2. Gene
  3. ECSCR - endothelial cell surface expressed chemotaxis and apoptosis regulator Gene

ECSCR - endothelial cell surface expressed chemotaxis and apoptosis regulator Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：内皮细胞表面表达的趋化性和凋亡调节因子

种属: Homo sapiens

同用名: ARIA; ECSM2

基因 ID: 641700 | 基因类型: protein coding

关于 ECSCR

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:139,448,560-139,462,743 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele and 92 orthologues. Broad expression in placenta (RPKM 24.9), lung (RPKM 23.6) and 22 other tissues.

功能概要

由该基因编码的蛋白质主要存在于内皮细胞和血管中，参与细胞形状变化和 EGF 诱导的细胞迁移。它可以增强血管内皮生长因子受体-2/激酶插入域受体的活化，也可以促进内化激酶插入域受体的蛋白水解。该基因可能在血管生成相关疾病中发挥作用。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 6 月]

The protein encoded by this gene is primarily found in endothelial cells and blood vessels, where it is involved in cell shape changes and EGF-induced cell migration. It can enhance the activation of vascular endothelial growth factor receptor-2/kinase insert domain receptor and also promote the proteolysis of internalized kinase insert domain receptor. This gene may play a role in angiogenesis-related diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

ECSCR 基因产物(2)

mRNA Protein Name
NM_001077693.4 NP_001071161.1 endothelial cell-specific chemotaxis regulator isoform 1 precursor
NM_001293739.2 NP_001280668.1 endothelial cell-specific chemotaxis regulator isoform 2 precursor
蛋白主名 其他名称

endothelial cell-specific chemotaxis regulator

apoptosis regulator through modulating IAP expression

重组 ECSCR 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77919 ECSCR Protein, Human (HEK293, Fc) Q19T08 (Q25-A124) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04147 ECSCR Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ECSCR RGD RGD:1594804
Mus musculus ECSCR MGD MGI:1915795
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