2. Gene
  3. ARAP3 - ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 Gene

ARAP3 - ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：具有 RhoGAP 结构域、锚蛋白重复序列和 PH 结构域 3 的 ArfGAP

种属: Homo sapiens

同用名: DRAG1; CENTD3

基因 ID: 64411 | 基因类型: protein coding

关于 ARAP3

Cytogenetic location: 5q31.3 Genomic coordinates (GRCh38): 5:141,653,402-141,682,230 (from NCBI)

This gene has 7 transcripts (splice variants), 197 orthologues and 28 paralogues. Broad expression in lung (RPKM 9.2), fat (RPKM 7.9) and 24 other tissues.

功能概要

该基因编码含有 ARF-GAP、RHO-GAP、RAS 相关和 pleckstrin 同源结构域的磷酸肌醇结合蛋白。 ARF-GAP 和 RHO-GAP 结构域协同调节细胞骨架和细胞形状的重排。它是一种特定的 PtdIns (3,4,5) P3/PtdIns (3,4) P2 刺激的 Arf6-GAP 蛋白。已发现该基因的可变剪接转录本，但其生物学有效性尚未确定。[RefSeq 提供，2015 年 9 月]

This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell Cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively spliced transcript has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Sep 2015]

ARAP3 基因产物(1)

mRNA Protein Name
NM_022481.6 NP_071926.4 arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
IDA: 通过直接分析推断
11804589 GOA
enables phosphatidylinositol-3,4-bisphosphate binding IDA
IDA: 通过直接分析推断
11804589 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15090612 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ARAP3 蛋白结构

SAM_2

SAM_2: SAM domain (Sterile alpha motif) (8 - 60)

PH

PH: PH domain (290 - 379)

ArfGap

ArfGap: Putative GTPase activating protein for Arf (491 - 605)

RhoGAP

RhoGAP: RhoGAP domain (920 - 1067)

RA

RA: Ras association (RalGDS/AF-6) domain (1120 - 1207)

PH

PH: PH domain (1241 - 1324)

  • 0
  • 300
  • 600
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  • 1200
  • 1544 a.a.
蛋白主名 其他名称

arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

ARF-GAP, RHO-GAP, ankyrin repeat and plekstrin homology domains-containing protein 3

ARAP3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ARAP3 Q8WWN8 SH3KBP1 Homo sapiens Q96B97
Anti Tag CoIP
15090612
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Oropharyngeal Anthrax
Hyaline Fibromatosis Syndrome

Juvenile Hyaline Fibromatosis

Inherited Systemic Hyalinosis

Puretic Syndrome

Infantile Systemic Hyalinosis

HFS

Hyalinosis, Systemic

Systemic Hyalinosis

Molluscum Fibrosum

Murray Syndrome

Murray-Puretic-Drescher Syndrome

Ish

Jhf

Fibromatosis, Juvenile Hyaline

Hyalinosis, Systemic Infantile

Fibromatosis, Hyaline Syndrome

Neurofibromatosis 1
Gastrointestinal Anthrax
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00889 ARAP3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus ARAP3 MGD MGI:2147274
Macaca mulatta ARAP3 VGNC VGNC:69893
Canis familiaris ARAP3 VGNC VGNC:38027
Rattus norvegicus ARAP3 RGD RGD:1304938
Felis catus ARAP3 VGNC VGNC:59864
Bos taurus ARAP3 VGNC VGNC:58361
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