2. Gene
  3. MMP25 - matrix metallopeptidase 25 Gene

MMP25 - matrix metallopeptidase 25 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：基质金属肽酶 25

种属: Homo sapiens

同用名: MMP20; MMPL1; MMP-25; MMP20A; MT6MMP; MTMMP6; MT-MMP6; MT6-MMP; MT-MMP 6

基因 ID: 64386 | 基因类型: protein coding

关于 MMP25

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:3,046,561-3,060,726 (from NCBI)

This gene has 4 transcripts (splice variants), 174 orthologues and 23 paralogues. Biased expression in bone marrow (RPKM 12.9), appendix (RPKM 8.4) and 7 other tissues.

功能概要

基质金属蛋白酶 (MMP) 家族的蛋白质参与正常生理过程 (如胚胎发育、繁殖和组织重塑) 以及疾病过程 (如关节炎和转移) 中细胞外基质的分解。大多数 MMP 被分泌为无活性的前蛋白，当被细胞外蛋白酶切割时被激活。然而，由该基因编码的蛋白质是膜型 MMP (MT-MMP) 亚家族的成员，通过糖基磷脂酰肌醇锚附着在质膜上。为了应对细菌感染或炎症，编码的蛋白质被认为会使 α-1 蛋白酶抑制剂失活，α-1 蛋白酶抑制剂是一种主要的组织保护剂，可防止活化的嗜中性粒细胞释放蛋白水解酶，从而促进嗜中性粒细胞跨内皮迁移至炎症部位。编码的蛋白质还可能通过激活 MMP2 在肿瘤侵袭和转移中发挥作用。该基因以前被称为 MMP20，但已更名为 MMP25。[RefSeq 提供，2008 年 7 月]

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to Bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic Enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. [provided by RefSeq, Jul 2008]

MMP25 基因产物(1)

mRNA Protein Name
NM_022468.5 NP_071913.1 matrix metalloproteinase-25 preproprotein
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MMP25 蛋白结构

PG_binding_1

PG_binding_1: Putative peptidoglycan binding domain (26 - 85)

Peptidase_M10

Peptidase_M10: Matrixin (115 - 280)

Hemopexin

Hemopexin: Hemopexin (321 - 364)

Hemopexin

Hemopexin: Hemopexin (370 - 412)

Hemopexin

Hemopexin: Hemopexin (416 - 457)

Hemopexin

Hemopexin: Hemopexin (465 - 492)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 562 a.a.
蛋白主名 其他名称

matrix metalloproteinase-25

leukolysin

关联疾病

疾病名称 别名
Amelogenesis Imperfecta, Type Iiia

Ai3

Adhcai

Amelogenesis Imperfecta Type 3

AI3A

Amelogenesis Imperfecta, Type Iii

Amelogenesis Imperfecta, Hypocalcification Type, Autosomal Dominant

Amelogenesis Imperfecta Type 3a

Amelogenesis Imperfecta Hypomineralization Type

Amelogenesis Imperfecta Type Iii

Hypocalcified Amelogenesis Imperfecta

Amelogenesis Imperfecta, Type 3

Amelogenesis Imperfecta, Hypomineralization Type

Autosomal Dominant Amelogenesis Imperfecta Hypocalcification Type

Amelogenesis Imperfecta 3a

Amelogenesis Imperfecta Hypocalcification Type Autosomal Dominant
Dental Fluorosis

Mottled Teeth

Intrinsic Enamel Discolouration Of Fluorosis

Mottling Of Enamel

Fluorosis, Dental

Dental Fluorosis, Acquired
Jalili Syndrome

Cone-Rod Dystrophy And Amelogenesis Imperfecta

Cone Rod Dystrophy-Amelogenesis Imperfecta Syndrome

Cone-Rod Dystrophy Amelogenesis Imperfecta

Cone-Rod Dystrophy With Amelogenesis Imperfecta

JALIS

Cone Rod Dystrophy Amelogenesis Imperfecta
Dentin Caries

Compound Dental Caries

Dental Caries Extending Into Dentine

Dental Caries Extending Into Dentin
Teeth Hard Tissue Disease
Amelogenesis Imperfecta

Ai

Congenital Enamel Hypoplasia

Al - [Amelogenesis Imperfecta]
Junctional Epidermolysis Bullosa

Epidermolysis Bullosa, Junctional

Jeb

Epidermolysis Bullosa Atrophicans

Congenital Junctional Epidermolysis Bullosa

Epidermolysis Bullosa Junctional

Junctional Eb - [Epidermolysis Bullosa]

Jeb - [Junctional Epidermolysis Bullosa]

Lucidolytic Epidermolysis Bullosa
Tooth Agenesis

Oligodontia

Hypodontia

Selective Tooth Agenesis

Tooth Agenesis, Selective

Familial Tooth Agenesis

Anodontia

Congenital Absence Of One Tooth
Cone-Rod Dystrophy 2

Cone-Rod Dystrophy

CORD2

Cone-Rod Retinal Dystrophy

Rcrd2

Cone-Rod Retinal Dystrophy 2

Crd2

Cord

Crd

Retinal Cone-Rod Dystrophy

Cone-Rod Retinal Dystrophy-2

Retinal Cone-Rod Dystrophy 2

Tapetoretinal Degeneration

Cone-Rod Degeneration

Cone Rod Dystrophy

Dystrophy, Cone-Rod

Dystrophy, Cone-Rod, Type 2

Retinitis Pigmentosa

Retinitis Pigmentosa 2

Progressive Cone-Rod Dystrophy
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08544 MMP25 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris MMP25 VGNC VGNC:43284
Rattus norvegicus MMP25 RGD RGD:1308298
Macaca mulatta MMP25 VGNC VGNC:74747
Bos taurus MMP25 VGNC VGNC:31527
Mus musculus MMP25 MGD MGI:2443938
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