2. Gene
  3. CHP2 - calcineurin like EF-hand protein 2 Gene

CHP2 - calcineurin like EF-hand protein 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：神经钙蛋白样 EF-手蛋白 2

种属: Homo sapiens

基因 ID: 63928 | 基因类型: protein coding

关于 CHP2

This gene has 1 transcript (splice variant), 114 orthologues and 8 paralogues. Biased expression in duodenum (RPKM 110.6), small intestine (RPKM 92.6) and 2 other tissues.

功能概要

该基因产物是一种小的钙结合蛋白，可通过控制质膜型 Na+/H+ 交换活性来调节细胞 pH 值。该蛋白与神经钙蛋白 B 具有序列相似性，可以结合并刺激神经钙蛋白 A (CnA) 的蛋白磷酸酶活性，并在神经钙蛋白/NFAT (活化 T 细胞核因子) 信号通路中发挥作用。 CHP 亚家族的另一个成员钙调神经磷酸酶 B 同源蛋白 1 位于 15 号染色体上，是钙调神经磷酸酶活性的抑制剂，具有与帕金森病相关的遗传表型 (OMIM:606988) 。该基因最初被鉴定为肿瘤相关抗原，之前被称为肝细胞癌相关抗原 520。[RefSeq 提供，2013 年 7 月]

This gene product is a small calcium-binding protein that regulates cell pH by controlling plasma membrane-type Na+/H+ exchange activity. This protein shares sequence similarity with Calcineurin B and can bind to and stimulate the protein Phosphatase activity of Calcineurin A (CnA) and functions in the Calcineurin/NFAT (nuclear factor of activated T cells) signaling pathway. Another member of the CHP subfamily, Calcineurin B homologous protein 1, is located on Chromosome 15 and is an inhibitor of Calcineurin activity and has a genetic phenotype associated with Parkinson's Disease (OMIM:606988). This gene was initially identified as a tumor-associated antigen and was previously referred to as Hepatocellular carcinoma-associated antigen 520. [provided by RefSeq, Jul 2013]

CHP2 基因产物(1)

mRNA Protein Name
NM_022097.4 NP_071380.1 calcineurin B homologous protein 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium ion binding IDA
IDA: 通过直接分析推断
21392185 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16710297 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to calcium ion IDA
IDA: 通过直接分析推断
18815128 GOA
involved in positive regulation of calcineurin-NFAT signaling cascade IDA
IDA: 通过直接分析推断
18815128 GOA
involved in positive regulation of cell population proliferation IDA
IDA: 通过直接分析推断
18815128 GOA
involved in positive regulation of phosphatase activity IDA
IDA: 通过直接分析推断
18815128 GOA
involved in positive regulation of protein import into nucleus IDA
IDA: 通过直接分析推断
18815128 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
18815128 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
21392185 GOA
located in nucleus IDA
IDA: 通过直接分析推断
21392185 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
21392185 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CHP2 蛋白结构

EF-hand_6

EF-hand_6: EF-hand domain (31 - 54)

EF-hand_7

EF-hand_7: EF-hand domain pair (115 - 138)

EF-hand_5

EF-hand_5: EF hand (160 - 178)

  • 0
  • 100
  • 196 a.a.
蛋白主名 其他名称

calcineurin B homologous protein 2

hepatocellular carcinoma antigen gene 520

CHP2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CHP2 O43745 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
种属内
CHP2 O43745 MDFI Homo sapiens Q99750
Validated Y2H
32296183
种属内
CHP2 O43745 MDFI Homo sapiens Q99750
Y2H Array
32296183
种属内
CHP2 O43745 SLC9A1 Homo sapiens P19634
ITC
31912575
种属内
CHP2 O43745 SLC9A1 Homo sapiens P19634
Anti Tag CoIP
33961781
种属内
CHP2 O43745 SLC9A1 Homo sapiens P19634
Fluorescence
31912575
种属内
CHP2 O43745 SLC9A1 Homo sapiens P19634
Biophysical
16710297
种属内
CHP2 O43745 SLC9A1 Homo sapiens P19634
MST
31912575
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Macs Syndrome

Macrocephaly, Alopecia, Cutis Laxa, And Scoliosis

Mycobacterium Avium Complex Disease

Rin2 Syndrome

Mycobacterium Avium-Intracellulare Infection

Tall Forehead, Sparse Hair, Skin Hyperextensibility, And Scoliosis

Mycobacterium Avium Complex

Mycobacterium Avium Infection

Infection Due To Mycobacterium Intracellulare

Mac Disease

Macrocephaly-Alopecia-Cutis Laxa-Scoliosis Syndrome

Rin2 Deficiency

Tall Forehead-Sparse Hair-Skin Hyperextensibility-Scoliosis Syndrome

MACS

Macrocephaly Alopecia Cutis Laxa And Scoliosis Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02653 CHP2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris CHP2 VGNC VGNC:54012
Mus musculus CHP2 MGD MGI:1917511
Macaca mulatta CHP2 VGNC VGNC:104688
Bos taurus CHP2 VGNC VGNC:27311
Rattus norvegicus CHP2 RGD RGD:727796
Felis catus CHP2 VGNC VGNC:107749
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