2. Gene
  3. THADA - THADA armadillo repeat containing Gene

THADA - THADA armadillo repeat containing Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品

中文名称：含 THADA 犰狳重复

种属: Homo sapiens

同用名: GITA; ARMC13; Trm732

基因 ID: 63892 | 基因类型: protein coding

关于 THADA

Cytogenetic location: 2p21 Genomic coordinates (GRCh38): 2:43,230,851-43,596,038 (from NCBI)

This gene has 19 transcripts (splice variants) and 201 orthologues. Ubiquitous expression in lymph node (RPKM 6.5), thyroid (RPKM 6.2) and 25 other tissues.

功能概要

该基因是良性甲状腺腺瘤中 2p21 染色体畸变的靶标。该基因中的单核苷酸多态性 (SNP) 可能与 2 型糖尿病和多囊卵巢综合征有关。编码的蛋白质可能参与死亡受体途径和细胞凋亡。[RefSeq 提供，2016 年 9 月]

This gene is the target of 2p21 choromosomal aberrations in benign thyroid adenomas. Single nucleotide polymorphisms (SNPs) in this gene may be associated with type 2 diabetes and polycystic ovary syndrome. The encoded protein is likely involved in the death receptor pathway and Apoptosis. [provided by RefSeq, Sep 2016]

THADA 基因产物(7)

mRNA Protein Name
NM_001083953.2 NP_001077422.1 thyroid adenoma-associated protein isoform a
NM_001271643.2 NP_001258572.1 thyroid adenoma-associated protein isoform b
NM_001271644.2 NP_001258573.1 thyroid adenoma-associated protein isoform c
NM_001345923.2 NP_001332852.1 thyroid adenoma-associated protein isoform d
NM_001345924.2 NP_001332853.1 thyroid adenoma-associated protein isoform e
NM_001345925.2 NP_001332854.1 thyroid adenoma-associated protein isoform a
NM_022065.5 NP_071348.3 thyroid adenoma-associated protein isoform a
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables enzyme regulator activity IGI
IGI: 通过遗传相互作用推断
25404562 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of lipid homeostasis IGI
IGI: 通过遗传相互作用推断
28399403 GOA
involved in negative regulation of endoplasmic reticulum calcium ion concentration IMP
IMP: 通过突变表型推断
28399403 GOA
involved in tRNA methylation IGI
IGI: 通过遗传相互作用推断
25404562 GOA
involved in tRNA nucleoside ribose methylation IGI
IGI: 通过遗传相互作用推断
35559166 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

THADA 蛋白结构

DUF2428

DUF2428: Putative death-receptor fusion protein (DUF2428) (945 - 1248)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1800
  • 1953 a.a.
蛋白主名 其他名称

thyroid adenoma-associated protein

Trm732 homolog

THADA 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
THADA Q6YHU6 ATN1 Homo sapiens Q86V38
Validated Y2H
32814053
种属内
THADA Q6YHU6 ATN1 Homo sapiens Q86V38
Y2H Array
32814053
种属内
THADA Q6YHU6 ATN1 Homo sapiens Q86V38
Y2H Pooling
32814053
种属内
THADA Q6YHU6 USHBP1 Homo sapiens Q8N6Y0
Validated Y2H
25416956
种属内
THADA Q6YHU6 USHBP1 Homo sapiens Q8N6Y0
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Adenoma

Acinar Cell Adenoma

Adenomas

Acinic Cell Adenoma
Polycystic Ovary Syndrome

Polycystic Ovarian Syndrome

Pcos

Polycystic Ovarian Disease

Polycystic Ovaries

Stein-Leventhal Syndrome

Multicystic Ovaries

Polycystic Ovary

Sclerocystic Ovaries

Sclerocystic Ovary Syndrome

Stein-Leventhal Synd.

Cystic Disease Of Ovaries

Cystic Disease Of Ovary

Pco

Pcod

Sclerocystic Ovarian Degeneration

Polycystic Ovary Syndrome, Susceptibility To

Pcos - [Polycystic Ovary Syndrome]

Polycystic Ovary Nos

Pco - [Polycystic Ovary]
Hyperinsulinemic Hypoglycemia, Familial, 5

Hyperinsulinism Due To Insr Deficiency

HHF5

Familial Hyperinsulinemic Hypoglycemia 5

Hyperinsulinemic Hypoglycemia Due To Insr Deficiency

Hyperinsulinemic Hypoglycemia Due To Insulin Receptor Deficiency

Congenital Hyperinsulinism

Persistent Hyperinsulinemic Hypoglycemia Of Infancy

Phhi

Hyperinsulinemic Hypoglycemia Familial 5
Wolfram Syndrome 1

WFS1

Didmoad

Wfs

Diabetes Mellitus And Insipidus With Optic Atrophy And Deafness

Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness

Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Syndrome

Wolfram Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14468 THADA Human Pre-designed siRNA Set A Pre-designed Sets / 否
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z