2. Gene
  3. SCX - scleraxis bHLH transcription factor Gene

SCX - scleraxis bHLH transcription factor Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：硬化性 bHLH 转录因子

种属: Homo sapiens

同用名: SCXA; SCXB; bHLHa48

基因 ID: 642658 | 基因类型: protein coding

关于 SCX

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:144,266,453-144,268,481 (from NCBI)

This gene has 1 transcript (splice variant), 222 orthologues and 13 paralogues. Ubiquitous expression in appendix (RPKM 1.6), prostate (RPKM 1.6) and 25 other tissues.

功能概要

启用 DNA 结合转录激活因子活性、RNA 聚合酶 II 特异性和 bHLH 转录因子结合活性。有助于电子箱绑定活动。参与 RNA 聚合酶 II 对转录的正调控。位于核内。转录调节复合物的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and bHLH transcription factor binding activity. Contributes to E-box binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. [provided by Alliance of Genome Resources, Apr 2022]

SCX 基因产物(1)

mRNA Protein Name
NM_001080514.3 NP_001073983.1 basic helix-loop-helix transcription factor scleraxis
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
10775504 GOA
contributes to E-box binding IDA
IDA: 通过直接分析推断
10775504 GOA
enables bHLH transcription factor binding IPI
IPI: 通过物理相互作用推断
10775504 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
10775504 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
10775504 GOA
part of transcription regulator complex IDA
IDA: 通过直接分析推断
10775504 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

basic helix-loop-helix transcription factor scleraxis

class A basic helix-loop-helix protein 41

SCX 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SCX Q7RTU7 TCF4 Homo sapiens P15884-3
Y2H Array
32296183
Intra SCX Q7RTU7 TCF4 Homo sapiens P15884-3
Y2H Prey Pooling
32296183
Intra SCX Q7RTU7 MYF5 Homo sapiens P13349
Y2H Prey Pooling
32296183
Intra SCX Q7RTU7 MYF5 Homo sapiens P13349
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Calcific Tendinitis

Calcific Tendinitis Nos
Anomalous Left Coronary Artery From The Pulmonary Artery

Bland White Garland Syndrome

Alcapa

Bland-White-Garland Syndrome

White-Garland Syndrome
Acromesomelic Dysplasia 2a

Chondrodysplasia, Grebe Type

Acromesomelic Dysplasia, Grebe Type

Grebe Chondrodysplasia

Amdg

Grebe Syndrome

AMD2A

Grebe Dysplasia

Achondrogenesis, Brazilian

Achondrogenesis, Type Ii, Formerly

Acromesomelic Dysplasia-2a

Achondrogenesis Type Ii

Brazilian Achondrogenesis

Acromesomelic Chondrodysplasia, Grebe Type
Tendinitis

Tendinopathy
Cleft Soft Palate

Cleft Velum

Cleft Velum Palatinum

Soft Cleft Palate

Soft Palate Perforation
Fibrodysplasia Ossificans Progressiva

Myositis Ossificans Progressiva

Progressive Myositis Ossificans

FOP

Progressive Ossifying Myositis

Myositis Ossificans

Stone Man Syndrome

Man Of Stone

Myositis Ossificans Progressive

Diffuse Progressive Ossifying Polymyositis

Fibrodysplasia Ossificans Congenita

Myositis Ossificans Progressiva, Site Unspecified

Münchmeyer Disease

Fop - [Fibrodysplasia Ossificans Progressiva]

Progressive Myositis Ossificans Calcification
Lacrimoauriculodentodigital Syndrome

Ladd Syndrome

Levy-Hollister Syndrome

Lacrimo-Auriculo-Dento-Digital Syndrome

LADD

Lacrimoauriculodento-Digital Syndrome

Levy Hollister Syndrome

Lard Syndrome

Lacrimoauriculoradiodental Syndrome

LADDS

Congenital Duodenal Obstruction Due To Malrotation Of Intestine
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12574 SCX Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SCX RGD RGD:1588254
Bos taurus SCX VGNC VGNC:58408
Mus musculus SCX MGD MGI:102934
Macaca mulatta SCX VGNC VGNC:84112
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