CCL20 - C-C motif chemokine ligand 20 Gene

中文名称：CC 基序趋化因子配体 20

种属: Homo sapiens

同用名: CKb4; LARC; ST38; MIP3A; Exodus; MIP-3a; SCYA20; MIP-3-alpha

基因 ID: 6364 | 基因类型: protein coding

关于 CCL20

Cytogenetic location: 2q36.3 Genomic coordinates (GRCh38): 2:227,813,842-227,817,556 (from NCBI)

This gene has 5 transcripts (splice variants), 86 orthologues and 25 paralogues. Biased expression in gall bladder (RPKM 83.4), urinary bladder (RPKM 31.6) and 7 other tissues.

功能概要

这种抗菌基因属于小细胞因子 CC 基因的亚家族。细胞因子是参与免疫调节和炎症过程的分泌蛋白家族。 CC 细胞因子是以两个相邻的半胱氨酸为特征的蛋白质。该基因编码的蛋白质对淋巴细胞具有趋化活性，可抑制骨髓祖细胞的增殖。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2014 年 9 月]

This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene displays chemotactic activity for lymphocytes and can repress proliferation of myeloid progenitors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

CCL20 基因产物(2)

mRNA	Protein	Name
NM_001130046.2	NP_001123518.1	C-C motif chemokine 20 isoform 2 precursor
NM_004591.3	NP_004582.1	C-C motif chemokine 20 isoform 1 precursor

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables CCR6 chemokine receptor binding	IDA IDA: 通过直接分析推断	12081481	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17703191	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: 通过直接分析推断	12949249	GOA
involved in calcium-mediated signaling	IDA IDA: 通过直接分析推断	25122636	GOA
involved in cell chemotaxis	IDA IDA: 通过直接分析推断	23765988	GOA
involved in chemotaxis	IDA IDA: 通过直接分析推断	20068036	GOA
involved in killing of cells of another organism	IDA IDA: 通过直接分析推断	12949249	GOA
acts upstream of or within positive regulation of T cell migration	IDA IDA: 通过直接分析推断	23620790	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CCL20 蛋白结构

IL8

0
96 a.a.

蛋白主名

其他名称

C-C motif chemokine 20

CC chemokine LARC

CCL20 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CCL20	P78556	PF4	Homo sapiens	P02776	SPR	28381538
种属内	CCL20	P78556	PF4	Homo sapiens	P02776	Filter Binding	28381538
种属内	CCL20	P78556	CCL5	Homo sapiens	P13501	Filter Binding	28381538
种属内	CCL20	P78556	CCL5	Homo sapiens	P13501	SPR	28381538
种属内	CCL20	P78556	CXCL12	Homo sapiens	P48061	Filter Binding	28381538
种属内	CCL20	P78556	CXCL12	Homo sapiens	P48061	SPR	28381538
种属内	CCL20	P78556	RALBP1	Homo sapiens	Q15311	Anti Tag CoIP	17703191

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CCL20 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7260	MIP-3 alpha/CCL20 Protein, Human (CHO)	P78556-1 (A27-M96)	≥95%
HY-P7262	MIP-3 alpha/CCL20 Protein, Human	P78556-1 (A27-M96)	≥95%
HY-P73814	MIP-3 alpha/CCL20 Protein, Human (His)	P78556-1 (A27-M96)	≥95%

关联疾病

疾病名称

别名

Sialadenitis

Sialoadenitis	Adenitis, Salivary Gland
Salivary Gland Inflammation	Salivary Gland Adenitis
Sialitis	Inflammation Of Salivary Gland
Inflammation Of Salivary Duct Or Gland	Salivary Glandular Adenitis
Sialoangiitis	Sialoangitis
Sialodochitis

Trichomoniasis

Trichomonas Infection	Trichomonas Infections
Disease Due To Trichomonadidae	Infection By Trichomonas
Trichomonadosis	Trichomonas Pruritus
Trichomonosis	Tricomoniasis

Psoriasis

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Colitis

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Periarthritis

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Autoimmune Disease Of Skin And Connective Tissue

Type 1 Diabetes Mellitus

Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus Type 1
IDDM	Type 1 Diabetes
Insulin-Dependent Diabetes Mellitus	T1D
Juvenile-Onset Diabetes	Jod
Diabetes Mellitus, Type 1	Diabetes Mellitus, Insulin-Dependent-1
Type I Diabetes Mellitus	Autoimmune Diabetes
Juvenile Diabetes	Juvenile-Onset Diabetes Mellitus
Diabetes, Insulin Dependent	Insulin-Dependent Diabetes Mellitus-1
Diabetes Mellitus Insulin-Dependent	Diabetes Autoimmune
Diabetes Mellitus, Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 1, Susceptibility To
Diabetes Type 1	Type I Diabetes
Diabetes, Autoimmune	T1dm - [Type 1 Diabetes Mellitus]
Iddm - [Insulin Dependent Diabetes Mellitus]	Type 1 Iddm
Juvenile Diabetes Mellitus Without Compications	Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications
Juvenile-Onset Diabetes Mellitus Without Compications	Ketosis-Prone Diabetes Mellitus Without Compications
Juvenile-Onset-Type Diabetes Mellitus Without Compications

Vaginal Disease

Vaginal Diseases

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Pulmonary Disease, Chronic Obstructive

Chronic Obstructive Pulmonary Disease	COPD
Pulmonary Disease, Chronic Obstructive, Severe Early-Onset	Chronic Obstructive Lung Disease
Chronic Obstructive Airway Disease	Pulmonary Disease, Chronic Obstructive, Susceptibility To
Cold	Severe Early-Onset Chronic Obstructive Pulmonary Disease
Pulmonary Disease Chronic Obstructive	Pulmonary Disease, Obstructive, Chronic, Susceptibility To
Chronic Obstructive Pulmonary Disease Of Horses	Common Cold
Upper Respiratory Infections	Copd - [Chronic Obstructive Pulmonary Disease]
Coad - [Chronic Obstructive Airways Disease]	Cold - [Chronic Obstructive Lung Disease]
Chronic Airway Disease Nos	Chronic Airways Limitation, Unspecified
Chronic Obstructed Airway, Unspecified	Chronic Obstructive Airway Disease, Unspecified
Chronic Obstructive Airway, Unspecified	Obstructive Lung Disease Nos
Chronic Obstructive Lung Disease Nos	Chronic Obstructive Lung Nos
Obstructive Pulmonary Disease Nos	Exacerbation Copd Nos
Acute Exacerbation Copd

Silo Filler'S Disease

Silo Filler Disease

Silo-Fillers' Disease

Psoriasis 11

PSORS11	Psoriasis Susceptibility 11
Psoriasis	Psoriasis Vulgaris
Psoriasis 11, Susceptibility To	Pv

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-151435	CCR6 antagonist 1	Antagonist	99.55%	否
HY-19548A	BEC hydrochloride	Inhibitor	≥98.0%	否
HY-162495	IDOR-1117-2520	Antagonist	/	否
HY-RS02090	CCL20 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	CCL20	VGNC	VGNC:38884
Rattus norvegicus	CCL20	RGD	RGD:3646
Mus musculus	CCL20	MGD	MGI:1329031
Macaca mulatta	CCL20	VGNC	VGNC:70699
Felis catus	CCL20	VGNC	VGNC:60542
Bos taurus	CCL20	VGNC	VGNC:26947
Others	CCL20	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CCL20 - C-C motif chemokine ligand 20 Gene

关于 CCL20

功能概要

CCL20 基因产物(2)

CCL20 蛋白结构

CCL20 蛋白互作信息

重组 CCL20 蛋白

关联疾病

直系同源

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CCL20 - C-C motif chemokine ligand 20 Gene

关于 CCL20

功能概要

CCL20 基因产物(2)

CCL20 蛋白结构

CCL20 蛋白互作信息

重组 CCL20 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z