2. Gene
  3. PGA4 - pepsinogen A4 Gene

PGA4 - pepsinogen A4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：胃蛋白酶原 A4

种属: Homo sapiens

基因 ID: 643847 | 基因类型: protein coding

关于 PGA4

Cytogenetic location: 11q12.2 Genomic coordinates (GRCh38): 11:61,222,347-61,231,694 (from NCBI)

This gene has 8 transcripts (splice variants), 165 orthologues and 9 paralogues. Restricted expression toward stomach (RPKM 23688.7).

功能概要

该基因编码消化酶胃蛋白酶的蛋白质前体，胃蛋白酶是内肽酶肽酶 A1 家族的成员。编码的前体由胃主细胞分泌，并在酸性条件下进行自催化裂解，形成活性酶，在消化膳食蛋白质中发挥作用。该基因存在于 11 号染色体上的一组相关基因中，每个基因编码多种胃蛋白酶原中的一种。血清中的胃蛋白酶原水平可作为萎缩性胃炎和胃癌的生物标志物。[RefSeq 提供，2015 年 7 月]

This gene encodes a protein precursor of the digestive Enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active Enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric Cancer. [provided by RefSeq, Jul 2015]

PGA4 基因产物(1)

mRNA Protein Name
NM_001079808.6 NP_001073276.1 pepsin A-4 preproprotein
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PGA4 蛋白结构

A1_Propeptide

A1_Propeptide: A1 Propeptide (17 - 45)

Asp

Asp: Eukaryotic aspartyl protease (75 - 386)

  • 0
  • 100
  • 200
  • 300
  • 388 a.a.
蛋白主名 其他名称

pepsin A-4

pepsinogen 4, group I (pepsinogen A)

PGA4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PGA4 P0DJD7 SPAG4 Homo sapiens Q9NPE6
Validated Y2H
32296183
种属内
PGA4 P0DJD7 SPAG4 Homo sapiens Q9NPE6
Y2H Array
32296183
种属内
PGA4 P0DJD7 STOM Homo sapiens P27105
Y2H Prey Pooling
32296183
种属内
PGA4 P0DJD7 STOM Homo sapiens P27105
Validated Y2H
32296183
种属内
PGA4 P0DJD7 STOM Homo sapiens P27105
Y2H Array
32296183
种属内
PGA4 P0DJD7 FNDC9 Homo sapiens Q8TBE3
Y2H Prey Pooling
32296183
种属内
PGA4 P0DJD7 FNDC9 Homo sapiens Q8TBE3
Validated Y2H
32296183
种属内
PGA4 P0DJD7 FNDC9 Homo sapiens Q8TBE3
Y2H Array
32296183
种属内
PGA4 P0DJD7 CD74 Homo sapiens P04233-2
Y2H Prey Pooling
32296183
种属内
PGA4 P0DJD7 CD74 Homo sapiens P04233-2
Y2H Array
32296183
种属内
PGA4 P0DJD7 FIMP Homo sapiens Q96LL3
Validated Y2H
32296183
种属内
PGA4 P0DJD7 FIMP Homo sapiens Q96LL3
Y2H Array
32296183
种属内
PGA4 P0DJD7 FIMP Homo sapiens Q96LL3
Y2H Prey Pooling
32296183
种属内
PGA4 P0DJD7 AMIGO1 Homo sapiens Q86WK6
Validated Y2H
32296183
种属内
PGA4 P0DJD7 AMIGO1 Homo sapiens Q86WK6
Y2H Prey Pooling
32296183
种属内
PGA4 P0DJD7 AMIGO1 Homo sapiens Q86WK6
Y2H Array
32296183
种属内
PGA4 P0DJD7 TMEM106C Homo sapiens Q9BVX2
Y2H Prey Pooling
32296183
种属内
PGA4 P0DJD7 TMEM106C Homo sapiens Q9BVX2
Validated Y2H
32296183
种属内
PGA4 P0DJD7 TMEM106C Homo sapiens Q9BVX2
Y2H Array
32296183
种属内
PGA4 P0DJD7 HHLA2 Homo sapiens Q9UM44
Y2H Prey Pooling
32296183
种属内
PGA4 P0DJD7 HHLA2 Homo sapiens Q9UM44
Validated Y2H
32296183
种属内
PGA4 P0DJD7 HHLA2 Homo sapiens Q9UM44
Y2H Array
32296183
种属内
PGA4 P0DJD7 PVR Homo sapiens P15151
Y2H Prey Pooling
32296183
种属内
PGA4 P0DJD7 PVR Homo sapiens P15151
Validated Y2H
32296183
种属内
PGA4 P0DJD7 PVR Homo sapiens P15151
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PGA4 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77135 Pepsinogen A4/PGA4 Protein, Human (HEK293, Fc) P0DJD7/NP_001073276.1 (I16-A388) ≥95%
HY-P77136 Pepsinogen A4/PGA4 Protein, Human (HEK293, His) P0DJD7 (I16-A388) ≥95%

关联疾病

疾病名称 别名
Atrophic Gastritis

Gastritis, Atrophic

Gastric Atrophy

Gastritis Atrophic
Gastritis

Acute Gastric Mucosal Erosion

Erosive Gastritis

Erosive Gastropathy

Gastritis Erosive

Idiopathic Erosive/Hemorrhagic Gastritis

Inflammation Of Gastric Mucosa

Gastroduodenitis

Gastritis Nos

Noninfectious Gastroenteritis

Nonbacterial Gastroenteritis Of Infant

Acute Gastric Infection

Acute Simple Gastritis

Chronic Antral Gastritis

Chronic Fundal Gastritis

Chronic Simple Gastritis

Acute Gastroduodenitis

Acute Antral Gastritis

Acute Erosive Gastritis

Bile Reflux Gastritis

Gastritis Due To Biliary Reflux
Chief Cell Adenoma

Chief Cell Adenoma Of Parathyroid Gland
Macular Degeneration, Age-Related, 10

ARMD10

Age Related Macular Degeneration 10

Macular Degeneration, Age-Related, Type 10
Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10372 PGA4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus PGA4 MGD MGI:1915935
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