SPANXD - SPANX family member D Gene

中文名称：SPANX 家族成员 D

种属: Homo sapiens

同用名: CT11.3; CT11.4; SPANXC; SPANXE; SPANX-C; SPANX-D; SPANX-E; dJ171K16.1

关于 SPANXD

功能概要

几个睾丸特异性基因的时间调节转录和翻译需要在雄性生殖细胞谱系中启动成熟精子形成所必需的一系列分子和形态学变化。该基因是癌症/睾丸相关基因 SPANX 家族的成员，位于 X 染色体上的一个簇中。SPANX 基因编码差异表达的睾丸特异性蛋白质，这些蛋白质定位于各种亚细胞区室。这个特殊的基因编码一种与细胞核相关的精子蛋白，但尽管有人提出它在精子发生中的作用，但这个家族成员的具体功能尚未确定。该基因的多态性可能与前列腺癌易感性有关。[RefSeq 提供，2014 年 4 月]

Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of Cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene encodes a sperm protein that is associated with the nucleus but, although a role in spermatogenesis is suggested, the specific function of this family member has not yet been determined. Polymorphisms in this gene may be associated with prostate Cancer susceptibility. [provided by RefSeq, Apr 2014]