MLST8 - MTOR associated protein, LST8 homolog Gene

中文名称：MTOR 相关蛋白，LST8 同系物

种属: Homo sapiens

同用名: GBL; LST8; POP3; WAT1; GbetaL

基因 ID: 64223 | 基因类型: protein coding

关于 MLST8

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:2,205,454-2,209,453 (from NCBI)

This gene has 35 transcripts (splice variants) and 203 orthologues. Ubiquitous expression in testis (RPKM 10.4), brain (RPKM 8.7) and 25 other tissues.

功能概要

启用蛋白质丝氨酸/苏氨酸激酶激活剂活性。参与 TORC1 信号； TOR 信号的正调控；和肌动蛋白细胞骨架组织的调节。 TORC1 复合体和 TORC2 复合体的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein serine/threonine kinase activator activity. Involved in TORC1 signaling; positive regulation of TOR signaling; and regulation of actin Cytoskeleton organization. Part of TORC1 complex and TORC2 complex. [provided by Alliance of Genome Resources, Apr 2022]

MLST8 基因产物(7)

mRNA	Protein	Name
NM_001199173.3	NP_001186102.1	target of rapamycin complex subunit LST8 isoform a
NM_001199174.3	NP_001186103.1	target of rapamycin complex subunit LST8 isoform a
NM_001199175.3	NP_001186104.1	target of rapamycin complex subunit LST8 isoform b
NM_001352057.2	NP_001338986.1	target of rapamycin complex subunit LST8 isoform c
NM_001352059.2	NP_001338988.1	target of rapamycin complex subunit LST8 isoform d
NM_001352060.2	NP_001338989.1	target of rapamycin complex subunit LST8 isoform d
NM_022372.6	NP_071767.3	target of rapamycin complex subunit LST8 isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	12408816	GOA
enables protein serine/threonine kinase activator activity	IDA IDA: 通过直接分析推断	12718876	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in TORC1 signaling	IMP IMP: 通过突变表型推断	12718876	GOA
involved in positive regulation of TOR signaling	IMP IMP: 通过突变表型推断	15467718	GOA
involved in regulation of actin cytoskeleton organization	IMP IMP: 通过突变表型推断	15467718	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of TORC1 complex	IDA IDA: 通过直接分析推断	12718876	GOA
part of TORC1 complex	IPI IPI: 通过物理相互作用推断	26678875	GOA
part of TORC2 complex	IDA IDA: 通过直接分析推断	24036451	GOA
part of TORC2 complex	IPI IPI: 通过物理相互作用推断	17461779	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MLST8 蛋白结构

WD40

0
100
200
300
326 a.a.

蛋白主名

其他名称

target of rapamycin complex subunit LST8

TORC subunit LST8

MLST8 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	MLST8	Q9BVC4	RPTOR	Homo sapiens	Q8N122	Anti Tag CoIP	20562859
种属内	MLST8	Q9BVC4	RPTOR	Homo sapiens	Q8N122	Anti Tag CoIP	12408816
种属内	MLST8	Q9BVC4	MTOR	Homo sapiens	P42345	Anti Tag CoIP	12408816
种属内	MLST8	Q9BVC4	MTOR	Homo sapiens	P42345	Anti Tag CoIP	20562859
种属内	MLST8	Q9BVC4	MTOR	Homo sapiens	P42345	Anti Tag CoIP	33961781

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Subependymal Glioma

Mixed Subependymoma-Ependymoma	Subependymal Astrocytoma
Who Grade I Ependymal Tumor	Glioma, Subependymal

Kidney Angiomyolipoma

Angiomyolipoma Of Kidney

Renal Angiomyolipoma

Dravet Syndrome

Severe Myoclonic Epilepsy Of Infancy	Severe Myoclonic Epilepsy In Infancy
Smei	Epileptic Encephalopathy, Early Infantile, 6
DRVT	Developmental And Epileptic Encephalopathy 6a
Dee6a	Eiee6
Developmental And Epileptic Encephalopathy, 6	Dee6
Developmental And Epileptic Encephalopathy 6	Early Infantile Epileptic Encephalopathy 6
Myoclonic Epilepsy, Severe, Of Infancy	Sme
Severe Myoclonus Epilepsy Of Infancy	Borderline Smei
Smeb	Smeb-M
Smeb-O	Smeb-Sw
Smei-Borderland	Smei-Borderland More Than One Feature
Smei-Borderland-Myoclonic Seizures	Smei-Borderland-Spike Wave
Intractable Childhood Epilepsy With Generalized Tonic-Clonic Seizures	ICEGTC
Infantile Severe Myoclonic Epilepsy	Epilepsy, Intractable Childhood, With Generalized Tonic-Clonic Seizures

Subependymal Giant Cell Astrocytoma

Sega	Astrocytoma Subependymal Giant Cell
Subependymal Giant-Cell Astrocytoma

Benign Ependymoma

Ependymoma	Epithelial Ependymoma
Who Grade Ii Ependymal Tumor	Myxopapillary Ependymoma

Cowden Syndrome 1

Bannayan-Riley-Ruvalcaba Syndrome	Pten Hamartoma Tumor Syndrome
Lhermitte-Duclos Disease	Bannayan-Zonana Syndrome
Phts	Riley-Smith Syndrome
Bzs	Ruvalcaba-Myhre-Smith Syndrome
Multiple Hamartoma Syndrome	Rmss
Brrs	Dysplastic Gangliocytoma Of The Cerebellum
CWS1	Cs
Cd	Mham
Pten Hamartoma Tumor Syndrome With Granular Cell Tumor	Macrocephaly Multiple Lipomas And Hemangiomata
Bannayan-Ruvalcaba-Riley Syndrome	Myhre-Riley-Smith Syndrome
LDD	Cerebelloparenchymal Disorder Vi
Hamartoma Syndrome, Multiple	Bbrs
Macrocephaly, Pseudopapilledema, And Multiple Hemangiomata	Macrocephaly, Multiple Lipomas, And Hemangiomata
Macrocephaly Pseudopapilledema And Multiple Hemangiomas	Ruvalcaba -Myhre-Smith Syndrome
Ruvalcaba-Myhre Syndrome	Cowden Disease
Macrocephaly Pseudopapilledema And Multiple Hemangiomata	Cerebellar Granule Cell Hypertrophy And Megalencephaly
Cpd6	Pten Hamartoma Tumor Syndromes
Cowden Syndrome, Type 1

Withdrawal Disorder

Withdrawal Syndrome

Substance Withdrawal Syndrome

Fragile X Syndrome

FXS	Martin-Bell Syndrome
Fraxa Syndrome	Marker X Syndrome
X-Linked Mental Retardation And Macroorchidism	Fragile X Mental Retardation Syndrome
Fra Syndrome	Mental Retardation, X-Linked, Associated With Marxq28
X-Linked Intellectual Disability And Macroorchidism	Frax Syndrome
Symptomatic Form Of Fragile X Syndrome In Female Carriers	Fragile-X Syndrome
Fraxe Syndrome

Neurodegeneration With Brain Iron Accumulation

Nbia	Neurodegeneration With Brain Iron Accumulation Disorders
Neurodegeneration, With Brain Iron Accumulation

Cowden Syndrome

Cowden Disease	Multiple Hamartoma Syndrome
Cowden'S Disease	Lhermitte-Duclos Disease
Cd	Cs
Mham	Dysplastic Gangliocytoma Of Cerebellum
Cowden'S Syndrome	Hamartoma Syndrome, Multiple

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS08502	MLST8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	MLST8	VGNC	VGNC:74820
Mus musculus	MLST8	MGD	MGI:1929514
Rattus norvegicus	MLST8	RGD	RGD:69242
Felis catus	MLST8	VGNC	VGNC:63527
Bos taurus	MLST8	VGNC	VGNC:31507
Canis familiaris	MLST8	VGNC	VGNC:43266
Others	MLST8	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

MLST8 - MTOR associated protein, LST8 homolog Gene

关于 MLST8

功能概要

MLST8 基因产物(7)

MLST8 蛋白结构

MLST8 蛋白互作信息

关联疾病

直系同源

热门区域

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MLST8 - MTOR associated protein, LST8 homolog Gene

关于 MLST8

功能概要

MLST8 基因产物(7)

MLST8 蛋白结构

MLST8 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z