Allergic Angiitis And Granulomatosis

Allergic Granulomatosis

Allergic Granulomatous And Angiitis

Css

Pulmonary Eosinophilia

Asthmatic Pulmonary Eosinophilia

Eosinophilic Lung Infiltrate

Weingarten'S Syndrome

Hypereosinophilic Syndrome

Eosinophilia

HES

Eosinophilic Leukocytosis

Hypereosinophilic Syndrome, Idiopathic

Idiopathic Hypereosinophilic Syndrome

Disseminated Eosinophilic Collagen Disease

Eosinophilic Disorder

Disorders With Increased Eosinophil Counts

Bullous Pemphigoid

Benign Pemphigus

Senile Dermatitis Herpetiformis

Old Age Pemphigus

Parapemphigus

Pemphigoid

Pemphigoid Bullous

Pemphigoid, Bullous

Allergic Rhinitis

Hay Fever

Allergic Rhinitis, Susceptibility To

ALRH

Atopic Rhinitis

Seasonal Allergic Rhinitis

Non-Seasonal Allergic Rhinitis

Perenial Allergic Rhinitis

Pollenosis

Rhinitis Allergic Seasonal

Rhinitis, Allergic, Perennial

Allergic Rhinitis, Cause Unspecified

Pollinosis

Pollen Allergy

Allergy Nos Due To Pollen

Summer Catarrh

Other Seasonal Allergic Rhinitis

Anaplastic Large Cell Lymphoma

Alcl

Cd30 Positive Anaplastic Large Cell Lymphoma

Ki-1 Positive Anaplastic Large Cell Lymphoma

Primary Systemic Alcl

Sacl

Ki-1+ Anaplastic Large Cell Lymphoma

Primary Cutaneous T-Cell Non-Hodgkin Lymphoma

Cutaneous T-Cell Lymphoma

Cutaneous T Cell Lymphoma

Lymphoma, T-Cell, Cutaneous

Ctcl

Lymphoma T-Cell Cutaneous

Erythema Multiforme

Dermatostomatitis, Erythema Multiforme Type

Em

Erythema Multiforme Bullosum

Erythema Polymorphe, Erythema Multiforme Type

Febrile Mucocutaneous Syndrome

Herpes Iris, Erythema Multiforme Type

Stevens-Johnson Syndrome

Em - [Erythema Multiforme]

Allergic Disease

Hypersensitivity

Allergic Hypersensitivity Disease

Allergic Condition

Allergic Reaction

Allergic Disposition

Childhood-Onset Asthma

Childhood Asthma

Asthma Childhood

Echinococcosis

Hydatidosis

Echinococcal Disease

Echinococcosis Of Liver

Hepatic Echinococcosis

Hydatid Disease

Liver Echinococcus

Pulmonary Echinococcosis

Hydatids

Echinococcosis, Hepatic

Echinococcosis, Pulmonary

Unilocular Echinococcosis

Echinococcus Disease

Echinococcus Granulosus Infection

Echinococcus Multilocularis Infection

Dog Tapeworm Infection

Echinococcus Granulosus Infestation

Echinococciasis

Cystic Echinococcosis

Pulmonary Fibrosis

Fibrosis Of Lung

Aspergillosis

Aspergillosis, Susceptibility To

Infection Due To Aspergillus

Aspergilloma

Aspergillus Nodule

Simple Aspergilloma

Aspergillus

Aspergillus Flavus Infection

Aspergillus Fumigatus Infection

Aspergillus Infection

Infection By Aspergillus Fumigatus

Intracavitary Aspergillus Fungus Ball

Aspergillus Terreus

Skin Disease

Skin Diseases

Genodermatosis

Abnormality Of The Skin

Skin Diseases, Genetic

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders

Lymphoma, Hodgkin, Classic

Hodgkin Lymphoma

Hodgkin Disease

Hodgkin'S Lymphoma

Hodgkins Lymphoma

Classic Hodgkin Lymphoma

CHL

Hodgkin Lymphoma, Susceptibility To

Hl

Hodgkin'S Sarcoma

Stage I Subdiaphragmatic Hodgkin Lymphoma

Stage Ii Subdiaphragmatic Hodgkin Lymphoma

Lymphoma, Hodgkin'S

Classic Hodgkin Disease

Hodgkin'S Disease

Lymphoma, Hodgkin, Susceptibility To

Hodgkin'S Disease Of Intrapelvic Lymph Nodes

Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb

Malignant Lymphogranuloma

Malignant Lymphogranulomatosis

Malignant Hodgkin Lymphoma

Classical Hodgkin Lymphoma, Type Not Specified

Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus

Interstitial Lung Disease 2

Idiopathic Pulmonary Fibrosis

Ipf

Fibrocystic Pulmonary Dysplasia

Pulmonary Fibrosis, Idiopathic

Pulmonary Fibrosis, Idiopathic, Susceptibility To

Cryptogenic Fibrosing Alveolitis

ILD2

Idiopathic Pulmonary Fibrosis, Familial

Fibrosing Alveolitis, Cryptogenic

Uip

Fibrosing Alveolitis

Interstitial Pneumonitis, Usual

Familial Idiopathic Pulmonary Fibrosis

Idiopathic Fibrosing Alveolitis, Chronic Form

Usual Interstitial Pneumonia

Fibrosing Alveolitis Cryptogenic

Hamman-Rich Disease

Idiopathic Pulmonary Fibrosis Familial

Interstitial Pneumonitis Usual

Fibrosis Idiopathic Pulmonary

Fibrosis, Pulmonary, Idiopathic

Hamman-Rich Syndrome

Chronic Idiopathic Pulmonary Fibrosis

Acute Interstitial Pneumonia

Interstitial Pulmonary Fibrosis

Ipf - [Idiopathic Pulmonary Fibrosis]

Idiopathic Lung Fibrosis

Fibrosing Lung Disease

Pulmonary Fibrosis Nos

Fibrosing Pneumonitis

Mansonelliasis

Mansonellosis

Mansonella Perstans Infections

Mansonella Infestation

Contact Dermatitis

Contact Dermatitis/Eczema

Contact Eczema

Dermatitis Venenata

Dermatitis, Venenata

Dermatitis Contact

Dermatitis, Contact

Psoriasis
Disseminated Eosinophilic Collagen Disease
Pemphigus Vulgaris, Familial

Pemphigus Vulgaris

Familial Pemphigus Vulgaris

Pemphigus

Interstitial Lung Disease

Ild

Lung Diseases, Interstitial

Lung Diseases Interstitial

Interstitial Lung Diseases

Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis

Allergic Contact Dermatitis

Dermatitis, Allergic Contact

Contact Dermatitis, Allergic

Dermatitis Allergic Contact

Allergic Contact Eczema

Acd - [Allergic Contact Dermatitis]

Allergic Contact Dermatitis, Unspecified Cause

Allergic Dermatitis

Allergic Eczema

Allergy Dermatitis

Allergy Eczema

Allergic Contact Eczema Due To Clothing Or Footwear

Perfume Allergic Contact Dermatitis

Allergic Contact Dermatitis Due To Cosmetics

Allergic Contact Eczema Due To Cosmetics Or Fragrances

Allergic Contact Eczema Due To Dental Materials

Allergic Contact Eczema Due To Food Flavours Or Additives

Allergic Contact Eczema Due To Hairdressing Products

Allergic Contact Eczema Due To Metals Or Metal Salts

Allergic Contact Eczema Due To Proteins

Allergic Contact Eczema Due To Plastics Or Resin Systems

Allergic Contact Eczema Due To Preservatives Or Biocides

Allergic Contact Eczema Due To Rubber Chemicals

Rubber Dermatitis

Allergic Contact Eczema Due To Systemic Medicaments

Allergic Contact Eczema Due To Topical Medicaments

Allergic Contact Dermatitis Due To Drugs In Contact With Skin

Respiratory Allergy

Airway Allergy

Chronic Asthma
Neurodermatitis
Allergic Bronchopulmonary Aspergillosis

Aspergillosis, Allergic Bronchopulmonary

Abpa

Allergic Bronchopulmonary Mycosis

Hinson-Pepys Disease

Pulmonary Aspergillus Disease

Allergic Aspergillosis

Aspergillosis Allergic Bronchopulmonary

Abacavir Allergy

Abc Allergy

Irritant Dermatitis

Irritant Contact Dermatitis

Primary Irritant Dermatitis

Dermatitis, Irritant

Contact Dermatitis, Irritant

Irritant Contact Eczema

Icd - [Irritant Contact Dermatitis]

Irritant Contact Dermatitis, Unspecified Cause

Non-Allergic Contact Dermatitis

Irritant Contact Eczema Due To Wet Work

Irritant Contact Dermatitis Due To Detergents

Irritant Contact Eczema Due To Solvents

Irritant Contact Eczema Due To Exposure To Acids, Alkalis Or Other Chemical Irritants

Irritant Contact Eczema Due To Cosmetics Or Emollients

Irritant Contact Eczema Due To Topical Medicaments Or Antimicrobials

Irritant Contact Eczema Due To Plants Or Other Vegetable Matter

Irritant Contact Eczema Due To Foods

Irritant Contact Eczema Due To Friction, Sweating Or Contact With Body Fluids

Irritant Contact Eczema Due To Saliva

Irritant Contact Eczema Due To Incontinence

Incontinence-Associated Dermatitis

Refractory Plasma Cell Neoplasm
Nasal Cavity Disease

Disorder Of Nasal Cavity

Bronchial Disease

Bronchial Diseases

Bronchial Disorders

Bronchial Spasm

Nose Disease

Nose Diseases

Disorder Of The Nose

Nasal Disorder

Abnormality Of The Nose

Respiratory Failure

Acute Respiratory Failure

Chronic Respiratory Failure

Respiratory Insufficiency

Acute-On-Chronic Respiratory Failure

Respiratory Disease

Acute And Chronic Respiratory Failure

Respiratory Insufficiency/Failure

Chronic Respiratory Disease

Pulmonary Valve Insufficiency

Chronic Disease Of Respiratory System

Respiration Disorders

Respiratory Tract Diseases

Lung Failure Nos

Pulmonary Failure

Arf - [Acute Respiratory Failure]

Acute Respiratory Insufficiency

Acute Pulmonary Insufficiency

Acute Respiration Failure

Chronic Respiration Failure

Sezary'S Disease

Sezary Syndrome

Sézary Syndrome

Sezary'S Lymphoma

Sezary Disease

Sezary Erythroderma

Sezary Lymphoma

Integumentary System Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus CCL17 VGNC VGNC:60540
Bos taurus CCL17 VGNC VGNC:26945
Rattus norvegicus CCL17 RGD RGD:619924
Canis familiaris CCL17 VGNC VGNC:38882
Mus musculus CCL17 MGD MGI:1329039
Canis lupus familiaris CCL17 NCBI
Macaca mulatta CCL17 NCBI NCBI:574180
Others CCL17 NCBI