GORASP1 - golgi reassembly stacking protein 1 Gene

中文名称：高尔基重组堆积蛋白 1

种属: Homo sapiens

同用名: P65; GOLPH5; GRASP65

关于 GORASP1

功能概要

高尔基复合体在内质网输出的蛋白质的分类和修饰中起着关键作用。该基因编码的蛋白质是一种参与建立高尔基体堆叠结构的膜蛋白。它是一种 Caspase-3 底物，这种编码蛋白的切割有助于细胞凋亡中的高尔基体断裂。这种编码的蛋白质可以与高尔基基质蛋白 GOLGA2 形成复合物，并且这种复合物与囊泡对接蛋白 p115 结合。可变剪接导致该基因的多个转录变体。[RefSeq 提供，2013 年 7 月]

The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a membrane protein involved in establishing the stacked structure of the Golgi apparatus. It is a Caspase-3 substrate, and cleavage of this encoded protein contributes to Golgi fragmentation in Apoptosis. This encoded protein can form a complex with the Golgi matrix protein GOLGA2, and this complex binds to the vesicle docking protein p115. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]